Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC61593 DAPK Substrate Peptide TFA DAPKSubstratePeptideTFA是一种合成的死亡相关蛋白激酶(DAPK)的肽底物，Km为9μM。
GC61580 Sepimostat
司匹司他,FUT-187 free base
Sepimostat(FUT-187freebase)通过拮抗NR2BN-methyl-D-aspartate受体发挥神经保护作用，作用位点在NR2B亚基的Ifenprodil结合位点。Sepimostat抑制Ifenprodil结合的Ki值为27.7 µM。
GC61570 Sepimostat dimethanesulfonate
6-甲脒基萘-2-基4-((4,5-二氢-1H-咪唑-2-基)氨基)苯甲酸酯二甲磺酸盐,FUT-187
Sepimostatdimethanesulfonate(FUT-187)通过拮抗NR2BN-methyl-D-aspartate受体发挥神经保护作用，作用位点在NR2B亚基的Ifenprodil结合位点。Sepimostatdimethanesulfonate抑制Ifenprodil结合的Ki值为27.7 µM。
GC61566 Pseudocoptisine chloride
盐酸异黄连碱; Isocoptisine chloride
Pseudocoptisine chloride (Isocoptisine chloride) is a quaternary alkaloid with benzylisoquinoline skeleton isolated from Corydalis Tuber, inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM, showing anti-inflammatory and anti-amnestic effects.
GC61565 Indophagolin
5-溴-N-(4-氯-3-(三氟甲基)苯基)-1-(环丙烷羰基)吲哚啉-6-磺酰胺
Indophagolin, a potent indoline-containing autophagy inhibitor with IC50 of 140 nM, antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively, also has a strong antagonistic effect on serotonin receptor 5-HT6 with IC50 of 1.0 μM.
GC61539 Betazole
倍他唑,Ametazole
Betazole Dihydrochloride (Ametazole, 2-(3-Pyrazolyl)ethanamine) is a histamine H2 agonist used clinically to test gastric secretory function.
GC61521 Calmodulin-Dependent Protein Kinase II(290-309) acetate Calmodulin-DependentProteinKinaseII(290-309)acetate是有效的CaMK拮抗剂，抑制抑制Ca2+/钙调蛋白依赖性蛋白激酶II的IC50值为52nM。
GC61486 Neurokinin A TFA
Substance K TFA; Neurokinin α TFA; Neuromedin L TFA
Neurokinin A TFA是一种内源性的速激肽家族神经肽，是神经激肽2受体（NK2R）的强效选择性激动剂。
GC61476 Fmoc-Ala-Glu-Asn-Lys-NH2 Fmoc-Ala-Glu-Asn-Lys-NH2是一种选择性天冬酰胺内肽酶AEP抑制肽，可抑制淀粉样前体蛋白APP裂解。AEP是一种pH值控制的半胱氨酸蛋白酶，在衰老过程中被激活并介导APP蛋白水解过程。
GC61467 Niaprazine
尼普拉嗪
Niaprazine是一种具有强效镇静作用的组胺H1受体(histamineH1-receptor)拮抗剂。Niaprazine具有抗组胺和抗血清素活性，并可用于睡眠障碍的研究。
GC61464 GR 125743 GR125743是一种选择性的5-HT1B/1D受体拮抗剂，与野生型的人h5-HT1B和5-HT1D结合的pKi分别为8.85和8.31。GR125743可用于帕金森病和心血管疾病的研究。
GC61453 Penconazole
戊菌唑
Penconazole是一种典型的三唑类杀菌剂(fungicide)，主要用于苹果、葡萄、蔬菜等地的白粉病防治。Penconazole抑制真菌固醇生物合成。Penconazole降低大鼠大脑和小脑AChE活性。
GC61446 (Rac)-Lanicemine
(Rac)-拉尼西明; (Rac)-AZD6765
(Rac)-Lanicemine((Rac)-AZD6765)是Lanicemine的外消旋体。Lanicemine(AZD6765)是一种低捕获的NMDA受体拮抗剂，Ki为0.56-2.1 μM。CHO和爪蟾卵母细胞中，IC50分别为4-7μM和6.4μM。具有抗抑郁作用。
GC61436 Gallic acid hydrate
没食子酸-水合物; 3,4,5-Trihydroxybenzoic acid hydrate
A phenol with diverse biological activities
GC61401 Oxatomide
欧诗美锭
Oxatomide是一种口服活性的H1受体拮抗剂（抗组胺药）。
GC19706 Propacetamol hydrochloride
盐酸丙帕他莫
A prodrug form of acetaminophen
GC19695 2,8-Quinolinediol
2,8-喹啉二醇
GC19686 DL-Pyroglutamic acid
DL-焦谷氨酸
GC48962 Heptanoic Acid
庚酸
A medium-chain fatty acid
GC48956 Penicillamine-d3
D-(-)-Penicillamine-d3
An internal standard for the quantification of penicillamine
