Phenprocoumon is an anticoagulant and vitamin K antagonist.1,2 It inhibits the activity of wild-type vitamin K epoxide reductase (VKOR; IC50 = 4.2 nM), as well as a variety of mutant VKORs (IC50s = 5.1-835 nM), in cell-based reporter assays.1 Phenprocoumon inhibits prothrombin complex synthesis in rats in a dose-dependent manner.2 Formulations containing phenprocoumon have previously been used in the prevention and treatment of thromboembolic disorders.
1.Chen, X., Jin, D.-Y., Stafford, D.W., et al.Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieuBlood132(18)1974-1984(2018) 2.Schmidt, W.E., and J?hnchen, E.Stereoselective drug distribution and anticoagulant potency of the enantiomers of phenprocoumon in ratsJ. Pharm. Pharmacol.29(5)266-271(1977)