Indole-3-carboxylic acid is a plant metabolite derived from tryptophan that has been found in Arabidopsis and has diverse biological activities.1,2,3,4 It induces resistance in Arabidopsis against the plant necrotrophic fungus P. cucumerina when applied as a soil-drenching solution at a concentration of 150 ?M prior to infection.2 Indole-3-carboxylic acid is cytotoxic to A549 human lung and MCF-7 human breast cancer cells (EC50s = 4.6 and 12.9 ?g/ml, respectively) and inhibits HIV replication in infected H9 lymphocytes (IC50 = 16.4 ?g/ml).3 Indole-3-carboxylic acid has also been used as a precursor in the synthesis of substituted thiadiazoles with anticancer activity.4
1.Iven, T., K?nig, S., Singh, S., et al.Transcriptional activation and production of tryptophan-derived secondary metabolites in Arabidopsis roots contributes to the defense against the fungal vascular pathogen Verticillium longisporumMol. Plant5(6)1389-1402(2012) 2.Gamir, J., Pastor, V., Sánchez-Bel, P., et al.Starch degradation, abscisic acid and vesicular trafficking are important elements in callose priming by indole-3-carboxylic acid in response to Plectosphaerella cucumerina infectionPlant J.96(3)518-531(2018) 3.Wu, P.-L., Lin, F.-W., Wu, T.-S., et al.Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensisChem. Pharm. Bull. (Tokyo)52(3)345-349(2004) 4.Kumar, D., Kumar, N.M., Chang, K.-A., et al.Synthesis and anticancer activity of 5-(3-indolyl)-1,3,4-thiadiazolesEur. J. Med. Chem.45(10)4664-4668(2010)