24, 25-Dihydroxy VD2 is a hydroxylated metabolite of vitamin D2, and a synthetic vitamin D analog. 24,25-Dihydroxy VD2 is produced from 25-hydroxyvitamin D2 by the action of renal 24-hydroxylase (CYP24A1) and represents the first step of vitamin D catabolism and an important auto-regulatory mechanism[1-2].
References:
[1] Luo C, Yan X, Yang S, et al. Antiviral activity of vitamin D derivatives against severe fever with thrombocytopenia syndrome virus in vitro and in vivo. Virol Sin. 2024 Oct;39(5):802-811.
[2] Le J, Yuan TF, Geng JQ, et al. Acylation derivatization based LC-MS analysis of 25-hydroxyvitamin D from finger-prick blood. J Lipid Res. 2019 May;60(5):1058-1064..
24, 25-Dihydroxy VD2 是一种维生素D2的羟基化代谢产物,是合成的维生素D类似物。24,25-Dihydroxy VD2由25-羟基维生素D2在肾脏24-羟化酶(CYP24A1)作用下生成,是维生素D分解代谢的第一步和重要的自身调节机制[1-2]。
















