GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC35075 structure
    GC3507520-HETE
    CAS: 79551-86-3
    纯度: >98.00%

    A cytochrome P450 (CYP450) metabolite of arachidonic acid

  • GC35079 structure
    GC3507924, 25-Dihydroxy VD2
    CAS: 58050-55-8
    纯度: >99.50%

    24, 25-Dihydroxy VD2 是一种维生素D2的羟基化代谢产物，是合成的维生素D类似物。

  • GC35081 structure
    GC3508125,26-Dihydroxyvitamin D3
    CAS: 29261-12-9
    纯度: >95.00%

    25,26-Dihydroxyvitamin D3是维生素D3代谢物。

  • GC35090 structure
    GC350902-Hydroxy atorvastatin calcium salt
    CAS: 265989-46-6
    纯度: >98.00%

    An active metabolite of atorvastatin

  • GC35095 structure
    GC350952-Phospho-L-ascorbic acid trisodium salt
    CAS: 66170-10-3
    纯度: >97.00% / >99.00%

    Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products.

  • GC35106 structure
    GC351063-Dehydrotrametenolic acid
    CAS: 29220-16-4
    纯度: >98.00%

    3-Dehydrotrametenolic acid，分离于茯苓菌核，是一种乳酸脱氢酶 (LDH) 抑制剂。3-Dehydrotrametenolic acid 促进体外脂肪细胞分化，在体内起胰岛素增敏剂的作用。3-Dehydrotrametenolic acid 诱导细胞凋亡，具有抗癌活性。

  • GC35111 structure
    GC351113-Epiursolic Acid
    CAS: 989-30-0
    纯度: >99.00%

    A pentacyclic triterpenoid with diverse biological activities

  • GC35126 structure
    GC351264-​Hydroxyphenylpyruvic acid
    CAS: 156-39-8
    纯度: >96.00%

    4-Hydroxyphenylpyruvic acid (4-HPPA), an abundant colon metabolite of polyphenols, is a potent scavenger that suppresses levels of free radicals and cyclooxygenase-2 (COX-2) and contributes to reduced risk of colon cancer development.

  • GC35131 structure
    GC351314-Hydroxycoumarin
    CAS: 1076-38-6
    纯度: >98.00%

    A coumarin

  • GC35134 structure
    GC351344-Methoxybenzaldehyde
    CAS: 123-11-5

    p-Anisaldehyde (4-Methoxybenzaldehyde, Anisaldehyde, Anisic aldehyde, P-Methoxybenzaldehyde, 4-Anisaldehyde), an extract from Pimpinella anisum seeds, exhibits antifungal activity against a number of yeast and mold strains in laboratory media, fruit purees and fruit juices.

  • GC35135 structure
    GC351354-Methoxycinnamic acid
    CAS: 830-09-1

    4-Methoxycinnamic acid 是一种天然苯丙烷类化合物。

  • GC35139 structure
    GC351394-Methylesculetin
    CAS: 529-84-0
    纯度: >95.00%

    4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level.

  • GC35150 structure
    GC351505,7,4'-Trimethoxyflavone
    CAS: 5631-70-9
    纯度: >99.50%

    4',5,7-Trimethoxyflavone (5,7,4'-Trimethoxyflavone, TMF) is a flavonoid isolated from Kaempferia parviflora (KP) that induces apoptosis. 4',5,7-Trimethoxyflavone increases sub-G1 phase, DNA fragmentation, annexin-V/PI staining and Bax/Bcl-xL ratio, activates caspase-3 and degrades poly (ADP-ribose) polymerase (PARP) protein.

  • GC35152 structure
    GC351525,6-Dihydro-5-methyluracil
    CAS: 696-04-8
    纯度: >99.00%

    Dihydrothymine is an intermediate breakdown product of thymine.

  • GC35156 structure
    GC351565-Amino-3H-imidazole-4-Carboxamide
    CAS: 360-97-4

    4-Amino-5-imidazolecarboxamide is an imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides.

  • GC35157 structure
    GC351575'-GTP trisodium salt
    CAS: 36051-31-7
    纯度: >98.00%

    5'-GTP trisodium salt是G蛋白信号传导的激活剂，也是DNA和RNA生物合成的高能核苷酸单体。

  • GC35159 structure
    GC351595'-Guanylic acid disodium salt
    CAS: 5550-12-9
    纯度: >98.00%

    A nucleotide

  • GC35166 structure
    GC351665-Methylcytosine
    CAS: 554-01-8
    纯度: >99.50%

    5-Methylcytosine, a methylated form of the DNA base cytosine, is a major epigenetic mark in the nuclear DNA in mammals and may be involved in the regulation of gene transcription.

  • GC35168 structure
    GC351685-O-Demethylnobiletin
    CAS: 2174-59-6
    纯度: >99.50%

    A flavonoid with diverse biological activities

  • GC35204 structure
    GC352048-Hydroxyguanine
    CAS: 5614-64-2

    8-Hydroxyguanine是由活性氧物质产生的主要诱变前损伤。 它导致G-T和A-C置换。

  • GC35219 structure
    GC35219Abiraterone metabolite 1
    CAS: 1940176-03-3
    纯度: >99.50%

    Abiraterone metabolite 1 是 abiraterone 的 5β-还原代谢物。Abiraterone 是一种甾体药物，可抑制 CYP17A1，阻断雄激素的合成，延长前列腺癌的生存期。

  • GC35221 structure
    GC35221ABT-046
    CAS: 1031336-60-3
    纯度: >98.50%

    ABT-046 是一种具有口服活性的选择性二酰基甘油酰基转移酶 1 (DGAT-1) 抑制剂，IC50 为 8 nM。

  • GC35228 structure
    GC35228Aceglutamide
    CAS: 2490-97-3
    纯度: >98.00%

    An acetylated form of L-glutamine

  • GC35261 structure
    GC35261Aflatoxin B1
    CAS: 1162-65-8
    纯度: >98.00%

    黄曲霉毒素B1作为一类由曲霉属真菌产生的致癌真菌毒素，常导致人和动物发生肝细胞癌。