(S)-Timolol Maleate (L-714,465 Maleate;MK 950), is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively).
(S)-Timolol Maleate (L-714,465 Maleate;MK 950), 50% bioavailability following oral administration. Does not cross the blood brain barrier. Timolol maleate does appear to have some local anesthetic properties in human cornea after chronic use by susceptible individuals.
References:
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