Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC3401611beta-Hydroxyprogesterone (11β-Hydroxyprogesterone)CAS: 600-57-7纯度: >99.50% / >98.00%
A metabolite of progesterone
- GC34027N-Acetylprocainamide (Acecainide)CAS: 32795-44-1纯度: >98.00%
N-Acetylprocainamide (Accecainide) 是一种 III 类抗心律失常药，可阻断 K+ 通道。
- GC34032Napsagatran hydrate (Ro 46-6240 hydrate)CAS: 159668-20-9
Napsagatran hydrate (Ro 46-6240 hydrate) 是一种新型的特异性凝血酶抑制剂。
- GC34040Fosfructose trisodium (Diphosphofructose (trisodium))CAS: 38099-82-0纯度: >99.00%
D-Fructose-1,6-diphosphate trisodium salt octahydrate (FBP trisodium salt octahydrate), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway.
- GC34052Fosfructose (Diphosphofructose)CAS: 488-69-7
Fosfructose (Diphosphofructose) (Diphosphofructose;Esafosfan;FDP) 是一种具有细胞保护作用的天然磷酸糖，可用于治疗心血管缺血、镰状细胞性贫血和哮喘。
- GC34092Glycochenodeoxycholic acid (Chenodeoxycholylglycine)CAS: 640-79-9纯度: >98.00%
A quantitative analytical standard guaranteed to meet MaxSpec ? identity, purity, stability, and concentration specifications
- GC34113N-(5-Aminopentyl)acetamide (Monoacetylcadaverine)CAS: 32343-73-0纯度: >98.00%
N-(5-Aminopentyl)acetamide (Monoacetylcadaverine, N-Acetylcadaverine) is the acetylated form of the polyamine cadaverine, which is a foul-smelling diamine compound.
- GC34134Glycocholic acidCAS: 475-31-0纯度: >98.00% / >97.00%
Glycocholic acid是一种参与脂肪乳化的结晶胆汁酸，是胆酸与甘氨酸的结合物，它以钠盐的形式存在于哺乳动物的胆汁中。
- GC341792-Methoxybenzoic acid (NSC 3778)CAS: 579-75-9纯度: >99.00%
2-Methoxybenzoic acid (o-Anisic acid) is a flavouring agent.
- GC34181Tauroursodeoxycholate (TUDCA)CAS: 14605-22-2纯度: >98.00%
牛磺酸脱氧胆酸盐(TUDCA)是包括肝细胞在内的多种细胞的细胞保护剂,也是癌症细胞凋亡的诱导剂。
- GC341932-(4-Methoxyphenyl)acetic acid (4-Methoxyphenylacetic acid)CAS: 104-01-8纯度: >99.50%
2-(4-Methoxyphenyl)acetic acid (p-Anisylacetic acid, 4-Methoxyphenylacetic acid) is a 4-O-Methylated catecholamine metabolite found in normal human urine, cerebrospinal fluid and brain tissue.
- GC34324ZK824859 hydrochloride纯度: >99.00%
ZK824859hydrochloride是一种口服有效的选择性尿激酶型纤溶酶原激活剂(uPA)抑制剂，用于人uPA，tPA和纤溶酶，IC50分别为79nM，1580nM和1330nM。
- GC34411Lurasidone Metabolite 14326 D8
LurasidoneMetabolite14326D8是LurasidoneMetabolite14326的氘代化合物标准品。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC34016 | 11beta-Hydroxyprogesterone (11β-Hydroxyprogesterone) | 600-57-7 | >99.50% / >98.00% | |
A metabolite of progesterone | ||||
| GC34019 | Omapatrilat (BMS-186716) | 167305-00-2 | >99.50% / >98.00% | |
An ACE and NEP inhibitor | ||||
| GC34021 | Vitamin K4 (acetomenaphthone) | 573-20-6 | >99.50% | |
A synthetic form of vitamin K | ||||
| GC34027 | N-Acetylprocainamide (Acecainide) | 32795-44-1 | >98.00% | |
N-Acetylprocainamide (Accecainide) 是一种 III 类抗心律失常药，可阻断 K+ 通道。 | ||||
| GC34032 | Napsagatran hydrate (Ro 46-6240 hydrate) | 159668-20-9 | - | |
Napsagatran hydrate (Ro 46-6240 hydrate) 是一种新型的特异性凝血酶抑制剂。 | ||||
| GC34040 | Fosfructose trisodium (Diphosphofructose (trisodium)) | 38099-82-0 | >99.00% | |
D-Fructose-1,6-diphosphate trisodium salt octahydrate (FBP trisodium salt octahydrate), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. | ||||
| GC34052 | Fosfructose (Diphosphofructose) | 488-69-7 | - | |
Fosfructose (Diphosphofructose) (Diphosphofructose;Esafosfan;FDP) 是一种具有细胞保护作用的天然磷酸糖，可用于治疗心血管缺血、镰状细胞性贫血和哮喘。 | ||||
| GC34092 | Glycochenodeoxycholic acid (Chenodeoxycholylglycine) | 640-79-9 | >98.00% | |
A quantitative analytical standard guaranteed to meet MaxSpec ? identity, purity, stability, and concentration specifications | ||||
| GC34113 | N-(5-Aminopentyl)acetamide (Monoacetylcadaverine) | 32343-73-0 | >98.00% | |
N-(5-Aminopentyl)acetamide (Monoacetylcadaverine, N-Acetylcadaverine) is the acetylated form of the polyamine cadaverine, which is a foul-smelling diamine compound. | ||||
| GC34123 | Deoxycytidine triphosphate (dCTP) | 2056-98-6 | - | |
脱氧胞苷三磷酸 (dCTP) (dCTP) 是一种核苷三磷酸，可用于 DNA 合成。 | ||||
| GC34134 | Glycocholic acid | 475-31-0 | >98.00% / >97.00% | |
Glycocholic acid是一种参与脂肪乳化的结晶胆汁酸，是胆酸与甘氨酸的结合物，它以钠盐的形式存在于哺乳动物的胆汁中。 | ||||
| GC34179 | 2-Methoxybenzoic acid (NSC 3778) | 579-75-9 | >99.00% | |
2-Methoxybenzoic acid (o-Anisic acid) is a flavouring agent. | ||||
| GC34181 | Tauroursodeoxycholate (TUDCA) | 14605-22-2 | >98.00% | |
牛磺酸脱氧胆酸盐(TUDCA)是包括肝细胞在内的多种细胞的细胞保护剂,也是癌症细胞凋亡的诱导剂。 | ||||
| GC34193 | 2-(4-Methoxyphenyl)acetic acid (4-Methoxyphenylacetic acid) | 104-01-8 | >99.50% | |
2-(4-Methoxyphenyl)acetic acid (p-Anisylacetic acid, 4-Methoxyphenylacetic acid) is a 4-O-Methylated catecholamine metabolite found in normal human urine, cerebrospinal fluid and brain tissue. | ||||
| GC34255 | TP508 | 121341-81-9 | - | |
TP508是由23个氨基酸残基构成的多肽，它代表了人凝血素的第508-530位氨基酸序列，被认为是高亲和性受体与凝血素的结合域。 | ||||
| GC34287 | AZ7550 hydrochloride | 2309762-40-9 | - | |
An active metabolite of AZ 9291 | ||||
| GC34324 | ZK824859 hydrochloride | - | >99.00% | |
ZK824859hydrochloride是一种口服有效的选择性尿激酶型纤溶酶原激活剂(uPA)抑制剂，用于人uPA，tPA和纤溶酶，IC50分别为79nM，1580nM和1330nM。 | ||||
| GC34331 | Gln-AMS TFA | - | - | |
Gln-AMS(TFA)是Ia类型的氨酰基-tRNA合成酶(AARS)抑制剂。Gln-AMS抑制谷氨酰胺酰-tRNA合成酶的Ki值为1.32µM。 | ||||
| GC34358 | Leu-AMS R enantiomer | - | - | |
Leu-AMSRenantiomer是Leu-AMS的R对映体。Leu-AMS是亮氨酰-tRNA合成酶(LRS)的有效抑制剂并抑制细菌的生长。 | ||||
| GC34373 | Dabigatran D4 hydrochloride (BIBR-953 D4 hydrochloride) | - | - | |
DabigatranD4盐酸盐是Dabigatran氘代化合物标准品。 | ||||
| GC34408 | Monohydroxy Netupitant D6 | - | - | |
MonohydroxyNetupitantD6是MonohydroxyNetupitant的氘代化合物标准品。 | ||||
| GC34409 | Netupitant N-oxide D6 | - | - | |
NetupitantN-oxideD6是NetupitantN-oxide的氘代化合物标准品。 | ||||
| GC34410 | N-desmethyl Netupitant D6 | - | - | |
N-desmethylNetupitantD6是N-desmethylNetupitant的氘代化合物标准品。 | ||||
| GC34411 | Lurasidone Metabolite 14326 D8 | - | - | |
LurasidoneMetabolite14326D8是LurasidoneMetabolite14326的氘代化合物标准品。 | ||||