Biotin sulfone is an oxidized form of biotin .1 It binds to avidin with a binding ratio of 0.332 compared with biotin.2 Biotin sulfone has been used to immobilize oligosaccharides on avidin-coated surfaces for the detection of anti-C. albicans antibodies.1
1.Collot, M., Sendid, B., Fievez, A., et al.Biotin sulfone as a new tool for synthetic oligosaccharide immobilization: Application to multiple analysis profiling and surface plasmonic analysis of anti-Candida albicans antibody reactivity against α and β (1→2) oligomannosidesJ. Med. Chem.51(19)6201-6210(2008) 2.Zempleni, J., and Mock, D.M.Advanced analysis of biotin metabolites in body fluids allows a more accurate measurement of biotin bioavailability and metabolism in humansJ. Nutr.129(2S Suppl)494S-497S(1999)