HSP
HSP(热休克蛋白)
Heat shock proteins (HSPs) are a family of highly conserved proteins that are expressed, either constitutively or regulated inductively, in response to a wide range of physiological and environmental insults, such as heat shock. According to molecular weight, mammalian HSPs are classified into four subfamilies, including HSP90 (90 kDa), HSP70 (70 kDa), HSP60 (60 kDa) and small HSPs (15 to 30 kDa), among which HSP90 and HSP70 are two of the most studied stress-inducible HSPs. HSP90 is a highly abundant chaperone protein characterized by containing three relevant domains, including the N-terminal domain, the charged middle linker region and the C-terminal dimerization domain; while HSP70 is an ATP-dependent chaperone protein characterized by containing two distinct functional domains, including a peptide binding domain (PBD) and the amino-terminal ATPase domain (ABD). Collectively HSPs play a fundamental role in maintaining the stability of other cellular proteins.
HSP 相关产品(97)
- GC17655Ganetespib (STA-9090)CAS: 888216-25-9纯度: >99.50%
Ganetespib (STA-9090) (STA-9090) 是一种热休克蛋白 90 (HSP90) 抑制剂，在多种血液和实体肿瘤细胞系中表现出强效细胞毒性。 Ganetespib (STA-9090) 通过抑制 HIF-1α 在结直肠癌中具有抗血管生成作用；和 STAT3。
- GC32869HSP70-IN-1CAS: 1268273-90-0纯度: >98.00%
HSP70-IN-1是一种热休克蛋白(HSP)抑制剂;抑制Kasumi-1细胞的生长的IC50值为2.3μM。
- GC33426Rocaglamide (Rocaglamide A)CAS: 84573-16-0纯度: >98.50%
Rocaglamide (Rocaglamide A) 是从 Aglaia 属（楝科）中分离出来的。
- GC34634JG-98CAS: 1456551-16-8纯度: >98.00%
JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC17210 | 17-AAG Hydrochloride | 911710-03-7 | - | |
Hsp90 inhibitor,geldanamycin analogue | ||||
| GC17655 | Ganetespib (STA-9090) | 888216-25-9 | >99.50% | |
Ganetespib (STA-9090) (STA-9090) 是一种热休克蛋白 90 (HSP90) 抑制剂，在多种血液和实体肿瘤细胞系中表现出强效细胞毒性。 Ganetespib (STA-9090) 通过抑制 HIF-1α 在结直肠癌中具有抗血管生成作用；和 STAT3。 | ||||
| GC17751 | MKT 077 | 147366-41-4 | >98.00% | |
An Hsp70 inhibitor | ||||
| GC17901 | Tamoxifen | 10540-29-1 | >98.00% / >99.00% | |
Tamoxifen(他莫西芬)是一种选择性雌激素受体调节剂 (SERM),可阻断乳腺细胞中的雌激素作用,并可激活不同组织细胞中的雌激素活性;Tamoxifen 还可以作为 Hsp90 激活剂,增强 Hsp90 分子伴侣 ATPase 的活性;Tamoxifen 还可以诱导 CreER(T2) 小鼠的基因敲除。 | ||||
| GC18170 | ML-346 | 100872-83-1 | >98.00% | |
An activator of the heat shock response | ||||
| GC18832 | Conglobatin | 72263-05-9 | - | |
An Hsp90 inhibitor | ||||
| GC19094 | CCT251236 | 1693731-40-6 | >99.00% | |
An inhibitor of Hsf1-mediated transcription | ||||
| GC19121 | Debio 0932 | 1061318-81-7 | >98.00% | |
An Hsp90 inhibitor | ||||
| GC19188 | HA15 | 1609402-14-3 | >99.50% | |
HA15是一种特异性靶向BiP/GRP78/HSPA5的分子，可结合并抑制其ATPase活性，导致BiP与PERK、IRE1α和ATF6分离，从而引发内质网应激。 | ||||
| GC19215 | KRIBB11 | 342639-96-7 | >98.00% | |
An Hsf1 inhibitor | ||||
| GC31103 | Arimoclomol maleate (BRX-220) | 289893-26-1 | >99.50% | |
A co-inducer of heat shock proteins | ||||
| GC31118 | KU-32 | 956498-70-7 | - | |
KU-32是一种新型的，基于新生霉素的Hsp90抑制剂，可以预防神经细胞死亡。 | ||||
| GC32008 | Feretoside | 27530-67-2 | - | |
Feretoside是一种从杜仲树皮中提取的酚类化合物。它是HSP诱导剂，可作为细胞保护剂。 | ||||
| GC32437 | HSF1A | 1196723-93-9 | >99.00% | |
HSF1A是热休克转录因子1（HSF1）的激活剂。 | ||||
| GC32620 | Bimoclomol | 130493-03-7 | >99.00% | |
Bimoclomol是一种heatshockprotein(HSP)辅诱导剂，可用于心血管疾病的研究。 | ||||
| GC32869 | HSP70-IN-1 | 1268273-90-0 | >98.00% | |
HSP70-IN-1是一种热休克蛋白(HSP)抑制剂;抑制Kasumi-1细胞的生长的IC50值为2.3μM。 | ||||
| GC32965 | Ethoxyquin | 91-53-2 | >98.00% | |
An antioxidant used in animal feed | ||||
| GC33047 | SNX-5422 Mesylate (PF-04929113 (Mesylate)) | 1173111-67-5 | - | |
A prodrug for an Hsp90 inhibitor | ||||
| GC33286 | TAS-116 | 1260533-36-5 | >99.00% | |
An Hsp90 inhibitor | ||||
| GC33426 | Rocaglamide (Rocaglamide A) | 84573-16-0 | >98.50% | |
Rocaglamide (Rocaglamide A) 是从 Aglaia 属（楝科）中分离出来的。 | ||||
| GC33663 | Teprenone (Geranylgeranylacetone) | 6809-52-5 | >99.50% | |
An inducer of Hsp expression | ||||
| GC34539 | Col003 | 328565-16-8 | >95.00% | |
Col003是一种有效的Hsp47抑制剂，竞争性地与Hsp47上的胶原结蛋白合位点结合(IC50，1.8μM)，通过破坏胶原蛋白的三重螺旋结构抑制胶原蛋白的分泌。 | ||||
| GC34634 | JG-98 | 1456551-16-8 | >98.00% | |
JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity. | ||||
| GC35757 | Cucurbitacin D | 3877-86-9 | >98.00% | |
A triterpenoid with diverse biological activities | ||||