GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC35866 structure
    GC35866Dimethyl trisulfide
    CAS: 3658-80-8
    纯度: >98.00%

    Dimethyl trisulfide (Methyl trisulfide, DMTS, 2,3,4-trithiapentane) is an organic chemical compound and the simplest organic trisulfide.

  • GC35877 structure
    GC35877DL-Homocystine
    CAS: 870-93-9

    An oxidized dimeric form of homocysteine

  • GC35884 structure
    GC35884DMP 777
    CAS: 157341-41-8
    纯度: >98.50%

    DMP 777 是一种有效的，选择性的，可口服的 human leukocyte elastase (HLE) 抑制剂。

  • GC35908 structure
    GC35908Duocarmycin A
    CAS: 118292-34-5

    Duocarmycin A 是众所周知的抗肿瘤抗生素之一，可有效地使 DNA 中富含 AT 的序列 3' 末端的腺嘌呤 N3 烷基化。Duocarmycin A 作为一种化学治疗剂，通常导致 HLC-2 细胞凋亡，包括染色质浓缩，DNA 直方图模式中的亚 G1 积累，以及procaspase-3 和 9 水平的降低。

  • GC35921 structure
    GC35921E 2012
    CAS: 870843-42-8

    A γ-secretase modulator

  • GC35980 structure
    GC35980Emricasan
    CAS: 254750-02-2
    纯度: >99.50% / >98.00% / >98.50%

    Emricasan是一种口服有效、不可逆的广谱胱天蛋白酶抑制剂，具有良好的药代动力学特征。

  • GC35983 structure
    GC35983Enalaprilat D5
    CAS: 349554-00-3

    Enalaprilat D5是Enalaprilat的氘代化合物标准品。

  • GC35984 structure
    GC35984Enalaprilat D5 Sodium Salt
    CAS: 1356922-29-6
    纯度: >98.00%

    依那普利拉 (MK-422) D5 钠盐是氘标记的依那普利拉 (MK-422)，它是一种血管紧张素转换酶 (ACE) 抑制剂。

  • GC35990 structure
    GC35990Endoxifen hydrochloride
    CAS: 1197194-41-4
    纯度: >98.00%

    Endoxifen hydrochloride 是 Tamoxifen 的活性代谢物，是有效的雌激素受体 (estrogen receptor) 拮抗剂。

  • GC36036 structure
    GC36036Febuxostat D9
    CAS: 1246819-50-0

    An internal standard for the quantification of febuxostat

  • GC36038 structure
    GC36038FGTI-2734
    CAS: 1247018-19-4
    纯度: >99.00%

    FGTI-2734 是 RAS C-末端法尼基转移酶 (FT) 和香叶烯基转移酶-1 (GGT) 抑制剂，对 FT 和 GGT 的 IC50s 分别为 250 nM和 520 nM。 FGTI-2734 可以阻断 KRAS 的膜定位，从而解决 KRAS 耐药性问题，并抑制突变的 KRAS 胰腺肿瘤。

  • GC36058 structure
    GC36058Flumazenil acid
    CAS: 84378-44-9

    Flumazenil acid 是 Flumazenil 的一种代谢产物。Flumazenil 是一种 GABAA 受体拮抗剂。

  • GC36086 structure
    GC36086FTI-277
    CAS: 170006-73-2

    FTI 277 HCl is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. FTI 277 HCl inhibits cell growth and induces apoptosis. FTI 277 HCl is effective in clearing HDV viremia.

  • GC36107 structure
    GC36107gamma-secretase modulator 1
    CAS: 1172637-87-4
    纯度: >98.00%

    γ-secretase inhibitior-1是γ-secretase调节剂，可作用于阿尔茨海默病。

  • GC36108 structure
    GC36108gamma-secretase modulator 2
    CAS: 1093978-89-2
    纯度: >98.50%

    Gamma-secretase modulator 2是γ-secretase调节剂，可用于阿尔兹海默。

  • GC36109 structure
    GC36109gamma-secretase modulator 3
    CAS: 1431697-84-5
    纯度: >99.00%

    gamma-secretase modulator 3是γ-secretase调节剂。

  • GC36116 structure
    GC36116Ganoderic acid B
    CAS: 81907-61-1
    纯度: >98.00%

    A triterpenoid with diverse biological activities

  • GC36120 structure
    GC36120Ganodermanondiol
    CAS: 107900-76-5

    Ganodermanondiol 是从灵芝中分离出的一种促黑素生成抑制剂。Ganodermanondiol 对叔丁基过氧化氢诱导的肝毒性具有高效的细胞保护作用。Ganodermanondiol 具有抗 HIV-1 protease 活性，其 IC50 值为 90 μM。Ganodermanondiol 具有很强的抗补体活性，对经典补体途径作用的 IC50 值为 41.7 μM。

  • GC36132 structure
    GC36132Genistein 8-c-glucoside
    CAS: 66026-80-0
    纯度: >99.00%

    Genistein 8-c-glucoside (G8CG) 是从 Lupinus luteus L 花中分离的一种天然葡萄糖苷。Genistein 8-c-glucoside 诱导线粒体膜去极化并诱导细胞凋亡 (apoptosis)。

  • GC36137 structure
    GC36137Ginsenoside F4
    CAS: 181225-33-2

    Ginsenoside F4 (GF4)，人参皂甙，从三七或红参中分离。Ginsenoside F4 (GF4) 通过诱导凋亡 (apoptosis) 对人淋巴细胞瘤 JK 细胞具有抑制作用。Ginsenoside F4 (GF4) 抑制 IL-1β 处理的软骨细胞中基质金属蛋白酶 13 (MMP 13) 的表达，阻断兔软骨组织培养中的软骨损坏，具有防止病变组织的软骨胶原基质分解的治疗潜力。

  • GC36144 structure
    GC36144Glabrene
    CAS: 60008-03-9

    Glabrene 是一种来源于甘草根的异黄酮，具有雌激素样活性。Glabrene 是 tyrosinase 抑制剂，IC50 值为 3.5 μM。

  • GC36151 structure
    GC36151Glucagon-Like Peptide (GLP) II, human
    CAS: 89750-15-2

    Glucagon-Like Peptide (GLP) II, human 是由原胰高血糖素 C 端衍生的33 氨基酸肽，主要由肠道L细胞产生。Glucagon-Like Peptide (GLP) II 可刺激肠粘膜生长，减少肠细胞的凋亡。

  • GC36158 structure
    GC36158Glycerol
    CAS: 56-81-5
    纯度: >99.00% / >99.50% / 100%

    Glycerol (Glycerin) is a clear, colourless and viscous liquid that can be used as emollient, solvent or sweetening agent. Glycerol changes the separation characteristics of polyacrylamide nucleoprotein gels.

  • GC36159 structure
    GC36159Glycerol 3-phosphate
    CAS: 17989-41-2
    纯度: >98.00% / >95.00% / >99.00%

    Glycerol 3-phosphate是由细胞溶质甘油3-磷酸脱氢酶途径产生的，胞质甘油3-磷酸脱氢酶（GPDH）消耗NADH从磷酸二羟基丙酮（DHAP）产生Glycerol 3-phosphate，生成的Glycerol 3-phosphate可穿过可渗透的线粒体外膜。Glycerol 3-phosphate为游离形式化合物不稳定，推荐具有相同生物学活性的稳定盐形式sn-Glycerol 3-phosphate lithium（GC61482）。