Peptide YY (PYY), human is a peptide hormone secreted by intestinal L cells [1]. Peptide YY binds to Y2 receptors on the hypothalamus and vagus nerve, inhibiting the release of neuropeptide Y, thereby reducing appetite, delaying gastric emptying, and decreasing intestinal motility [2-3]. Peptide YY is primarily used in the research of diseases such as obesity, diabetes, and metabolic syndrome [4].
In diet-induced obesity mice model, Continuous administration of Peptide YY (1mg/kg; sc; 7d) can significantly inhibit food intake and induce weight loss, with an average weight loss of approximately 8.3%, showing a stable and sustainable anorectic effect [5]. In C57BLKS/J db/db mice, the combined use of Peptide YY (1mg/kg; sc; 14d) and GLP-1 can significantly increase the glucose infusion rate, enhance the systemic glucose disposal rate, and inhibit hepatic glucose production, thereby improving insulin sensitivity [6].
References:
[1]. Batterham R L, Bloom S R. The gut hormone peptide YY regulates appetite[J]. Annals of the New York Academy of Sciences, 2003, 994(1): 162-168.
[2]. Peptide YY binds to Y2 receptors on the hypothalamus and vagus nerve, inhibiting the release of neuropeptide Y, thereby reducing appetite, delaying gastric emptying, and decreasing intestinal motility
[3]. Wu Y, He H, Cheng Z, et al. The role of neuropeptide Y and peptide YY in the development of obesity via gut-brain axis[J]. Current Protein and Peptide Science, 2019, 20(7): 750-758.
[4]. Lafferty R A, Flatt P R, Irwin N. Emerging therapeutic potential for peptide YY for obesity-diabetes[J]. Peptides, 2018, 100: 269-274.
[5]. Nishizawa N, Niida A, Adachi Y, et al. Potent antiobesity effect of a short-length peptide YY-analogue continuously administered in mice[J]. Bioorganic & Medicinal Chemistry Letters, 2017, 27(16): 3829-3832.
[6]. Boland B B, Laker R C, O'Brien S, et al. Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic β-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries[J]. Molecular metabolism, 2022, 55: 101392.
Peptide YY (PYY), human是由肠道L细胞分泌的一种肽类激素 [1]。Peptide YY与下丘脑和迷走神经上的Y2受体结合，抑制神经肽Y的释放，从而降低食欲，延缓胃排空，降低肠道蠕动 [2-3]。Peptide YY主要用于肥胖、糖尿病和代谢综合征等疾病的研究 [4]。
在饮食诱导的肥胖小鼠模型中，持续给予Peptide YY（1mg/kg；sc；7d）可显著抑制摄食并诱导体重减轻，平均体重减轻约8.3%，显示出稳定且可持续的减食作用 [5]。在C57BLKS/J db/db小鼠中，Peptide YY（1mg/kg；sc；14d）与GLP-1联合使用可显著增加葡萄糖输注速率，增强全身葡萄糖处理率，并抑制肝脏葡萄糖生成，从而改善胰岛素敏感性 [6]。