GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC33824 structure
    GC33824SDMA (Symmetric dimethylarginine)
    CAS: 30344-00-4
    纯度: >98.00% / >98.50%

    SDMA (Symmetric dimethylarginine)是精氨酸的甲基化形式，是一氧化氮合酶（NOS）的内源性抑制剂。

  • GC33825 structure
    GC33825Taurochenodeoxycholic acid (12-Deoxycholyltaurine)
    CAS: 516-35-8
    纯度: >98.00% / >99.00%

    Taurochenodeoxycholic acid (12-Deoxycholyltaurine)是一种牛磺酸结合胆汁酸。

  • GC33827 structure
    GC33827Uric acid
    CAS: 69-93-2
    纯度: >99.00% / >98.00%

    Uric Acid (2,6,8-Trioxypurine, 2,6,8-Trihydroxypurine, 2,6,8-Trioxopurine), a normal component of urine, is a product of the metabolic breakdown of purine nucleotides.

  • GC33829 structure
    GC33829Papain (≥800u/mg)
    CAS: 9001-73-4
    纯度: BA-803u/mg

    木瓜蛋白酶是一种具有广泛特异性的半胱氨酸蛋白酶，可切割碱性氨基酸、亮氨酸或甘氨酸的肽键。

  • GC33830 structure
    GC33830Uridine triphosphate (UTP)
    CAS: 63-39-8
    纯度: >98.00%

    三磷酸尿苷 (UTP) (UTP;Uridine 5'-triphosphate) 是一种核苷酸，可在正常和疾病状态下调节胰腺在内分泌和外分泌分泌、增殖、通道、转运体和细胞内信号传导方面的功能。

  • GC33838 structure
    GC33838Taurocholic Acid sodium hydrate (Sodium taurocholate hydrate)
    CAS: 345909-26-4
    纯度: >97.00%

    Taurocholic acid (Sodium taurocholate hydrate), a bile salt formed in the liver, is the product of conjugation of cholic acid with taurine that is involved in the emulsification of lipids. Its sodium salt is the chief ingredient of the bile of carnivorous animals.

  • GC33839 structure
    GC33839Cortisone (17-Hydroxy-11-dehydrocorticosterone)
    CAS: 53-06-5
    纯度: >97.00%

    A precursor and metabolite of cortisol

  • GC33846 structure
    GC33846Xanthine
    CAS: 69-89-6
    纯度: >98.00%

    Xanthine是一种天然存在的嘌呤碱基，广泛存在于茶叶和可可等植物中，也是生物体内嘌呤代谢途径的关键中间体。

  • GC33853 structure
    GC33853Talabostat (PT100)
    CAS: 149682-77-9

    Talabostat (PT100)是一种口服活性的二肽基肽酶IV DPP-IV IC50 < 4 nM的非选择性抑制剂;Ki = 0.18 nM，临床首个成纤维细胞活化蛋白FAP抑制剂IC50= 560 nM，抑制DPP 8/9的IC50= 4/11 nM;Ki = 1.5/0.76 nM，脯氨酸内肽酶QPP IC50= 310 nM, DPP2等DASH家族酶。

  • GC33855 structure
    GC33855DL-&alpha;-Tocopherol acetate (Vitamin E acetate)
    CAS: 52225-20-4
    纯度: >99.00%

    DL-α-Tocopherol acetate (DL-Alpha-tocopherol acetate , Vitamin E acetate), a vitamin E derivative, is used as a vitamin E supplement in poultry feeds.

  • GC33860 structure
    GC3386025-Hydroxycholesterol
    CAS: 2140-46-7
    纯度: >98.00% / >99.00%

    25-羟基胆固醇是胆固醇代谢生成的一种侧链氧甾醇，由巨噬细胞响应 Toll 样受体(TLR)激活分泌。

  • GC33881 structure
    GC33881Ro 31-9790 (GI4747)
    CAS: 145337-55-9

    Ro 31-9790 (GI4747) 是一种合成金属蛋白酶 (MMP) 抑制剂。

  • GC33885 structure
    GC33885UbcH5c-IN-1
    CAS: 2123480-72-6

    UbcH5c-IN-1(compound6d)是一种有效的、选择性的小分子泛素结合酶UbcH5c抑制剂，其与E2UbcH5c-IN-1活性位点Cys85共价结合的Kd值为283nM，是开发新型类风湿性关节炎药物的先导化合物。

  • GC33889 structure
    GC33889N-Acetyl-Ser-Asp-Lys-Pro
    CAS: 127103-11-1

    N-Acetyl-Ser-Asp-Lys-Pro是骨髓分泌的一种内源性四肽，是angiotensin-converting enzyme (ACE)的N末端位点的特异性底物。

  • GC33892 structure
    GC33892Cathepsin Inhibitor 2
    CAS: 1017931-53-1

    CathepsinInhibitor2是一种有效的CathepsinS抑制剂，Ki值<20nM。详细信息请参考专利文献WO2009123623A1中的段落0229。

  • GC33901 structure
    GC33901Pentanoic acid
    CAS: 109-52-4
    纯度: >99.00%

    Pentanoicacid是一种短链脂肪酸，是细菌代谢产物，与过敏性皮肤病有关系。Pentanoicacid能够激活ROCK信号通路。

  • GC33905 structure
    GC33905CMI-392
    CAS: 205654-37-1

    CMI-392是一种双重5-lipoxygenese抑制剂和血小板活化因子(PAF)受体拮抗剂，IC50值分别为100和10nM。

  • GC33907 structure
    GC33907LP117
    CAS: 1056468-55-3

    LP117是一种新型且有效的5-脂氧合酶(5-LO)产品合成抑制剂，其IC50值为1.1μM。

  • GC33930 structure
    GC33930Desaminotyrosine (3-(4-Hydroxyphenyl)propionic acid)
    CAS: 501-97-3
    纯度: >99.50%

    Phloretic acid (Desaminotyrosine, Hydro-p-coumaric acid, Phloretate, 3-(4-Hydroxyphenyl)propanoic acid) is a naturally occurring phenolic compound which can be produced by the hydrogenation of p-coumaric acid or synthesized from phloretin, a by-product of apple tree leaves.

  • GC33968 structure
    GC33968DPC-681 (DPH-153893)
    CAS: 284661-68-3
    纯度: >99.50%

    DPC-681 (DPH-153893) 是一种有效的选择性 HIV 蛋白酶抑制剂，对野生型 HIV-1 的 IC90 为 4 至 40 nM。

  • GC33976 structure
    GC339764',7-Dimethoxyisoflavone (Dimethoxydaidzein)
    CAS: 1157-39-7
    纯度: >95.00%

    4',7-Dimethoxyisoflavone, isolated from the leaves of Albizzia lebbeck, shows antifungal activity in vitro.

  • GC33991 structure
    GC33991Hydroxyphenyllactic acid
    CAS: 306-23-0
    纯度: >98.50% / >98.00%

    Hydroxyphenyllactic acid是一种酪氨酸代谢物。

  • GC33995 structure
    GC33995DL-3-Phenyllactic acid
    CAS: 828-01-3
    纯度: >99.50%

    DL-3-Phenyllacticacid是一种广谱抗菌化合物。

  • GC34011 structure
    GC34011FX-11 (LDHA Inhibitor FX11)
    CAS: 213971-34-7
    纯度: >98.00% / >97.00%

    FX-11（LDHA 抑制剂 FX11）被发现是一种有效的竞争性人 LDH-A 的 NADH 结合口袋抑制剂。