N1-Methylguanosine (m1G) is a methylated purine nucleoside formed during the degradation of tRNA and a biological end product.1,2 Levels of m1G are increased in the urine of patients with malignant tumors compared to those with benign or no tumors and have been used as biomarkers of cancer.3,1
1.Liebich, H.M., Müller-Hagedorn, S., Klaus, F., et al.Chromatographic, capillary electrophoretic and matrix-assisted laser desorption ionization time-of-flight mass spectrometry analysis of urinary modified nucleosides as tumor markersJ. Chromatogr. A.1071(1-2)271-275(2005) 2.Mitchell, E.P., Evans, L., Schultz, P., et al.Modified nucleosides in human serumJ. Chromatogr.581(1)31-40(1992) 3.Seidel, A., Brunner, S., Seidel, P., et al.Modified nucleosides: An accurate tumour marker for clinical diagnosis of cancer, early detection and therapy controlBr. J. Cancer.94(11)1726-1733(2006)