N-acetyl-L-Glutamine is an acetylated form of the conditionally essential amino acid L-glutamine . It decreases infarct volume and prevents neuronal apoptosis in the substantia nigra in a rat model of cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).1 N-acetyl-L-Glutamine (8.28 g/animal per day) prevents decreases in body weight in protein-energy malnourished pigs.2 Formulations containing N-acetyl-L-glutamine have been used as dietary supplements.
1.Zhang, R., Yang, N., Ji, C., et al.Neuroprotective effects of Aceglutamide on motor function in a rat model of cerebral ischemia and reperfusionRestor. Neurol. Neurosci.33(5)741-759(2015) 2.López-Pedrosa, J.M., Manzano, M., Baxter, J.H., et al.N-acetyl-L-glutamine, a liquid-stable source of glutamine, partially prevents changes in body weight and on intestinal immunity induced by protein energy malnutrition in pigsDig. Dis. Sci.52(3)650-658(2007)