GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC36230 structure
    GC36230Histatin 5 (TFA)

    Histatin 5 TFA 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 活性，IC50s 分别为 0.57 和 0.25 μM。

  • GC36233 structure
    GC36233HIV-1 integrase inhibitor 2
    CAS: 957890-42-5
    纯度: >99.00%

    HIV-1 整合酶抑制剂 2 (CX05168) 是一种基于喹啉的 LEDGF/p75 和 HIV 整合酶的蛋白-蛋白相互作用抑制剂。

  • GC36234 structure
    GC36234HIV-1 integrase inhibitor 3
    CAS: 1638504-56-9

    HIV-1 integrase inhibitor 3 是一种 HIV-1 整合酶链转移 (INST) 抑制剂，其 IC50 值为 2.7 nM。

  • GC36235 structure
    GC36235HIV-1 integrase inhibitor 4
    CAS: 1638504-66-1

    HIV-1 integrase inhibitor 4 是一种 HIV-1 整合酶链转移 (INST) 抑制剂，其 IC50 值为 3.7 nM。

  • GC36292 structure
    GC36292IDH1 Inhibitor 2
    CAS: 2244895-42-7

    IDH1 Inhibitor 2 是有效的IDH1 抑制剂，通过对 His315的共价修饰发挥作用，其IC50 值为110 nM。

  • GC36293 structure
    GC36293IDH1 Inhibitor 3
    CAS: 2171081-24-4

    IDH1 Inhibitor 3 (compound 6f) 是突变型的 IDH1 的抑制剂，其对IDH1R132H 的 IC50 值为 45 nM。

  • GC36304 structure
    GC36304IMR-1A
    CAS: 331862-41-0
    纯度: >98.00%

    IMR-1A, an acid metabolite of IMR-1, is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. IMR-1A exhibits anti-tumor activity.

  • GC36309 structure
    GC36309Indinavir
    CAS: 150378-17-9

    Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.

  • GC36310 structure
    GC36310Indinavir sulfate
    CAS: 157810-81-6
    纯度: >99.50%

    An HIV- 1 protease inhibitor

  • GC36333 structure
    GC36333Isoescin IA
    CAS: 219944-39-5
    纯度: >98.50%

    Isoescin IA 是一种从 Aesculus chinensis 种子中分离出的三萜皂苷。Isoescin IA 具有抗 HIV-1 蛋白酶活性。

  • GC36368 structure
    GC36368JHU-083
    CAS: 1998725-11-3
    纯度: >98.00%

    JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.Solutions are best fresh-prepared.

  • GC36402 structure
    GC36402Kushenol A
    CAS: 99217-63-7
    纯度: >99.50%

    Kushenol A 是从苦参 (Sophora flavescent) 的根中分离出来的，一种非竞争性酪氨酸酶 (tyrosinase) 抑制剂，IC50 和 Ki 值分别为 1.1 μM 和 0.4 μM。Kushenol A 是一种黄酮类抗氧化剂，对 α-葡萄糖苷酶 (alpha-glucosidase) 和 β-淀粉酶(beta-amylase)具有抑制作用。Kushenol A 被证实是可用于化妆品的针对皮肤美白和衰老的潜在物质。

  • GC36412 structure
    GC36412L-Leucyl-L-alanine
    CAS: 7298-84-2

    L-Leucyl-L-alanine Hydrate (H-Leu-Ala-OH) is a dipeptide composed of L-leucine and L-alanine joined by a peptide linkage. It is a metabolite.

  • GC36416 structure
    GC36416L-5-Hydroxytryptophan
    CAS: 4350-09-8
    纯度: >99.50% / >99.00%

    An intermediate in serotonin biosynthesis

  • GC36419 structure
    GC36419Lactose
    CAS: 63-42-3
    纯度: >98.00%

    Lactose is a disaccharide naturally found in milk and dairy.

  • GC36431 structure
    GC36431L-Cysteine hydrochloride
    CAS: 52-89-1
    纯度: >99.00%

    A conditionally essential amino acid

  • GC36432 structure
    GC36432LDN-0088050
    CAS: 353484-30-7

    LDN 0088050 是一种选择性的脂肪酸结合蛋白 (AFABP, FABP4) 抑制剂，FABP4、FABP3 的 Ki 值分别为 0.29、1.3 μM. LDN 0088050 结合 FABP4 的Kd 值为 2.05 μM。

  • GC36443 structure
    GC36443Levomefolic acid
    CAS: 31690-09-2
    纯度: >98.50%

    Levomefolic acid是一种具有口服活性且可通过血脑屏障的叶酸生物活性形式。

  • GC36456 structure
    GC36456Licoricidin
    CAS: 30508-27-1

    Licoricidin (LCD) 从甘草 Glycyrrhiza uralensis Fisch 中分离，具有抗癌活性。Licoricidin (LCD) 通过诱导周期停滞，诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)，是一种对抗结直肠癌的潜在化学预防或化学治疗剂。Licoricidin (LCD) 通过抑制肿瘤血管生成和淋巴管生成以及肿瘤组织局部微环境的变化抑制肺转移。Licoricidin (LCD) 通过体外和体内 Akt 和 NF-κB 途径的失活，增强吉西他滨诱导的骨肉瘤 (OS) 细胞的细胞毒性。Licoricidin (LCD) 通过 ROS 清除阻断 UVA 诱导的光老化，限制 MMP-1 的活性，被认为是新的局部应用的抗衰老制剂中的活性成分。

  • GC36465 structure
    GC36465Liothyronine
    CAS: 6893-02-3
    纯度: >98.00%

    An thyroid hormone which binds to TRβ1, and activates its activity

  • GC36469 structure
    GC36469L-Lactic acid
    CAS: 79-33-4
    纯度: >98.00%

    L-Lactic acid is a natural product that is used as a food additive.

  • GC36470 structure
    GC36470L-Lysine
    CAS: 56-87-1

    Lysine is an α-amino acid that is used in the biosynthesis of proteins and is required for growth and tissue repair.

  • GC36489 structure
    GC36489Lucidenic acid C
    CAS: 95311-96-9

    Lucidenic acid C 是从灵芝中分离得到的天然产物，可抑制 PMA 诱导的 MMP-9 活性，对肝癌细胞具有抗侵袭作用。

  • GC36491 structure
    GC36491Lucideric acid A
    CAS: 95311-94-7

    A triterpene with anticancer activity