20-Deoxyingenol is a diterpenoid that has been found in E. kansui and has antioxidant and osteoprotective activities.1,2 It inhibits oxidative stress-induced decreases in autophagic flux and apoptosis in isolated mouse chondrocytes when used at a concentration of 10 mM.2 20-Deoxyingenol (20 mg/kg per day, i.p.) reduces bone erosion and cartilage calcification in joints in a mouse model of injury-induced osteoarthritis.
1.Zhang, J.-S., Weng, H.-Z., Huang, J.-L., et al.Anti-inflammatory ingenane diterpenoids from the roots of Euphorbia kansuiPlanta Med.84(18)1334-1339(2018) 2.Gu, M., Jin, J., Ren, C., et al.20-Deoxyingenol alleviates osteoarthritis by activating TFEB in chondrocytesPharmacol. Res.165105361(2021)