Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC40380 5-OxoETE
5-KETE
A polyunsaturated keto acid?that stimulates neutrophil migration
GC40378 5(S)-HEPE A fatty acid produced by 5-LO oxidation of EPA
GC40376 15-OxoETE
15KETE

An oxylipin produced by oxidation of the 15-hydroxyl of 15-HETE
GC40373 15(S)-HEPE
15S-hydroxy-Eicosapentaenoic Acid
A monohydroxy fatty acid derived from EPA
GC40372 12-OxoETE
12-KETE
A 12-oxo derivative of arachidonic acid
GC40371 12(S)-HEPE An anti-inflammatory monohydroxy fatty acid derived from EPA
GC40368 11(R)-HEPE Produced by the oxidation of EPA by 11(R)-LO
GC40357 9(S)-HpODE A 5-LO product derived from linoleic acid
GC40349 12(S)-HETE-19,20-alkyne
Click Tag 12(S)-HETE-19,20-alkyne, Click Tag 12(S)-Hydroxyeicosatetraenoic Acid-19,20-alkyne
A probe for 12(S)-HETE activity
GC40339 Hepoxilin A3 methyl ester
HxA3 methyl ester
A metabolite of arachidonic acid
GC40301 Tamoxifen N-oxide
他莫昔芬N-氧化物
A metabolite of tamoxifen
GC40298 N-acetyl-5-Aminosalicylic Acid
5-乙酰氨基水杨酸
A metabolite of 5-ASA and sulfasalazine
GC40286 (E,Z)-2-propyl-2-Pentenoic Acid
2-丙基-2-戊烯酸
A valproic acid metabolite
GC40278 Leukotriene B3
LTB3
The LTA hydrolase metabolite of LTA₃
GC40265 Pheleuin A pyrazinone
GC40260 (±)-γ-Tocopherol
3,4-二氢-2,7,8-三甲基-2-(4,8,12-三甲基十三烷)-2H-1-苯并吡喃-6-醇
A form of vitamin E
GC40259 (±)-β-Tocopherol
β-生育酚
A lipid-soluble form of vitamin E
GC10559 Erythrodiol
高根二醇,Oleanolic alcohol; olean-12-ene-3,28-diol; ERYTHODIOL; Erythrodiol; 12-OLEANENE-3,28-DIOL; HOMOOLESTRANOL;
A triterpene with diverse biological activities
GC10456 Fucosterol
岩皂甾醇,24-ethylidene Cholesterol
A natural phytosterol with diverse biological activities
GC19523 Sivelestat sodium tetrahydrate
EI546 sodium tetrahydrate; LY544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate
An inhibitor of neutrophil elastase
GC34924 NSC 185058 NSC 185058是一种ATG4B的合成抑制剂，IC₅₀值为51μM。
GC34914 LysoPC(14:0/0:0)
1-十四酰-2-羟基卵磷脂
A lysophospholipid
GC34881 5-Methyltetrahydrofolic acid
甲基叶酸盐,5-Methyl THF
5-Methyltetrahydrofolicacid是一种具有生物活性的叶酸形式。5-Methyltetrahydrofolicacid是四氢叶酸的甲基化衍生物。5-Methyltetrahydrofolicacid是主要的天然膳食叶酸，是血浆和脑脊液中叶酸的主要形式。
GC34831 Tauroursodeoxycholate dihydrate
牛磺熊去氧胆酸二水合物; Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate
Tauroursodeoxycholatedihydrate(TUDCAdihydrate;UR906dihydrate;Taurolitedihydrate)是一种内质网应激抑制剂。Tauroursodeoxycholate显著降低凋亡分子如caspase-3和caspase-12表达。Tauroursodeoxycholate也抑制ERK。
GC34682 N-Ethylmaleimide
N-乙基马来酰亚胺; NEM
N-乙基马来酰亚胺（N-Ethylmaleimide；NEM）衍生于马来酸，能烷基化游离巯基，是一种蛋白质巯基修饰剂，可用于修饰蛋白质和多肽中的半胱氨酸残基。N-Ethylmaleimid对脯氨酰内肽酶有抑制作用，IC₅₀值为6.3μM。
GC34634 JG-98
3-苄基-2-((Z)-((E)-5-(6-氯-3-甲基苯并[D]噻唑-2(3H)-亚基)-3-乙基-4-氧代噻唑啉-2-亚基)甲基)噻唑-3-鎓氯化物
JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.
GC34613 HFI-142 HFI-142是胰岛素调节性氨基肽酶(IRAP)抑制剂，ki值为2.01μM。
GC34609 Guanosine 5'-diphosphate disodium salt
鸟苷-5'-二磷酸二钠盐,GDP disodium salt
Guanosine 5'-diphosphate disodium salt作为一种关键的核苷二磷酸，通过G蛋白信号转导作为细胞内信号级联反应的调节剂。
GC34539 Col003
Col003是一种有效的Hsp47抑制剂，竞争性地与Hsp47上的胶原结蛋白合位点结合(IC50，1.8μM)，通过破坏胶原蛋白的三重螺旋结构抑制胶原蛋白的分泌。
GC34513 C25-140 C25-140是一种能够抑制TRAF6-Ubc13相互作用的小分子化合物，能够直接与E3连接酶TNF受体相关因子6（TRAF6）结合，从而阻断TRAF6与Ubc13的相互作用，并因此降低TRAF6的活性。
GC34442 (R)-(+)-Citronellal
(R)-(+)-香茅醛; (+)-Citronellal
(R)-(+)-Citronellal可从柑橘、薰衣草和桉树油中分离得到，是一种单萜化合物，是香茅醛的主要成分，具有独特的柠檬香味。是一种调味剂。可用于驱虫和抗真菌。
GC19520 Cysteine Protease inhibitor
半胱氨酸蛋白酶抑制剂
半胱氨酸蛋白酶抑制剂是半胱氨酸蛋白酶的抑制剂。
GP24824 Thrombin 人类凝血酶
GP24734 Streptolysin-O 链球菌溶血素-O 化脓性链球菌重组体
GC19495 DL-Folinic Acid (calcium salt)
亚叶酸钙; Leucovorin calcium; Calcium folinate
A reduced folic acid
GC40256 p-APMSF (hydrochloride)
(4-脒苯基)甲磺酰氟盐酸盐
An irreversible inhibitor of serine proteases
GC40252 Phosphatidic Acids (egg) (ammonium salt) A mixture of phosphatidic acids
GC40234 Ramipril-d5
雷米普利 d5
An internal standard for the quantification of ramipril
GC40229 (±)-Warfarin-d5
4-羟基-3-[3-氧代-1-(苯基-D5)丁基]-2H-1-苯并吡喃-2-酮,WARF-42-d5; Athrombine-K-d5
An internal standard for the quantification of warfarin
GC40221 Ritonavir-d6
利托那韦 d6
An internal standard for the quantification of ritonavir
GC40220 Pravastatin-d3 (sodium salt) An internal standard for the quantification of pravastatin
GC40218 (-)-Epigallocatechin Gallate-d3/d4
EGCG-d3/d4
An internal standard for the quantification of (–)-epigallocatechin gallate
GC40191 Ibuprofen Carboxylic Acid
羧基布洛芬
A major metabolite of ibuprofen
GC40190 Febuxostat Acyl Glucuronide
非布司他杂质
A metabolite of febuxostat
GC40183 1-Oleoyl Glycerol
甘油单油酸酯
A monoacylglycerol
GC40164 Ac-IETD-CHO (trifluoroacetate salt)
Caspase-8 Inhibitor
Ac-IETD-CHO (trifluoroacetate salt)是一种caspase 8抑制剂，可阻止focal adhesion kinase (Fak)被caspase裂解，IC₅₀值为200nM。
GC40149 Boc-AEVD-CHO (trifluoroacetate salt)
Boc-Ala-Glu-Val-Asp-CHO
An inhibitor of caspase-8
GC40145 (S)-Laudanosine
(+)-Laudanosine, L-Laudanosine, L-(+)-Laudanosine, NSC 35045
The (S) enantiomer of laudanosine
GC40144 Levofloxacin N-oxide
左氧氟沙星EP杂质C (Levofloxacin N-Oxide)
An inactive metabolite of levofloxacin
GC40143 Dihydrotetrabenazine
反式(2,3)-二氢丁苯那嗪
An active metabolite of tetrabenazine