Cucurbitacin D is a triterpenoid that has been found in Cucurbita texana and has diverse biological activities.1,2,3 It decreases levels of the heat shock protein 90 (Hsp90) client proteins HER2, Raf, and cyclin-dependent kinase 6 (Cdk6) in MCF-7 breast cancer cell lysates in a concentration-dependent manner and inhibits the proliferation of MCF-7 cells (IC50 = 0.598 ?M).1 Cucurbitacin D (0.1 ?M) inhibits cigarette smoke condensate-induced HIV-1 replication in chronically HIV-1-infected U1 macrophages.2 In vivo, cucurbitacin D (0.025 mg/kg) decreases cold and mechanical allodynia in a mouse model of neuropathic pain induced by paclitaxel .3
1.Hall, J.A., Seedarala, S., Rice, N., et al.Cucurbitacin D Is a disruptor of the HSP90 chaperone machineryJ. Nat. Prod.78(4)873-879(2015) 2.Kodidela, S., Sinha, N., Kumar, A., et al.Anti-HIV activity of cucurbitacin-D against cigarette smoke condensate-induced HIV replication in the U1 macrophagesViruses13(6)1004(2021) 3.Lee, J.H., Kim, B., Ko, S.-G., et al.Analgesic effect of SH003 and Trichosanthes kirilowii Maximowicz in paclitaxel-induced neuropathic pain in miceCurr. Issues Mol. Biol.44(2)718-730(2022)