Ganoderic acid B is a triterpenoid that has been found in G. lucidum and has diverse biological activities.1,2,3 It inhibits HIV-1 protease with an IC50 value of 0.17 mM.1 Ganoderic acid B is cytotoxic to HepG2 and Caco-2 cells (IC50s = 0.65 and 0.36 mg/ml, respectively).2 It inhibits acetic acid-induced writhing in mice by 48.3% when administered at a dose of 5 mg/kg.3
1.El-Mekkawy, S., Meselhy, M.R., Nakamura, N., et al.Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidumPhytochemistry49(6)1651-1657(1998) 2.Ruan, W., Lim, A.H.H., Huang, L.G., et al.Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growthNat. Prod. Res.28(24)2264-2272(2014) 3.Koyama, K., Imaizumi, T., Akiba, M., et al.Antinociceptive components of Ganoderma lucidumPlanta Med.63(3)224-227(1997)