GlpBio

JNJ-40411813 (ADX-71149)

目录号: GC30819纯度: >98.50%同义词: ADX-71149
JNJ-40411813 (ADX-71149) (ADX-71149) 是一种新型的代谢型谷氨酸 2 受体 (mGlu2R) 正变构调节剂，EC50 为 147 nM。
JNJ-40411813 (ADX-71149)
Cas No.: 1127498-03-6
规格价格库存数量操作
1mg¥553.00现货
1
5mg¥1,339.00现货
1
10mg¥2,127.00现货
1
25mg¥3,353.00现货
1
50mg¥4,647.00现货
1
10mM (in 1mL DMSO)¥1,016.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.IC50 value: 147 nM(EC50)Target: mGlu2RJNJ-40411813 displayed an optimal interplay between potency, selectivity, favorable ADMET/PK and cardiovascular safety profile, and central EEG activity. JNJ-40411813 has been investigated in the clinic for schizophrenia and anxious depression disorders.

[1]. Cid JM, et al. Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor. J Med Chem. 2014 Aug 14;57(15):6495-512.

产品文档 Product Documents

Purity:>98.50%

化学性质Chemical Properties

CAS 号
1127498-03-6
同义词
ADX-71149
SMILES
O=C1C(Cl)=C(N2CCC(C3=CC=CC=C3)CC2)C=CN1CCCC
分子式
C20H25ClN2O
分子量
344.88 g/mol
溶解性
DMSO : 25 mg/mL (72.49 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol