GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC35521 structure
    GC35521Biotin sulfone
    CAS: 40720-05-6

    An oxidized form of biotin

  • GC35528 structure
    GC35528Bivalirudin TFA
    CAS: 1191386-55-6
    纯度: >99.50%

    A thrombin inhibitor

  • GC35535 structure
    GC35535BMS-906024
    CAS: 1401066-79-2
    纯度: >98.00%

    BMS-906024 是一种口服有效，选择性的 γ 分泌酶 (gamma secretase) 抑制剂 (GSI)，GSIs 是一类小分子 Notch 抑制剂。BMS-906024 可阻止具有高口服生物利用度的所有四种 Notch 受体的激活，对于 Notch1，-2，-3 和 -4 受体，IC50s 分别为 1.6，0.7，3.4 和 2.9 nM。 BMS-906024 表现出针对多种人癌症异种移植物的广谱抗肿瘤活性。

  • GC35541 structure
    GC35541Boldenone Undecylenate
    CAS: 13103-34-9

    An Analytical Reference Standard

  • GC35608 structure
    GC35608Carboxypeptidase G2 (CPG2) Inhibitor
    CAS: 192203-60-4
    纯度: >98.00%

    Carboxypeptidase G2 (CPG2) Inhibitor是羧肽酶G2（CPG2）抑制剂，具有抗癌活性。

  • GC35625 structure
    GC35625CC0651
    CAS: 1319207-44-7
    纯度: >99.50%

    CC0651 是一种人Cdc34泛素结合酶变构抑制剂。CC0651 有效抑制 p27Kip1的泛素化，IC50 为 1.72 μM。

  • GC35675 structure
    GC35675Chimonanthine
    CAS: 5545-89-1

    Chimonanthine 是腊梅中的生物碱，抑制酪氨酸酶及酪氨酸酶相关蛋白 1 mRNA 的表达，抑制黑色素的形成。

  • GC35703 structure
    GC35703Citicoline
    CAS: 987-78-0
    纯度: >99.50%

    An intermediate in the synthesis of phosphatidylcholine

  • GC35740 structure
    GC35740CP-640186 hydrochloride
    CAS: 591778-70-0
    纯度: >99.50%

    An ACC inhibitor

  • GC35741 structure
    GC35741CPA inhibitor
    CAS: 223532-02-3
    纯度: >99.50%

    CPA inhibitor是羧肽酶A（CPA）抑制剂。

  • GC35752 structure
    GC35752CS-722 Free base
    CAS: 749179-13-3

    CS-722 Free base 是一种合成的中枢作用肌肉松弛剂，具有肌肉松弛活性和对脊髓反射的抑制作用。CS-722 Free base 可能通过抑制钠和钙电流来抑制海马培养物中的自发抑制性突触后电流和兴奋性突触后电流。

  • GC35754 structure
    GC35754CTTHWGFTLC, CYCLIC
    CAS: 244082-19-7

    CTTHWGFTLC, CYCLIC 是基质金属蛋白酶 MMP-2 和 MMP-9 的环肽抑制剂。

  • GC35757 structure
    GC35757Cucurbitacin D
    CAS: 3877-86-9
    纯度: >98.00%

    A triterpenoid with diverse biological activities

  • GC35780 structure
    GC35780Cycloguanil
    CAS: 516-21-2

    Cycloguanil hydrochloride, an active metabolite of proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.

  • GC35793 structure
    GC35793D-(+)-Phenyllactic acid
    CAS: 7326-19-4
    纯度: >99.50%

    D-3-Phenyllactic acid is a chiral building block that is used in preparation of statine.

  • GC35794 structure
    GC35794D-(-)-Lactic acid
    CAS: 10326-41-7
    纯度: >90.00%

    D-(-)-Lactic acid 是糖发酵 (氧化，新成代谢) 的一个中间产物。D-(-)-Lactic acid 在植物中是 ProDH (proline dehydrogenase 1)) 的竞争性抑制剂。

  • GC35802 structure
    GC35802Dabigatran ethyl ester hydrochloride
    CAS: 211914-50-0
    纯度: >99.00%

    Dabigatran ethyl ester hydrochloride是有效地核糖基二氢烟酰胺脱氢酶(NQO2)抑制剂，IC50值为0.8 μM；也是凝血酶的抑制剂。

  • GC35819 structure
    GC35819D-chiro-Inositol
    CAS: 643-12-9
    纯度: >98.00%

    D-chiro-Inositol 是一种肌醇差向异构体，存在于某些哺乳动物糖基磷脂酰肌醇蛋白锚和具有胰岛素样生物活性的肌醇磷脂聚糖中。D-chiro-Inositol 用于治疗多囊卵巢综合征 (PCOS) 和糖尿病。D-chiro-Inositol 可降低高血糖，改善胰岛素抵抗。

  • GC35850 structure
    GC35850DGAT-1 inhibitor 2
    CAS: 942999-61-3
    纯度: >98% / >95%

    DGAT-1 inhibitor 2是有效的DGAT-1抑制剂，具有减肥功效。

  • GC35851 structure
    GC35851DGAT1-IN-1
    CAS: 1449779-49-0

    DGAT1-IN-1是高效DGAT1抑制剂，IC50值低于10nM（Hep3B细胞过表达DGAT1裂解物测得）。

  • GC35852 structure
    GC35852D-Glucose 6-Phosphate~1 M in H2O(260 mg/ml)
    CAS: 56-73-5
    纯度: >98.00%

    D-Glucose 6-Phosphate是葡萄糖经过磷酸化(在第6号碳的羟基上)生成的葡萄糖。

  • GC35861 structure
    GC35861Dichlorisone acetate
    CAS: 79-61-8
    纯度: >99.50%

    Dichlorisone acetate是用作抗炎剂的合成糖皮质激素皮质类固醇。

  • GC35863 structure
    GC35863Diethyl oxalpropionate
    CAS: 759-65-9
    纯度: >95.00%

    Methyloxalacetic acid diethyl ester (Diethyl 2-methyl-3-oxosuccinate, Diethyl methyloxobutanedioate, Diethyl oxalpropionate) is a member of the class of compounds known as beta-keto acids and derivatives.

  • GC35865 structure
    GC35865Dihydroxyacetone phosphate
    CAS: 57-04-5

    A glycerolipid precursor