GC48954 CP21 An iron chelator
GC48937 L-Tyrosine-13C9,15N
DL-酪氨酸 13C9,15N
An internal standard for the quantification of L-tyrosine
GC48930 Tryptamine-d4 (hydrochloride)
D4色胺盐酸
An internal standard for the quantification of tryptamine
GC48912 RO5166017 A TAAR1 agonist
GC48907 Metaxalone-d6
AHR438-d6; NSC170959-d6
An internal standard for the quantification of metaxalone
GC48897 Homocarnosine
高肌肽; L-Homocarnosine; γ-Aminobutyryl-L-histidine
A dipeptide
GC48895 Rufinamide-15N-d2
[15N,2H2]-卢非酰胺
An internal standard for the quantification of rufinamide
GC48892 NSC 19005
N-甲基-N,N-双(2-吡啶基乙基)胺,NSC19005
A potential impurity found in commercial preparations of betahistine
GC48889 Methazolamide-d6
L584601-d6
An internal standard for the quantification of methazolamide
GC48886 Carbamazepine-d10
5H-二苯并[B,F]氮杂卓-5-甲酰胺-D10,CBZ-d10; NSC 169864-d10
Carbamazepine-d10是一种稳定同位素标记的内标化合物，在定量分析中用作GC-MS、LC/MS和高通量解吸电喷雾电离（DESI）分析的内标。
GC48881 Tasimelteon-d5
BMS-214778-d5; VEC-162-d5
An internal standard for the quantification of tasimelteon
GC48880 7-Methoxyflavone
7-甲氧基黄酮
A flavone with diverse biological activities
GC48861 Phenytoin-d10
苯妥英D10,5,5-Diphenylhydantoin-d10
An internal standard for the quantification of phenytoin
GC48853 Pirlindole-d4 (hydrochloride) An internal standard for the quantification of pirlindole
GC48847 Oxprenolol-d7
dl-Alprenolol-d7, dl-Oxprenolol-d7
An internal standard for the quantification of oxprenolol
GC48843 5α-Androst-16-en-3α-ol
(3α,5α)-16-烯-3-甾醇
A pheromone with diverse biological activities
GC48835 Diphenylpyraline
二苯拉林；双苯拉林
A histamine H₁ receptor antagonist
GC48827 Flufenamic Acid-d4
FFA-d4, Fluphenamic Acid-d4
An internal standard for the quantification of flufenamic acid
GC48824 4-hydroxy Estrone
4-羟基雌酮; 4-OHE1
A metabolite of estrone
GC48821 11-cis Retinol
11-cis Vitamin A Alcohol
An isomer of vitamin A
GC48814 Mesembrine
松叶菊碱,(+)-Mesembrine
An alkaloid with 5-HT reuptake inhibitory activity
GC48805 Methapyrilene (hydrochloride)
盐酸美沙吡林,Thenylpyramine hydrochloride
An H₁ receptor antagonist and non-genotoxic carcinogen
GC48804 N-desmethyl Olanzapine
N-去甲基奥氮平
A major metabolite of olanzapine
GC48801 Nylidrin
脑清
An agonist of β-ARs and antagonist of NR1A/2B subunit-containing NMDA receptors
GC48790 Ticlopidine-d4 (hydrochloride)
盐酸噻氯匹定 d4 (盐酸盐)
An internal standard for the quantification of ticlopidine
GC48776 Olanzapine Lactam Impurity
奥氮平内酰胺
A potential impurity found in commercial preparations of olanzapine
GC48760 Maprotiline-d3 (hydrochloride)
Ba 34276-d3
An internal standard for the quantification of maprotiline
GC48752 Isothipendyl (hydrochloride)
盐酸异西喷他
An antihistamine
GC48677 Sulindac-d3
MK-231-d3
An internal standard for the quantification of sulindac
GC48661 Methylatropine (nitrate)
甲硝阿托品
A muscarinic acetylcholine receptor antagonist