GlpBio

HSP

HSP(热休克蛋白)

Heat shock proteins (HSPs) are a family of highly conserved proteins that are expressed, either constitutively or regulated inductively, in response to a wide range of physiological and environmental insults, such as heat shock. According to molecular weight, mammalian HSPs are classified into four subfamilies, including HSP90 (90 kDa), HSP70 (70 kDa), HSP60 (60 kDa) and small HSPs (15 to 30 kDa), among which HSP90 and HSP70 are two of the most studied stress-inducible HSPs. HSP90 is a highly abundant chaperone protein characterized by containing three relevant domains, including the N-terminal domain, the charged middle linker region and the C-terminal dimerization domain; while HSP70 is an ATP-dependent chaperone protein characterized by containing two distinct functional domains, including a peptide binding domain (PBD) and the amino-terminal ATPase domain (ABD). Collectively HSPs play a fundamental role in maintaining the stability of other cellular proteins.

HSP 相关产品(97)

  • GC10327 structure
    GC10327Retaspimycin
    CAS: 857402-23-4

    Retaspimycin 是一种有效的 Hsp90 抑制剂，对 Hsp90 和 Grp9 的 EC50 均为 119 nM。

  • GC11179 structure
    GC11179NVP-BEP800
    CAS: 847559-80-2
    纯度: >99.50%

    An Hsp90 inhibitor

  • GC11391 structure
    GC11391IPI-504 (Retaspimycin hydrochloride)
    CAS: 857402-63-2
    纯度: >98.00%

    IPI-504 (Retaspimycin hydrochloride) 是一种有效的 Hsp90 抑制剂，对 Hsp90 和 Grp9 的 EC50 均为 119 nM。

  • GC11912 structure
    GC11912PF-04929113 (SNX-5422)
    CAS: 908115-27-5

    A prodrug for an Hsp90 inhibitor

  • GC12218 structure
    GC12218BIIB021
    CAS: 848695-25-0
    纯度: >99.50%

    A potent, orally-available Hsp90 inhibitor

  • GC13044 structure
    GC1304417-DMAG (Alvespimycin) HCl
    CAS: 467214-21-7
    纯度: >98.00%

    17-DMAG (Alvespimycin) HCl是一种有效的Hsp90的抑制剂，其IC 50 值为62nM。

  • GC13414 structure
    GC13414AT13387
    CAS: 912999-49-6
    纯度: >99.50%

    AT13387是一种小分子非安沙霉素类HSP90（热休克蛋白90）抑制剂，其作用机制是通过靶向AKT和ERK信号通路。

  • GC13946 structure
    GC13946SNX-2112
    CAS: 908112-43-6

    SNX-2112是一种强效的合成型热休克蛋白（Hsp 90）抑制剂，IC 50 值为30nM。

  • GC14636 structure
    GC14636KW-2478
    CAS: 819812-04-9
    纯度: >98.50%

    An Hsp90 inhibitor

  • GC15295 structure
    GC15295AUY922 (NVP-AUY922)
    CAS: 747412-49-3
    纯度: >99.50% / >98.00%

    AUY922 (NVP-AUY922)是一种高效且选择性的 HSP90抑制剂，对 HSP90α和 HSP90β的 IC 50 值分别为 13nM和 21nM。

  • GC16361 structure
    GC16361Geldanamycin
    CAS: 30562-34-6
    纯度: >99.50%

    Binds Hsp90 and GRP94, inhibits growth of cancer cells

  • GC10223 structure
    GC10223CCT018159
    CAS: 171009-07-7
    纯度: >98.50%

    An Hsp90 inhibitor

  • GC10481 structure
    GC10481TRC 051384
    CAS: 867164-40-7
    纯度: >98.00%

    TRC 051384 是一种热休克蛋白 70 (HSP70) 诱导剂。

  • GC11065 structure
    GC11065Pifithrin-μ
    CAS: 64984-31-2
    纯度: >98.00%

    Pifithrin-μ是p53和HSP70的抑制剂。

  • GC11669 structure
    GC11669Tamoxifen Citrate
    CAS: 54965-24-1
    纯度: >99.50%

    A selective estrogen receptor modulator

  • GC11720 structure
    GC1172017-AAG (KOS953)
    CAS: 75747-14-7
    纯度: >99.00% / >98.00%

    17-AAG（格尔德霉素）是一种天然的苯醌安沙霉素抗生素，是第一个确定的 Hsp90 抑制剂。

  • GC11930 structure
    GC11930KNK437
    CAS: 218924-25-5
    纯度: >98.00%

    Prevents the synthesis of inducible heat shock proteins

  • GC11973 structure
    GC11973HSP990 (NVP-HSP990)
    CAS: 934343-74-5
    纯度: >98.00%

    An Hsp90 inhibitor

  • GC12301 structure
    GC12301Mizoribine
    CAS: 50924-49-7
    纯度: >98.50%

    An imidazole nucleoside with immunosuppressive properties

  • GC13307 structure
    GC13307PU-WS13
    CAS: 1454619-14-7
    纯度: >98.00%

    PU-WS13是一种嘌呤支架类Grp94特异性热休克蛋白90（Hsp90）抑制剂。

  • GC13885 structure
    GC13885Elesclomol (STA-4783)
    CAS: 488832-69-5
    纯度: >99.00% / >98.00%

    Elesclomol（也称为 STA-4783）最初是在基于细胞的表型筛选中发现的促凋亡活性，是一种新型小分子，可通过快速产生活性氧 (ROS) 有效诱导癌细胞凋亡以及难以控制的氧化应激水平的诱导。

  • GC14411 structure
    GC14411Apoptozole
    CAS: 1054543-47-3
    纯度: >99.50%

    Apoptozole是一种小分子抑制剂，可靶向HSC70和HSP72，K D 值分别为210nM和140nM。

  • GC16892 structure
    GC16892XL-888
    CAS: 1149705-71-4
    纯度: >99.50%

    An orally bioavailable Hsp90 inhibitor

  • GC16966 structure
    GC16966VER 155008
    CAS: 1134156-31-2
    纯度: >99.50%

    VER 155008是一种强效的，源自腺苷的热休克蛋白70（Hsp70）家族抑制剂，对Hsp70、热休克同源蛋白70（Hsc70）和葡萄糖调节蛋白78（Grp78）的IC 50 值分别为0.5μM、2.6μM和2.6μM。