GlpBio

Dimethylfraxetin

目录号: GN10531纯度: >99.50%同义词: 二甲基白蜡树亭,6,7,8-Trimethoxycoumarin; Fraxetin dimethyl ether
A coumarin with anti-inflammatory activity
Dimethylfraxetin
Cas No.: 6035-49-0
规格价格库存数量操作
20mg¥3,318.00现货
1
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    641, 529–536 (2025)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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产品描述 Description

Dimethylfraxetin is a Carbonic anhydrase inhibitor, with a Ki value of 0.0097 μM.

At CA I there is one stand out compound being Dimethylfraxetin (compound 17), a nanomolar CA I inhibitor. This trimethoxy coumarin is the most potent of any of the NP coumarins across the six CA isozymes of the present study[1].

References:
[1]. Davis RA, et al. Natural product coumarins that inhibit human carbonic anhydrases. Bioorg Med Chem. 2013 Mar 15;21(6):1539-43.

实验参考方法 Experimental Reference Method

Kinase experiment:

Inhibitor (including Dimethylfraxetin) and enzyme solutions are preincubated together for 6 h at room temperature prior to assay, in order to allow for the formation of the enzyme-inhibitor complex[1].

References:

[1]. Davis RA, et al. Natural product coumarins that inhibit human carbonic anhydrases. Bioorg Med Chem. 2013 Mar 15;21(6):1539-43.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
6035-49-0
同义词
二甲基白蜡树亭,6,7,8-Trimethoxycoumarin; Fraxetin dimethyl ether
化学名
6,7,8-trimethoxychromen-2-one
SMILES
COC1=C(C(=C2C(=C1)C=CC(=O)O2)OC)OC
分子式
C12H12O5
分子量
236.22 g/mol
溶解性
≥ 73.1mg/mL in DMSO
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol