Zilpaterol-d7 is intended for use as an internal standard for the quantification of zilpaterol by GC- or LC-MS. Zilpaterol is a β-adrenergic receptor agonist that putatively, through activation of protein kinase A, increases protein synthesis in skeletal muscle fibers as well as reduces lipogenesis and increases lipolysis in adipose tissues.1,2 Formulations containing zilpaterol have been used to increase lean body weight and improve feed efficiency in commercial beef cattle.3
1.AvendaÑo-Reyes, L., Torres-RodrÍguez, V., Meraz-Murullo, F.J., et al.Effects of two β-adrenergic agonists on finishing performance, carcass characteristics, and meat quality of feedlot steersJ. Anim. Sci.84(12)3259-3265(2006) 2.Miller, E.K., Chung, K.Y., Hutcheson, J.P., et al.Zilpaterol hydrochloride alters abundance of β-adrenergic receptors in bovine muscle cells but has little effect on de novo fatty acid biosynthesis in bovine subcutaneous adipose tissue explantsJ. Anim. Sci.90(4)1317-1327(2012) 3.Delmore, R.J., Hodgen, J.M., and Johnson, B.J.Perspectives on the application of zilpaterol hydrochloride in the United States beef industryJ. Anim. Sci.88(8)2825-2828(2010)