GPCR/G protein
GPCR/G protein(G 蛋白偶联受体/G 蛋白)
- Neuropeptide FF/AF Receptors(49)
- Formyl Peptide Receptors(11)
- 5-HT Receptor(504)
- Acetylcholine(29)
- Adenosine Deaminase(9)
- Adenosine Receptor(132)
- Adenosine Kinase(4)
- Adiponectin Receptor(3)
- Adrenergic Receptor(421)
- Adrenergic Transporters(5)
- Apelin Receptor(9)
- Angiotensin Receptor(114)
- Bombesin Receptors(23)
- Bradykinin Receptors(29)
- Calcitonin and Related Receptors(10)
- Cannabinoid Receptor(160)
- Calcimimetic Agent(2)
- CaSR(20)
- CCK1 Receptors(7)
- CCK2 Receptors(7)
- CCR(81)
- Chemokine Receptors(25)
- CRF1 Receptors(9)
- CRF2 Receptors(3)
- CXCR(80)
- CysLT1 receptor(1)
- Endothelin Receptor(52)
- EP1 Receptor(2)
- EP4 Receptor(3)
- ERRγ(1)
- ETA Receptors(5)
- ETB Receptors(5)
- Free Fatty Acid Receptors(18)
- Galanin Receptors(11)
- Ghrelin Receptors(12)
- GHSR(21)
- GIP Receptor(5)
- Glucagon Receptor(61)
- Glucocorticoid Receptor(97)
- GLUT1(1)
- Gonadotropin-Releasing Hormone Receptors(3)
- GPCR19(12)
- GPR109A(4)
- GPR119(10)
- GPR120(9)
- GPR35(10)
- GPR44(1)
- GPR55(11)
- Hydroxycarboxylic Acid Receptors(5)
- Leukotriene Receptor(58)
- LPA Receptor(12)
- LPL Receptor(60)
- LTD4 Receptor(1)
- mGluR (119)
- Melanin-concentrating Hormone Receptors(7)
- Melanocortin (MC) Receptors(58)
- Melatonin Receptors(24)
- Motilin Receptor(7)
- MT Receptor(1)
- Non-selective CRF(7)
- Neurotensin Receptors(24)
- NK2 Receptors(7)
- NK3 Receptor(6)
- NOP Receptor(20)
- NPY Receptors(28)
- Orexin(3)
- Orphan 7-TM Receptors(6)
- OX Receptor(48)
- Oxytocin Receptors(22)
- P2Y Receptor(62)
- PACAP Receptors(3)
- PAF Receptors(8)
- Peptide Receptors(14)
- PGD2 Receptor(1)
- Prostaglandin Receptor(172)
- Protease-Activated Receptors(10)
- Prostanoid Receptors
- RGS(2)
- S1P receptor(8)
- Secretin Receptors(1)
- Sensory Neuron-Specific Receptors(1)
- Somatostatin Receptor(39)
- Sigma Receptor(59)
- Vasopressin Receptor(35)
- 17,20-lyase(5)
- Ras(142)
- Urotensin-II Receptor(11)
- VIP Receptors(7)
- EBI2/GPR183(7)
- TSH Receptor(11)
- NK Receptor(1)
- GPR81(1)
- C3aR(1)
- CysLT2 receptor(1)
- S1P receptor inhibitor(22)
- CCKB(1)
- FFAR1 (GPR40)(20)
- GPR84(8)
- Neuromedin U Receptors(2)
- Kisspeptin Receptor(5)
- CRFR(25)
- RGS Protein(5)
- Urotensin Receptor(6)
- Cholecystokinin Receptor(25)
- GPR139(4)
- mAChR(185)
- MCHR1 (GPR24)(16)
- Neurokinin Receptor(75)
- Neuropeptide S Receptor(1)
- GPBA Receptor(1)
- Trace Amine 1 Receptor(2)
- GPCR protein(1)
- FFAR3(1)
- cGMP(27)
- GRK(1)
- GPR88
- Amylin Receptor
- Arrestin
- GCGR(2)
- GLP Receptor(2)
- Mas-related G-protein-coupled Receptor (MRGPR)
- Succinate Receptor 1
- PTHR(1)
- Protease Activated Receptor (PAR)(2)
- Free Fatty Acid Receptor(1)
- Formyl Peptide Receptor (FPR)(1)
GPCR/G protein 相关产品(3377)
- GC30792R121919 (NBI30775)CAS: 195055-03-9纯度: >99.50%
R121919 (NBI30775) (NBI30775) 是一种有效的小分子 CRF1 受体拮抗剂，对 CRF1 受体的 Ki 为 2 至 5 nM，对 CRF2 受体、CRF 结合蛋白或 70 种其他受体类型的活性弱 1000 倍以上.
- GC30796Nelotanserin (APD125)CAS: 839713-36-9纯度: >99.50%
Nelotanserin (APD125) 是一种有效的 5-HT2A 反向激动剂、中度有效的 5-HT2C 部分反向激动剂和弱 5-HT2B 反向激动剂，在 IP 积累试验中 IC50 分别为 1.7、79、791 nM。
- GC30812Imidafenacin (KRP-197)CAS: 170105-16-5纯度: >98.00%
Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). IC50 value: 0.3 nM(M3).
- GC30819JNJ-40411813 (ADX-71149)CAS: 1127498-03-6纯度: >98.50%
JNJ-40411813 (ADX-71149) (ADX-71149) 是一种新型的代谢型谷氨酸 2 受体 (mGlu2R) 正变构调节剂，EC50 为 147 nM。
- GC30822Solifenacin (YM905)CAS: 242478-37-1纯度: >98.00%
Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.
