SIBA (5′-Isobutylthio-5′-deoxyadenosine, 5'-Deoxy-5'-isobutylthioadenosine, 5'-Isobutylthioadenosine) is a synthetic analogue of S-adenosylhomocysteine and is a powerful antipro-liferative drug. SIBA is not only an inhibitor of transmethylation but also interferes with polyamine biosynthesis, probably by blocking aminopropyltransferase.
[1] M Carteni-Farina, et al. FEBS Lett. 1979 Aug 15;104(2):266-70. [2] F Lawrence,, et al. Biochem J. 1982 Jun 15;204(3):853-9.
















