Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC40141 C18 Phytoceramide-d3 (t18:0/18:0-d3)
Cer(t18:0/18:0) - d3, Ceramide (t18:0/18:0)- d3, N-Octadecanoyl Phytosphingosine- d3, C18:0 Phytoceramide- d3, N-Stearoyl Phytosphingosine- d3
An internal standard for the quantification of C18 phytoceramide
GC40125 Z-VA-DL-D(OMe)-FMK (trifluoroacetate salt)
Caspase-1 Inhibitor V, Z-VAD-FMK, Z-VAD(OMe)-FMK, Z-Val-Ala-DL-Asp(OMe)-Fluoromethyl Ketone
A pan-caspase inhibitor
GC40123 Ac-AAVALLPAVLLALLAP-VAD-CHO (trifluoroacetate salt)
Caspase Inhibitor II, Ac-AAVALLPAVLLALLAP-VAD-aldehyde, Ac-AAVALLPAVLLALLAPVAD-CHO
A non-selective caspase inhibitor
GC40122 Ac-AAVALLPAVLLALLAP-DEVD-CHO (trifluoroacetate salt)
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO, Ac-AAVALLPAVLLALLAP-DEVD-aldehyde, Ac-AAVALLPAVLLALLAPDEVD-CHO, Caspase-3 Inhibitor I, DEVD-CHO-CPP 32
A caspase-3 inhibitor
GC40118 Ac-AAVALLPAVLLALLAP-IETD-CHO (trifluoroacetate salt)
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO, Caspase-8 Inhibitor I
An inhibitor of caspase-8 and granzyme B
GC40101 IMP-1088 IMP-1088是一种针对人类N-豆蔻酰转移酶NMT1和NMT2的皮摩尔级双重抑制剂，对NMT1的IC₅₀值为0.24nM，对NMT2的IC₅₀值 < 1nM。
GC40099 Leukotriene D4 MaxSpec® Standard
LTD4
An active metabolite of LTC₄ and a constituent of SRS-A
GC40097 4-HOBA
4-羟基苄胺
An isomer of 2-HOBA
GC40087 7α-hydroxy-4-Cholesten-3-one
7-羟基-4-胆甾烯-3-酮
7α-Hydroxy-4-cholesten-3-one是一种由胆固醇合成胆汁酸的中间体，是pregnane X receptor（PXR）激动剂。
GC40038 Heptanoyl-L-carnitine (chloride)
C7:0 Carnitine, CAR 7:0, L-Carnitine heptanoyl ester, L-Heptanoylcarnitine
Heptanoyl-L-carnitine (chloride)是L-肉碱的衍生物，L-肉碱是一种在脂肪酸转运至线粒体进行β-氧化过程中发挥关键作用的化合物。Heptanoyl-L-carnitine (chloride)在生物化学研究中被广泛用于研究代谢过程和线粒体功能。
GC40037 Linoleoyl-L-carnitine (chloride)
CAR 18:2, C18:2 Carnitine, L-Carnitine linoleoyl ester, L-Linoleoylcarnitine
A long-chain acylcarnitine
GC40032 Antipain (hydrochloride)
抗痛素二盐酸盐
Antipain (hydrochloride)是一种可逆性蛋白酶抑制剂。
GC40029 9(S),10(S),13(S)-TriHOME An oxylipin
GC40018 Donepezil N-oxide
多奈哌齐N氧化物
An active metabolite of donepezil
GC40008 Fuscin
暗褐菌素
A fungal metabolite with diverse biological activities
GC40007 Malformin A
Malformin A1
A cyclopentapeptide fungal metabolite with diverse biological activities
GC34417 (R,S)-Ivosidenib ((R,S)-AG-120) (R,S)-Ivosidenib是一种异柠檬酸脱氢酶(IDH1)抑制剂。
GC34414 AZ7550 Mesylate (AZ7550 trimesylate salt) An active metabolite of AZ 9291
GC34413 Lurasidone Metabolite 14283 D8 LurasidoneMetabolite14283D8是LurasidoneMetabolite14283的氘代化合物标准品。
GC34412 Lurasidone metabolite 14326 hydrochloride Lurasidonemetabolite14326(hydrochloride)是一种非典型抗精神病药物Lurasidone的活性代谢物。
GC34411 Lurasidone Metabolite 14326 D8 LurasidoneMetabolite14326D8是LurasidoneMetabolite14326的氘代化合物标准品。
GC34410 N-desmethyl Netupitant D6 N-desmethylNetupitantD6是N-desmethylNetupitant的氘代化合物标准品。
GC34409 Netupitant N-oxide D6 NetupitantN-oxideD6是NetupitantN-oxide的氘代化合物标准品。
GC34408 Monohydroxy Netupitant D6 MonohydroxyNetupitantD6是MonohydroxyNetupitant的氘代化合物标准品。
GC34373 Dabigatran D4 hydrochloride (BIBR-953 D4 hydrochloride) DabigatranD4盐酸盐是Dabigatran氘代化合物标准品。
GC34358 Leu-AMS R enantiomer Leu-AMSRenantiomer是Leu-AMS的R对映体。Leu-AMS是亮氨酰-tRNA合成酶(LRS)的有效抑制剂并抑制细菌的生长。
GC34331 Gln-AMS TFA Gln-AMS(TFA)是Ia类型的氨酰基-tRNA合成酶(AARS)抑制剂。Gln-AMS抑制谷氨酰胺酰-tRNA合成酶的Ki值为1.32µM。
GC34324 ZK824859 hydrochloride ZK824859hydrochloride是一种口服有效的选择性尿激酶型纤溶酶原激活剂(uPA)抑制剂，用于人uPA，tPA和纤溶酶，IC50分别为79nM，1580nM和1330nM。
GC34287 AZ7550 hydrochloride An active metabolite of AZ 9291
GC34255 TP508 TP508是由23个氨基酸残基构成的多肽，它代表了人凝血素的第508-530位氨基酸序列，被认为是高亲和性受体与凝血素的结合域。
GC34193 2-(4-Methoxyphenyl)acetic acid (4-Methoxyphenylacetic acid)
对甲氧基苯乙酸,4-Methoxyphenylacetic acid
2-(4-Methoxyphenyl)acetic acid (p-Anisylacetic acid, 4-Methoxyphenylacetic acid) is a 4-O-Methylated catecholamine metabolite found in normal human urine, cerebrospinal fluid and brain tissue.