- GC30826Temanogrel (APD791)CAS: 887936-68-7纯度: >98.50%
Temanogrel (APD791) 是一种高度选择性的 5-HT2A 受体拮抗剂，Ki 为 4.9 nM。
- GC30836MK-7622 (M1 receptor modulator)CAS: 1227923-29-6纯度: >98.50%
A positive allosteric modulator of M 1 mAChRs
- GC30875CCG 203769CAS: 410074-60-1纯度: >99.50%
CCG-203769是一种选择性的G蛋白信号调节因子(RGS4)抑制剂，CCG-203769阻断RGS4-Gαo蛋白-蛋白相互作用，IC50为17nM。
- GC308888-OH-DPAT (8-Hydroxy-DPAT)CAS: 78950-78-4纯度: >95.00%
8-OH-DPAT 是5-HT1A 激动剂， pIC50 值为 8.19 ，此外8-OH-DPAT对5-HT1B(pIC50 , 5.42)和5-HT (pIC50 <5)受体亲和力都很弱 。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC30781 | Tasimelteon (BMS-214778) | 609799-22-6 | >99.00% | |
A melatonin receptor agonist | ||||
| GC30787 | Sertindole (Lu 23-174) | 106516-24-9 | >99.50% | |
An atypical antipsychotic | ||||
| GC30791 | Atipamezole (MPV 1248) | 104054-27-5 | >99.00% | |
An α 2A -AR antagonist | ||||
| GC30792 | R121919 (NBI30775) | 195055-03-9 | >99.50% | |
R121919 (NBI30775) (NBI30775) 是一种有效的小分子 CRF1 受体拮抗剂，对 CRF1 受体的 Ki 为 2 至 5 nM，对 CRF2 受体、CRF 结合蛋白或 70 种其他受体类型的活性弱 1000 倍以上. | ||||
| GC30793 | ADX88178 | 1235318-89-4 | >99.50% | |
ADX88178是一种有效的代谢型谷氨酸受体4(mGluR4)正变构调节剂，作用于人mGluR4，EC50为4nM。 | ||||
| GC30796 | Nelotanserin (APD125) | 839713-36-9 | >99.50% | |
Nelotanserin (APD125) 是一种有效的 5-HT2A 反向激动剂、中度有效的 5-HT2C 部分反向激动剂和弱 5-HT2B 反向激动剂，在 IP 积累试验中 IC50 分别为 1.7、79、791 nM。 | ||||
| GC30797 | lumateperone Tosylate (ITI-007) | 1187020-80-9 | >99.00% | |
An atypical antipsychotic | ||||
| GC30809 | VU0467154 | 1451993-15-9 | >99.50% | |
A positive allosteric modulator of the M 4 muscarinic acetylcholine receptor | ||||
| GC30812 | Imidafenacin (KRP-197) | 170105-16-5 | >98.00% | |
Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). IC50 value: 0.3 nM(M3). | ||||
| GC30819 | JNJ-40411813 (ADX-71149) | 1127498-03-6 | >98.50% | |
JNJ-40411813 (ADX-71149) (ADX-71149) 是一种新型的代谢型谷氨酸 2 受体 (mGlu2R) 正变构调节剂，EC50 为 147 nM。 | ||||
| GC30822 | Solifenacin (YM905) | 242478-37-1 | >98.00% | |
Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle. | ||||
| GC30826 | Temanogrel (APD791) | 887936-68-7 | >98.50% | |
Temanogrel (APD791) 是一种高度选择性的 5-HT2A 受体拮抗剂，Ki 为 4.9 nM。 | ||||
| GC30829 | IPSU | 1373765-19-5 | >98.00% | |
An orexin receptor 2 antagonist | ||||
| GC30832 | GSK1059865 | 1191044-58-2 | >99.50% | |
GSK1059865是有效地食欲素1受体(orexin1receptor)拮抗剂。 | ||||
| GC30836 | MK-7622 (M1 receptor modulator) | 1227923-29-6 | >98.50% | |
A positive allosteric modulator of M 1 mAChRs | ||||
| GC30849 | DREADD agonist 21 | 56296-18-5 | >99.50% | |
A muscarinic hM3Dq DREADD agonist | ||||
| GC30851 | Tecadenoson (CVT-510) | 204512-90-3 | >99.50% | |
An adenosine A 1 receptor agonist | ||||
| GC30859 | AC260584 | 560083-42-3 | >99.00% | |
AC260584是M1毒蕈碱受体变构激动剂，pEC50值为7.6。 | ||||
| GC30861 | Pavinetant (MLE-4901) | 941690-55-7 | >99.50% | |
An NK 3 receptor antagonist | ||||
| GC30863 | CP 376395 (CP-316311) | 175140-00-8 | >99.50% | |
A CRF 1 antagonist | ||||
| GC30875 | CCG 203769 | 410074-60-1 | >99.50% | |
CCG-203769是一种选择性的G蛋白信号调节因子(RGS4)抑制剂，CCG-203769阻断RGS4-Gαo蛋白-蛋白相互作用，IC50为17nM。 | ||||
| GC30880 | LP-211 | 1052147-86-0 | >99.50% | |
LP-211是一种选择性的、可透过血脑屏障的5-HT 7 受体（K i =0.58nM）激动剂，选择性高于5-HT 1A 受体（K i =188nM）和D2受体（K i =142nM）。 | ||||
| GC30888 | 8-OH-DPAT (8-Hydroxy-DPAT) | 78950-78-4 | >95.00% | |
8-OH-DPAT 是5-HT1A 激动剂， pIC50 值为 8.19 ，此外8-OH-DPAT对5-HT1B(pIC50 , 5.42)和5-HT (pIC50 <5)受体亲和力都很弱 。 | ||||
| GC30890 | RG7713 (RO5028442) | 920022-47-5 | >99.50% | |
A vasopressin V 1a receptor antagonist | ||||