GlpBio

Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid)

目录号: GC30946纯度: >99.00%同义词: 丙环定盐酸盐; Tricyclamol hydrochloride; (±)-Procyclidine hydrochloride
A muscarinic acetylcholine receptor antagonist
Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid)
Cas No.: 1508-76-5
规格价格库存数量操作
100mg¥540.00现货
1
10mM (in 1mL DMSO)¥594.00现货
1
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产品描述 Description

Procyclidine is an antagonist of muscarinic acetylcholine receptors (Kis = 4.47, 42.66, 7.24, 6.03, and 4.79 nM for M1-5 receptors, respectively).1 It increases fine motor activity counts (ED50 = 1.74 mg/kg) without affecting ambulatory activity in rats in a home-cage activity test.2 Formulations containing procyclidine have been used in the treatment of parkinsonism and extrapyramidal dysfunction.

1.Lazareno, S., Buckley, N.J., and Roberts, F.F.Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cellMol. Pharmacol.38(6)805-815(1990) 2.Sipos, M.L., Burchnell, V., and Galbicka, G.Dose-response curves and time-course effects of selected anticholinergics on locomotor activity in ratsPsychopharmacology147(3)250-256(1999)

实验参考方法 Experimental Reference Method

Animal experiment:

Rats[1] Adult Sprague-Dawley female rats (weight 300-330 g) are used. Procyclidine given systemically causes a transient increase in locomotor activity (mainly non-ambulatory fine movements) in adult rats. Locomotor activity data (ambulations, fine movements) are evaluated using a two-way ANOVA to test whether co-administration of clonidine (0.025 mg/kg) with various doses of Procyclidine (10, 25, 50 and 75 mg/kg) altered the activity levels compared to the same doses of Procyclidine administered alone. A one-way ANOVA and subsequent comparisons are also conducted to establish whether the activity levels for each treatment group are different from saline controls.

References:

[1]. Jevtovic-Todorovic V, et al. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Neuropharmacology. 2003 May;44(6):739-48.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
1508-76-5
同义词
丙环定盐酸盐; Tricyclamol hydrochloride; (±)-Procyclidine hydrochloride
SMILES
OC(C1=CC=CC=C1)(C2CCCCC2)CCN3CCCC3.[H]Cl
分子式
C19H30ClNO
分子量
323.9 g/mol
溶解性
DMSO : 10.66 mg/mL (32.91 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol