Vitamin K4 is a synthetic form of vitamin K and the diacetate form of the provitamin vitamin K3 .1,2 It inhibits proliferation of PC3 prostate cancer cells (IC50 = 20.94 ?M).1 Vitamin K4 (20 and 40 ?M) induces cell cycle arrest at the S phase and mitochondrial apoptosis in PC3 cells. It inhibits canonical and non-canonical activation of the NOD-like receptor protein 3 (NLRP3) inflammasome in mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 5 ?M.2 Vitamin K4 (4 mg/kg) decreases the production of IL-1β and peritoneal neutrophil infiltration in a mouse model of monosodium urate-induced NLRP3-dependent peritonitis.
1.Jiang, Y., Yang, J., Yang, C., et al.Vitamin K4 induces tumor cytotoxicity in human prostate carcinoma PC-3 cells via the mitochondria-related apoptotic pathwayPharmazie68(8)442-448(2013) 2.Zheng, X., Hou, Y., He, H., et al.Synthetic vitamin K analogs inhibit inflammation by targeting the NLRP3 inflammasomeCell Mol. Immunol.(2020)