Azumolene is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum.1,2 It inhibits a component of store-operated calcium entry (SOCE) that is coupled to the skeletal muscle ryanodine receptor, with 20 ?M azumolene causing a 70% reduction in SOCE in myotubes.3,4 Azumolene has utility in countering muscle dysfunction associated with malignant hyperthermia.4
1.Palnitkar, S.S., Michelson, J.R., Louis, C.F., et al.Pharmacological distinction between dantrolene and ryanodine binding sites: Evidence from normal and malignant hyperthermia-susceptible porcine skeletal muscleBiochem. J.326 (Pt 3)847-852(1997) 2.Leslie, G.C., and Part, N.J.The effect of EU4093 (azumolene sodium) on the contraction of intrafusal muscle in the soleus muscle of the anaesthetized ratBr. J. Pharmacol.97(4)1151-1156(1989) 3.Zhao, X., Weisleder, N., Han, X., et al.Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptorJ. Biol. Chem.281(44)33477-33486(2006) 4.Yarotskyy, V., Protasi, F., and Dirksen, R.T.Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden deathPLoS One8(10)1-12(2013)