Isomaltose (6-O-α-D-Glucopyranosyl-D-glucose) is a disaccharide similar to maltose, with an α-(1-6) linkage, while maltose has an α-(1-4) linkage[1]. Isomaltose is a metabolite produced by Escherichia coli (strains K12, MG1655)[2]. Isomaltose can be used as a substitute for sucrose and is suitable for people with diabetes and those with a predisposition to diabetes[3]. Adding Isomaltose to cattle feed can serve as an effective and rapid energy source, helping to maintain milk productivity and animal health[4].
References:
[1] Lee B H, Rose D R, Lin A H M, et al. Contribution of the individual small intestinal α-glucosidases to digestion of unusual α-linked glycemic disaccharides[J]. Journal of Agricultural and Food Chemistry, 2016, 64(33): 6487-6494.
[2] Zhang F, Wang W, Bah F B M, et al. Heterologous expression of a thermostable α-glucosidase from Geobacillus sp. strain HTA-462 by Escherichia coli and its potential application for isomaltose–oligosaccharide synthesis[J]. Molecules, 2019, 24(7): 1413.
[3] Chen Z, Gu F, Wu J. Impact of Isomaltulose on Glycemic Response in Diabetic and Healthy Populations: A Meta-Analysis[J]. Nutrients, 2025, 17(11): 1940.
[4] Butkalyuk Y M, Zhelavskyi M M. Isomaltose in cattle feeding: biochemical processes and prevention of metabolic changes[J]. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 2024, 26(116): 123-129.
Isomaltose (6-O-α-D-Glucopyranosyl-D-glucose)是一种与麦芽糖相似的二糖，其连接方式为α-(1-6)连接，而麦芽糖的连接方式为α-(1-4)连接[1]。Isomaltose是一种由大肠杆菌（菌株K12、MG1655）产生的代谢物[2]。Isomaltose能够作为蔗糖的替代物，适合于糖尿病患者及有糖尿病倾向的人群[3]。Isomaltose添加到牛饲料中能够作为一种有效的快速能量来源，有助于维持牛奶生产力和动物健康[4]。