GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC35262 structure
    GC35262Afzelin
    CAS: 482-39-3
    纯度: >98.00%

    A polyphenolic glycoside flavone with diverse biological activities

  • GC35295 structure
    GC35295Allopurinol riboside
    CAS: 16220-07-8
    纯度: >98.00%

    A ribonucleoside

  • GC35300 structure
    GC35300Aloin(mixture of A&B)
    CAS: 8015-61-0
    纯度: >95.00%

    An anthroquinone with diverse biological activities

  • GC35320 structure
    GC35320Aminoadipic acid
    CAS: 542-32-5
    纯度: >98.00% / >97.00%

    DL-2-Aminoadipic acid is an excitatory amino acid analogue, which functions as a glutamine synthetase inhibitor.

  • GC35321 structure
    GC35321Aminomalonic acid
    CAS: 1068-84-4
    纯度: >98.00%

    Aminomalonic acid (Aminomalonate, Aminopropanedioic acid) is an amino dicarboxylic acid. It has a role as a human metabolite and a Daphnia magna metabolite.

  • GC35339 structure
    GC35339Anandamide
    CAS: 94421-68-8
    纯度: >98.00%

    Anandamide是一种来源于含花生四烯酸膜脂的内源性大麻素，通过结合并激活CB1和CB2大麻素受体以及香草素瞬时受体电位通道1（TRPV1）受体发挥作用。

  • GC35355 structure
    GC35355Angiotensin III
    CAS: 12687-51-3

    Angiotensin III是血管紧张素1 (AT1) 和 AT2 受体激动剂。

  • GC35356 structure
    GC35356Angiotensin III TFA
    纯度: >99.50%

    Angiotensin III (TFA) 是血管紧张素1 (AT1) 和 AT2 受体激动剂。

  • GC35361 structure
    GC35361Antineoplaston A10
    CAS: 91531-30-5
    纯度: >98.00%

    Antineoplaston A10 is a naturally occurring substance in the human body that that can be potentially used for the treatment of glioma, lymphoma, astrocytoma and breast cancer. The main ingredient active of antineoplaston A10 (Phenylacetylglutamine, PG) inhibits RAS and promotes apoptosis.

  • GC35367 structure
    GC35367APG-115
    CAS: 1818393-16-6
    纯度: >98.00%

    APG-115 (APG-115) 是一种具有口服活性的 MDM2 蛋白抑制剂，与 MDM2 蛋白结合，IC50 和 Ki 值分别为 3.8 nM 和 1 nM。 APG-115 阻断 MDM2 和 p53 的相互作用，并以 p53 依赖性方式诱导细胞周期停滞和细胞凋亡。

  • GC35369 structure
    GC35369Apigenin-7-glucuronide
    CAS: 29741-09-1
    纯度: >98.50%

    Apigenin-7-O-glucuronide (Apigenin-7-glucuronide) is the major flavonoid found in milk thistle. Apigenin 7-o-glucuronide inhibits tumor necrosis factor alpha (TNF-α) and total nitrite release in lipopolysaccharide-activated macrophages.

  • GC35377 structure
    GC35377Apratastat
    CAS: 287405-51-0
    纯度: >99.00%

    Apratastat是一种口服活性、可逆的双重抑制剂，能够抑制肿瘤坏死因子-α转换酶（TACE；IC 50 =81.7ng/mL）和基质金属蛋白酶（MMPs）的活性。

  • GC35379 structure
    GC35379Arachidic acid
    CAS: 506-30-9
    纯度: >99.00%

    A long- chain saturated fatty acid

  • GC35384 structure
    GC35384Argatroban monohydrate
    CAS: 141396-28-3
    纯度: >99.50%

    A thrombin inhibitor

  • GC35388 structure
    GC35388Aristolactam I
    CAS: 13395-02-3
    纯度: >99.50%

    Aristololactam I (AL-I) 是马兜铃酸I (AA-I) 的主要代谢产物，参与导致肾损伤的过程。Aristololactam I (AL-I) 直接损伤肾近端小管细胞，AL-I 的细胞毒性效力高于AA-I，并且这些分子的细胞毒性作用是通过 caspase-3 依赖性细胞凋亡介导。

  • GC35395 structure
    GC35395Arnicolide D
    CAS: 34532-68-8
    纯度: >98.00%

    A sesquiterpene lactone with anticancer activity

  • GC35420 structure
    GC35420ATP
    CAS: 56-65-5
    纯度: >99.50% / >99.00% / >98.00%

    ATP是代谢反应中底物激活的磷酸基供体，用于生物合成细胞内第二信使环状腺苷酸单磷酸（cAMP），并作为真正的细胞外信使介导细胞间通讯。

  • GC35425 structure
    GC35425Atreleuton
    CAS: 154355-76-7

    A 5-LO inhibitor

  • GC35470 structure
    GC35470Batimastat sodium salt
    CAS: 130464-84-5

    A potent broad spectrum inhibitor of MMPs

  • GC35476 structure
    GC35476BAY-678 racemate
    CAS: 675103-35-2

    BAY-678 racemate 是 BAY-678 的消旋体。BAY-678 是具有口服生物活性的、高效的、选择性的、人中性粒细胞弹性蛋白酶(HNE) 的细胞渗透性抑制剂，其 IC50 值为 20 nM。BAY-678 也是被基因结构组学联盟 (SGC) 推荐的化学探针。

  • GC35494 structure
    GC35494Benzoyloxypaeoniflorin
    CAS: 72896-40-3

    Benzoyloxypaeoniflorin 分离于 Paeonia suffruticosa 的根，是 tyrosinase 抑制剂，对蘑菇 tyrosinase 的 IC50为 0.453 mM。Benzoyloxypaeoniflorin 是 NF-κB 抑制剂，Benzoyloxypaeoniflorin 通过对血小板聚集和凝血的抑制作用，有助于改善血液循环。

  • GC35499 structure
    GC35499Bestatin trifluoroacetate
    CAS: 223763-80-2

    An aminopeptidase inhibitor

  • GC35510 structure
    GC35510BI 224436
    CAS: 1155419-89-8
    纯度: >99.50%

    BI 224436是一种新型的HIV-1非催化性位点整合酶抑制剂，对HIV-1实验室菌株的EC50值小于15 nM。

  • GC35511 structure
    GC35511BI-0252
    CAS: 1818291-27-8

    BI-0252 是一种具有口服活性，选择性的 MDM2-p53 抑制剂，IC50 值为 4 nM。 BI-0252 可诱导异种移植小鼠 SJSA-1 的所有动物肿瘤消退，同时诱导肿瘤蛋白p53 (TP53) 靶基因和凋亡标志物。