Glutathione oxidized (L-Glutathione oxidized), an oxidized form of the antioxidant L-glutathione, acts as a signaling molecule that trigger the activation of antioxidant genes [1]. Glutathione oxidized can be reduced to GSH under the action of glutathione reductase in the presence of NADPH for cellular antioxidant defense [2]. Glutathione oxidized is a biomarker of oxidative stress status and can be used to evaluate oxidative stress may be involved in various diseases[3].
References:
[1] Pompella A, Visvikis A, Paolicchi A, et al. The changing faces of glutathione, a cellular protagonist[J]. Biochemical pharmacology, 2003, 66(8): 1499-1503.
[2] Owen J B, Butterfield D A. Measurement of oxidized/reduced glutathione ratio[M]//Protein misfolding and cellular stress in disease and aging: concepts and protocols. Totowa, NJ: Humana Press, 2010: 269-277.
[3] Rossi R, Dalle-Donne I, Milzani A, et al. Oxidized forms of glutathione in peripheral blood as biomarkers of oxidative stress[J]. Clinical chemistry, 2006, 52(7): 1406-1414.
Glutathione oxidized (L-Glutathione oxidized)，是抗氧化剂L-谷胱甘肽的氧化形式，作为一种信号分子，可触发抗氧化基因的激活[1]。在NADPH存在下，Glutathione oxidized可在谷胱甘肽还原酶的作用下被还原为GSH，以实现细胞的抗氧化防御[2]。Glutathione oxidized是氧化应激状态的生物标志物，可用于评估氧化应激可能参与的各种疾病[3]。