GlpBio

KEAP1-Nrf2

The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.

KEAP1-Nrf2 相关产品(65)

  • GC14352 structure
    GC14352TAT 14
    CAS: 1362661-34-4
    纯度: >98.00%

    TAT 14 是一种 14 聚体肽，可作为具有抗炎作用的 Nrf2 激活剂。

  • GC14787 structure
    GC14787Curcumin
    CAS: 458-37-7
    纯度: >98.00%

    A yellow pigment with diverse biological activities

  • GC15371 structure
    GC15371Bardoxolone
    CAS: 218600-44-3
    纯度: >98.00%

    An anti-inflammatory compound that activates Nrf2/ARE signaling

  • GC16120 structure
    GC16120AI-3
    CAS: 882288-28-0

    Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor

  • GC16590 structure
    GC16590Dimethyl Fumarate
    CAS: 624-49-7
    纯度: >97.00%

    An antioxidant with immunological actions

  • GN10531 structure
    GN10531Dimethylfraxetin
    CAS: 6035-49-0
    纯度: >99.50%

    A coumarin with anti-inflammatory activity

  • GC11302 structure
    GC11302Hinokitiol
    CAS: 499-44-5
    纯度: >99.50% / >98.00%

    Hinokitiol是一种在 Formosan cypress 中天然存在的tropolone类化合物，具有抗菌和抗癌特性。

  • GC11572 structure
    GC11572Bardoxolone methyl
    CAS: 218600-53-4
    纯度: >98.50%

    Bardoxolone methyl是核因子红细胞2相关因子2（Nrf2）介导的抗氧化和抗炎反应的有效激活剂，也是NF-κB通路的抑制剂。

  • GC12821 structure
    GC12821Oltipraz
    CAS: 64224-21-1
    纯度: >99.50%

    A Nrf2 and CAR activator

  • GC13058 structure
    GC13058NK 252
    CAS: 1414963-82-8
    纯度: >98.00%

    A Nrf2 activator

  • GC13693 structure
    GC13693Omaveloxolone (RTA-408)
    CAS: 1474034-05-3
    纯度: >99.00% / >98.00%

    Omaveloxolone (RTA-408)是一种抗氧化炎症调节剂（AIM），可激活Nrf2并抑制一氧化氮（NO）的生成。

  • GC15355 structure
    GC153552-Trifluoromethyl-2'-methoxychalcone
    CAS: 1309371-03-6
    纯度: >98.00%

    A potent activator of Nrf2

  • GC15457 structure
    GC15457Pyridoxine
    CAS: 65-23-6
    纯度: >98.00% / >99.50%

    A 4-methanol form of vitamin B 6

  • GC15605 structure
    GC15605Ezetimibe
    CAS: 163222-33-1
    纯度: >99.50% / >99.00%

    Ezetimibe是一种选择性胆固醇吸收抑制剂，对肺癌细胞(A549)和人胚肾细胞(HEK293)的IC 50 为50µM，对黑色素瘤细胞(A375)的IC 50 为30µM，作用时间均为48h。

  • GC17393 structure
    GC17393Pyridoxine HCl
    CAS: 58-56-0
    纯度: >99.50%

    Pyridoxine HCl是维生素B6的盐酸盐形式，具有抗氧化剂的作用。

  • GC19254 structure
    GC19254ML385
    CAS: 846557-71-9
    纯度: >98.00% / >99.50%

    ML385是一种特定的核因子红细胞2相关因子2（NRF2）抑制剂。

  • GC31321 structure
    GC31321KI696
    CAS: 1799974-70-1
    纯度: >99.00%

    KI696是一种干扰Keap1/NRF2相互作用的高亲和力探针。

  • GC31648 structure
    GC316484-Octyl Itaconate
    CAS: 3133-16-2
    纯度: >98.00%

    4-Octyl Itaconate (4-OI) 是一种可渗透细胞的衣康酸酯衍生物。

  • GC31691 structure
    GC31691(+)-DHMEQ
    CAS: 287194-41-6
    纯度: >99.50%

    (+)-DHMEQ 是抗氧化转录因子 Nrf2 的激活剂。

  • GC31783 structure
    GC31783Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester)
    CAS: 2150-43-8
    纯度: >98.00%

    Methyl protocatechuate (Methyl 3,4-dihydroxybenzoate, 3,4-Dihydroxybenzoic acid methyl ester, Protocatechuic Acid Methyl Ester) is also known as Protocatechuic Acid Methyl Ester. Protocatechuic Acid, a dihydroxybenzoic acid, is a major metabolite of antioxidant polyphenols found in green tea with antioxidant and anti-inflammatory effects.

  • GC32723 structure
    GC32723CDDO-Im (RTA-403)
    CAS: 443104-02-7
    纯度: >98.00%

    CDDO-Im (RTA-403)是一种合成三萜类化合物，通过与Kelch样ECH相关蛋白1（Keap1）结合抑制核因子E2相关因子（Nrf2）的降解，从而激活Nrf2信号通路并提高其蛋白水平。

  • GC33092 structure
    GC33092Hesperin
    CAS: 4430-35-7
    纯度: >98.00%

    An isothiocyanate with diverse biological activities

  • GC33815 structure
    GC338154-Hydroxyphenylacetic acid
    CAS: 156-38-7
    纯度: >99.00%

    A phenolic acid with anti-inflammatory and anti-steatotic activities

  • GC34010 structure
    GC34010Danshensu (Dan shen suan A)
    CAS: 76822-21-4
    纯度: >98.00%

    丹参素是丹参的一种活性成分，通过激活 Nrf2 信号通路显示出广泛的心血管益处。