Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC40839 15(S)-HETE methyl ester
15(S)-Hydroxyeicosatetraenoic Acid methyl ester
A synthetic derivative of 15(S)-HETE
GC40834 cis-Entacapone
(2Z)-2-氰基-3-(3,4-二羟基-5-硝基苯基)-N,N-二乙基-2-丙烯酰胺
A metabolite of entacapone
GC40830 5,6-dehydro Arachidonic Acid
5,6dehydro AA
An analog of arachidonic acid with acetylene in the 5,6 position
GC40829 5(S)-HETE lactone
5(S)-Hydroxyeicosatetraenoic Acid lactone
A potential 5-LO inhibitor
GC40828 (±)5-HETE lactone
(±)5-Hydroxyeicosatetraenoic Acid lactone
A 5-LO inhibitor
GC40801 (±)9(10)-DiHOME
(±)-苏式-9,10-二羟基-12(Z)-十八碳烯酸
A diol form of (±)9(10)-EpOME
GC40794 Sphinganine (d18:0)
D-赤式-C18-二氢-D-神经鞘氨醇
Sphinganine (d18:0)是一种鞘脂代谢途径的中间体。
GC40784 5(Z),8(Z),14(Z)-Eicosatrienoic Acid A polyunsaturated fatty acid
GC40777 β-D-Glucose
D-无水葡萄糖
A cyclic monosaccharide
GC40769 Asperphenamate
Anabellamide, Auranamide, NSC 306231
A fungal secondary metabolite
GC40758 Gly-Phe-β-naphthylamide
(S)-2-(2-氨基乙酰氨基)-N-(萘-2-基)-3-苯基丙酰胺
A cathepsin C substrate
GC40743 3-deoxy Galactosone
3-脱氧-山梨糖酮
A galactose degradation product
GC40730 11-cis Vaccenyl Acetate Male mating pheromone of D. melanogaster
GC40724 Heat Shock Protein Inhibitor II
Hsp Inhibitor II, KNK 423
Prevents the synthesis of inducible heat shock proteins
GC40719 β-Muricholic Acid
Β-鼠胆酸,5β-Cholanic Acid-3α,6β,7β-triol, β-MCA
β-胆酸β-muricholic acid是一种天然存在的三羟基亲水性胆汁酸，作为胆道胆固醇去饱和剂，促进胆固醇胆结石的溶解。
GC40718 α-Muricholic Acid
5β-Cholanic Acid-3α,6β,7α-triol
A murine-specific primary bile acid
GC40697 DDA
(2E,4E)-癸-2,4-二烯醛
A lipid decomposition product with cancer inhibiting activity
GC40694 Calpain Inhibitor II
Calpain inhibitor II
A non-selective cysteine protease inhibitor
GC40677 Avenaciolide
(±)-Avenaciolide
A fungal metabolite
GC40675 2-deoxy-Artemisinin
脱氧青蒿素
An inactive metabolite of artemisinin
GC40669 Nerol
橙花醇
A monoterpene
GC40665 Harzianopyridone
(-)-Harzianopyridone
An inhibitor of mitochondrial complex II
GC40661 D-Carnitine
右旋肉碱
An isomer of L-carnitine
GC40631 Leukotriene B4-3-aminopropylamide
LTB4-3aminopropylamide
A potent BLT₁ receptor ligand
GC40627 tetranor-Misoprostol A metabolite of misoprostol
GC40624 MMP-3 Inhibitor VIII
Matrix Metalloproteinase-3 Inhibitor VIII, Stromelysin-1 Inhibitor VIII
A selective inhibitor of MMP-3
GC40620 Heneicosanoic Acid
二十一碳酸
A very long-chain saturated fatty acid
GC40616 Des-4-fluorobenzyl Mosapride
莫沙必利脱氟苄基杂质
A metabolite of mosapride
GC40612 Resolvin E1
RvE1

A specialized pro-resolving mediator
GC40609 Lipoxin A5
LXA5
An EPA-derived bronchoconstrictor
GC40555 Tiopronin
BRN 1859822, (±)-Tiopronin
Tiopronin is an antioxidant that has diverse biological activities.
GC40542 9(R)-HODE
9(R)-Hydroxyoctadecadienoic Acid
A linoleic acid metabolite
GC40539 (±)12(13)-EpOME
(±)12,13-EODE, Isoleukotoxin, (±)-Vernolic Acid
The 12,13-cis epoxide form of linoleic acid
GC40538 Decylubiquinone
癸基泛醌
An analog of ubiquinone (coenzyme Q₁₀)
GC40529 7-hydroxy Warfarin
7-羟基华法林
A phase I metabolite of (-)-warfarin
GC40495 DL-Mevalonolactone
甲瓦龙酸内酯,(±)-Mevalonolactone; Mevalolactone
A precursor in the mevalonate pathway
GC40480 α-Phenyl-α-(2-pyridyl)acetonitrile
alpha-(2-吡啶基)-苯乙腈
The major metabolite of α-phenyl-α-(2-pyridyl)thioacetamide
GC40463 8(S)-HETE
8(S)-Hydroxyeicosatetraenoic Acid
A PKC and PPARα activator
GC40462 8(R)-HETE
8(R)-Hydroxyeicosatetraenoic Acid
A product of lipoxygenation of arachidonic acid in marine invertebrates
GC40459 5(R)-HETE
5(R)-Hydroxyeicosatetraenoic Acid
A rare lipoxygenase product of arachidonic acid
GC40451 15(S)-HETE
15(S)-Hydroxyeicosatetraenoic Acid
An active metabolite of arachidonic acid
GC40448 12(S)-HETE
12(S)-Hydroxyeicosatetraenoic Acid
The predominant lipoxygenase product of mammalian platelets
GC40447 12(R)-HETE
12(R)-Hydroxyeicosatetraenoic Acid
An active metabolite of arachidonic acid
GC40445 11(R)-HETE
11(R)-Hydroxyeicosatetraenoic Acid
An oxylipin
GC40442 (±)8-HETE
(±)8-Hydroxyeicosatetraenoic Acid
A monohydroxy fatty acid produced by the non-enzymatic oxidation of arachidonic acid
GC40427 15(S)-HEDE Isolated by the chromatographic resolution of (±)15-HEDE
GC40399 Linoelaidic Acid
亚麻酸; Linoelaidic acid
An all-trans fatty acid homolog of linoleic acid
GC40394 11-deoxy Corticosterone
去氧皮质酮
11-deoxy Corticosterone是一种由肾上腺产生的类固醇激素，具有盐皮质激素活性，并作为醛固酮的前体。
GC40383 9(S)-HEPE A monohydroxy fatty acid derived from EPA
GC40382 8(S)-HEPE A monohydroxy fatty acid produced by lipoxygenase oxidation of EPA