GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC34412 structure
    GC34412Lurasidone metabolite 14326 hydrochloride

    Lurasidonemetabolite14326(hydrochloride)是一种非典型抗精神病药物Lurasidone的活性代谢物。

  • GC34413 structure
    GC34413Lurasidone Metabolite 14283 D8

    LurasidoneMetabolite14283D8是LurasidoneMetabolite14283的氘代化合物标准品。

  • GC34414 structure
    GC34414AZ7550 Mesylate (AZ7550 trimesylate salt)

    An active metabolite of AZ 9291

  • GC34417 structure
    GC34417(R,S)-Ivosidenib ((R,S)-AG-120)

    (R,S)-Ivosidenib是一种异柠檬酸脱氢酶(IDH1)抑制剂。

  • GC34442 structure
    GC34442(R)-(+)-Citronellal
    CAS: 2385-77-5
    纯度: >98.00% / >88.00%

    (R)-(+)-Citronellal可从柑橘、薰衣草和桉树油中分离得到，是一种单萜化合物，是香茅醛的主要成分，具有独特的柠檬香味。是一种调味剂。可用于驱虫和抗真菌。

  • GC34513 structure
    GC34513C25-140
    CAS: 1358099-18-9
    纯度: >98.00%

    C25-140是一种能够抑制TRAF6-Ubc13相互作用的小分子化合物，能够直接与E3连接酶TNF受体相关因子6（TRAF6）结合，从而阻断TRAF6与Ubc13的相互作用，并因此降低TRAF6的活性。

  • GC34539 structure
    GC34539Col003
    CAS: 328565-16-8
    纯度: >95.00%

    Col003是一种有效的Hsp47抑制剂，竞争性地与Hsp47上的胶原结蛋白合位点结合(IC50，1.8μM)，通过破坏胶原蛋白的三重螺旋结构抑制胶原蛋白的分泌。

  • GC34609 structure
    GC34609Guanosine 5'-diphosphate disodium salt
    CAS: 7415-69-2
    纯度: >98.00% / >99.00% / >95.00%

    Guanosine 5'-diphosphate disodium salt作为一种关键的核苷二磷酸，通过G蛋白信号转导作为细胞内信号级联反应的调节剂。

  • GC34613 structure
    GC34613HFI-142
    CAS: 332164-34-8
    纯度: >99.00%

    HFI-142是胰岛素调节性氨基肽酶(IRAP)抑制剂，ki值为2.01μM。

  • GC34634 structure
    GC34634JG-98
    CAS: 1456551-16-8
    纯度: >98.00%

    JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.

  • GC34682 structure
    GC34682N-Ethylmaleimide
    CAS: 128-53-0
    纯度: >99.50% / >98.00%

    N-乙基马来酰亚胺（N-Ethylmaleimide；NEM）衍生于马来酸，能烷基化游离巯基，是一种蛋白质巯基修饰剂，可用于修饰蛋白质和多肽中的半胱氨酸残基。N-Ethylmaleimid对脯氨酰内肽酶有抑制作用，IC 50 值为6.3μM。

  • GC34831 structure
    GC34831Tauroursodeoxycholate dihydrate
    CAS: 117609-50-4
    纯度: >98.00%

    Tauroursodeoxycholatedihydrate(TUDCAdihydrate;UR906dihydrate;Taurolitedihydrate)是一种内质网应激抑制剂。Tauroursodeoxycholate显著降低凋亡分子如caspase-3和caspase-12表达。Tauroursodeoxycholate也抑制ERK。

  • GC34881 structure
    GC348815-Methyltetrahydrofolic acid
    CAS: 134-35-0
    纯度: >99.00%

    5-Methyltetrahydrofolicacid是一种具有生物活性的叶酸形式。5-Methyltetrahydrofolicacid是四氢叶酸的甲基化衍生物。5-Methyltetrahydrofolicacid是主要的天然膳食叶酸，是血浆和脑脊液中叶酸的主要形式。

  • GC34914 structure
    GC34914LysoPC(14:0/0:0)
    CAS: 20559-16-4
    纯度: >98.00%

    A lysophospholipid

  • GC34924 structure
    GC34924NSC 185058
    CAS: 39122-38-8
    纯度: >98.00%

    NSC 185058是一种ATG4B的合成抑制剂，IC 50 值为51μM。

  • GC34951 structure
    GC34951(-)-Menthol
    CAS: 2216-51-5
    纯度: >98.00%

    A monoterpene with diverse biological activities

  • GC34961 structure
    GC34961(±)-BI-D
    CAS: 1416258-16-6
    纯度: >98.00%

    (_plusmn_)-BI-D是HIV整合酶（integrase）变构抑制剂，作用于整合酶与LEDGF/p75结合部位。

  • GC35003 structure
    GC35003(S)-Nornicotine
    CAS: 494-97-3
    纯度: >97.00%

    (S)-Nornicotine 是尼古丁的代谢物。

  • GC35029 structure
    GC350291-Arachidoyl-sn-glycero-3-phosphocholine
    CAS: 108341-80-6
    纯度: >99.00%

    1-Arachidoyl-sn-glycero-3-phosphocholine是一种溶血磷脂 (LyP)。

  • GC35039 structure
    GC350391,4-Diaminobutane dihydrochloride
    CAS: 333-93-7

    1,4-Diaminobutane (Putrescine, Tetramethylenediamine, 1,4-Butanediamine) is used as a precursor in many biological systems and synthon for amido-ureas.

  • GC35058 structure
    GC3505816-Dehydroprogesterone
    CAS: 1096-38-4

    16-Dehydroprogesterone is a chemical derived from a progesterone.

  • GC35061 structure
    GC3506118α-Glycyrrhetinic acid
    CAS: 1449-05-4
    纯度: >99.50% / >98.00%

    Glycyrrhetinic acid is a triterpenoid aglycone component of the natural product glycyrrhizinic acid and possesses remarkable anti-proliferative and apoptosis-inducing activity in various cancer cell lines.

  • GC35067 structure
    GC350671-Methylguanosine
    CAS: 2140-65-0
    纯度: >98.00%

    A methylated purine nucleoside

  • GC35068 structure
    GC350681-Monomyristin
    CAS: 589-68-4
    纯度: >98.00%

    A monoacylglycerol