GC34181 Tauroursodeoxycholate (TUDCA)
牛磺熊去氧胆酸; Tauroursodeoxycholic acid; TUDCA; UR 906
牛磺酸脱氧胆酸盐(TUDCA)是包括肝细胞在内的多种细胞的细胞保护剂,也是癌症细胞凋亡的诱导剂。
GC34179 2-Methoxybenzoic acid (NSC 3778)
邻甲氧基苯甲酸,NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether
2-Methoxybenzoic acid (o-Anisic acid) is a flavouring agent.
GC34134 Glycocholic acid
甘氨胆酸
Glycocholic acid是一种参与脂肪乳化的结晶胆汁酸，是胆酸与甘氨酸的结合物，它以钠盐的形式存在于哺乳动物的胆汁中。
GC34123 Deoxycytidine triphosphate (dCTP)
脱氧胞苷三磷酸; dCTP; 2′-Deoxycytidine-5′-triphosphate
脱氧胞苷三磷酸 (dCTP) (dCTP) 是一种核苷三磷酸，可用于 DNA 合成。
GC34113 N-(5-Aminopentyl)acetamide (Monoacetylcadaverine)
N-(5-氨基戊基)乙酰胺,Monoacetylcadaverine
N-(5-Aminopentyl)acetamide (Monoacetylcadaverine, N-Acetylcadaverine) is the acetylated form of the polyamine cadaverine, which is a foul-smelling diamine compound.
GC34092 Glycochenodeoxycholic acid (Chenodeoxycholylglycine)
甘氨鹅脱氧胆酸; Chenodeoxycholylglycine
A quantitative analytical standard guaranteed to meet MaxSpec^? identity, purity, stability, and concentration specifications
GC34052 Fosfructose (Diphosphofructose)
二磷酸果糖; Diphosphofructose; Esafosfan; FDP
Fosfructose (Diphosphofructose) (Diphosphofructose;Esafosfan;FDP) 是一种具有细胞保护作用的天然磷酸糖，可用于治疗心血管缺血、镰状细胞性贫血和哮喘。
GC34040 Fosfructose trisodium (Diphosphofructose (trisodium))
D-果糖-1,6-二磷酸三钠盐,Diphosphofructose trisodium; Esafosfan trisodium; FDP trisodium
D-Fructose-1,6-diphosphate trisodium salt octahydrate (FBP trisodium salt octahydrate), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway.
GC34032 Napsagatran hydrate (Ro 46-6240 hydrate)
奈沙加群,Ro 46-6240 hydrate; Ro 46-6240/010 hydrate
Napsagatran hydrate (Ro 46-6240 hydrate) 是一种新型的特异性凝血酶抑制剂。
GC34027 N-Acetylprocainamide (Acecainide)
N-乙酰普鲁卡因胺; Acecainide; NAPA
N-Acetylprocainamide (Accecainide) 是一种 III 类抗心律失常药，可阻断 K+ 通道。
GC34021 Vitamin K4 (acetomenaphthone)
维生素K4; acetomenaphthone
A synthetic form of vitamin K
GC34019 Omapatrilat (BMS-186716)
BMS-186716
An ACE and NEP inhibitor
GC34016 11beta-Hydroxyprogesterone (11β-Hydroxyprogesterone)
11β-羟孕酮; 11β-Hydroxyprogesterone
A metabolite of progesterone
GC34011 FX-11 (LDHA Inhibitor FX11)
LDHA Inhibitor FX11
FX-11（LDHA 抑制剂 FX11）被发现是一种有效的竞争性人 LDH-A 的 NADH 结合口袋抑制剂。
GC33995 DL-3-Phenyllactic acid
DL-Β-苯乳酸
DL-3-Phenyllacticacid是一种广谱抗菌化合物。
GC33991 Hydroxyphenyllactic acid
3-(4-羟基苯基)乳酸
Hydroxyphenyllactic acid是一种酪氨酸代谢物。
GC33976 4',7-Dimethoxyisoflavone (Dimethoxydaidzein)
4',7-二甲氧基异黄酮; Dimethoxydaidzein
4',7-Dimethoxyisoflavone, isolated from the leaves of Albizzia lebbeck, shows antifungal activity in vitro.
GC33968 DPC-681 (DPH-153893)
DPH-153893
DPC-681 (DPH-153893) 是一种有效的选择性 HIV 蛋白酶抑制剂，对野生型 HIV-1 的 IC90 为 4 至 40 nM。
GC33930 Desaminotyrosine (3-(4-Hydroxyphenyl)propionic acid)
对羟基苯丙酸; 3-(4-Hydroxyphenyl)propionic acid
Phloretic acid (Desaminotyrosine, Hydro-p-coumaric acid, Phloretate, 3-(4-Hydroxyphenyl)propanoic acid) is a naturally occurring phenolic compound which can be produced by the hydrogenation of p-coumaric acid or synthesized from phloretin, a by-product of apple tree leaves.