GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC33777 structure
    GC33777Creatine
    CAS: 57-00-1
    纯度: >98.00%

    Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue.Creatine can inhibits the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression.

  • GC33778 structure
    GC33778Hippuric acid (2-Benzamidoacetic acid)
    CAS: 495-69-2
    纯度: >99.00%

    Hippuric acid (2-Benzamidoacetic acid) 是一种口服活性代谢物。

  • GC33779 structure
    GC33779Cysteamine (β-Mercaptoethylamine)
    CAS: 60-23-1
    纯度: >95.00%

    2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.

  • GC33789 structure
    GC337891,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (1,2-DSPE)
    CAS: 1069-79-0
    纯度: >95.00% / >98.00%

    1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (1,2-DSPE)是一种磷脂酰乙醇胺（PE）脂质，可用于制备脂质体。

  • GC33797 structure
    GC33797(3-Carboxypropyl)trimethylammonium chloride
    CAS: 6249-56-5
    纯度: >98.00%

    (3-Carboxypropyl)trimethylammonium chloride (γ-Butyrobetaine, γBB hydrochloride) is an intermediary metabolite by gut microbes from dietary L-carnitine in mice.

  • GC33798 structure
    GC3379821-Hydroxypregnenolone
    CAS: 1164-98-3
    纯度: >98.00%

    21-Hydroxypregnenolone是皮质酮合成的重要中间体。

  • GC33799 structure
    GC33799Ursocholic acid
    CAS: 2955-27-3
    纯度: >98.00%

    Ursocholic acid是胆酸的7β-羟基差向异构体，具有高亲水性。

  • GC33800 structure
    GC3380010Z-Nonadecenoic acid
    CAS: 73033-09-7
    纯度: >99.00% / >98.00%

    10Z-Nonadecenoic acid 是一种具有抗肿瘤活性的长链脂肪酸。也可以抑制 p53 活性

  • GC33801 structure
    GC338011,5-Anhydrosorbitol
    CAS: 154-58-5
    纯度: >97.00%

    1,5-anhydro-D-glucitol 是 D-glucitol 的脱水糖。它具有作为人体代谢物的作用，在功能上与D-葡萄糖醇有关，是评价短期血糖控制情况的指标

  • GC33802 structure
    GC33802N-Acetyl-L-tyrosine
    CAS: 537-55-3
    纯度: >99.00%

    An active metabolite of, and precursor to, L-tyrosine

  • GC33803 structure
    GC33803Pi-Methylimidazoleacetic acid
    CAS: 4200-48-0

    Pi-Methylimidazoleaceticacid是一种潜在的神经毒素。

  • GC33804 structure
    GC33804Glycogen
    CAS: 9005-79-2
    纯度: >99.00%

    Glycogen (糖原)是一种多糖，在动物和细菌中作为重要的能量储存分子。

  • GC33805 structure
    GC33805Adipic acid
    CAS: 124-04-9
    纯度: >98.00%

    Adipic acid (Hexanedioic acid) is an important dicarboxylic acid used for the manufacture of nylon and polyurethane plastics.

  • GC33806 structure
    GC33806Tricosanoic acid
    CAS: 2433-96-7
    纯度: >99.50% / >98.00%

    A saturated fatty acid

  • GC33807 structure
    GC33807Alloepipregnanolone
    CAS: 516-55-2
    纯度: >98.00%

    An Analytical Reference Standard

  • GC33808 structure
    GC33808Diacylglycerol acyltransferase inhibitor-1
    CAS: 1610800-25-3

    Diacylglycerolacyltransferaseinhibitor-1是一个二酰基甘油酰基转移酶(DGAT1)抑制剂。

  • GC33810 structure
    GC338102-Methoxyestrone
    CAS: 362-08-3
    纯度: >98.00%

    An active metabolite of estrone

  • GC33811 structure
    GC33811Pimelic acid (1,5-Pentanedicarboxylic acid)
    CAS: 111-16-0
    纯度: >98.00%

    Pimelic acid (Heptanedioic acid, 1,5-Pentanedicarboxylic acid, 1,7-Heptanedioic acid) originating from fatty acid synthesis pathway is a bona fide precursor of biotin in B. subtilis.

  • GC33813 structure
    GC33813Xanthine oxidase-IN-1
    CAS: 1071970-13-2

    Xanthine oxidase-IN-1 是一种黄嘌呤氧化酶抑制剂，提取自专利 WO2008126898A1，第 68 页，化合物实施例 3，IC50 为 6.5 nM。

  • GC33814 structure
    GC33814Glutaric acid
    CAS: 110-94-1
    纯度: >98.00%

    Glutaric acid (GA) is an attractive C5 dicarboxylic acid with wide applications in the biochemical industry.

  • GC33815 structure
    GC338154-Hydroxyphenylacetic acid
    CAS: 156-38-7
    纯度: >99.00%

    A phenolic acid with anti-inflammatory and anti-steatotic activities

  • GC33817 structure
    GC338173,5-Dihydroxybenzoic acid
    CAS: 99-10-5
    纯度: >98.00% / >99.50%

    3,5-Dihydroxybenzoicacid是啤酒，坚果，花生和豆类等食物摄入的潜在生物标记。

  • GC33818 structure
    GC3381818-Hydroxycorticosterone
    CAS: 561-65-9

    18-Hydroxycorticosterone是皮质类固醇和皮质酮的衍生物，可能会引起严重的电解质失衡。

  • GC33819 structure
    GC33819Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid)
    CAS: 135-16-0
    纯度: >96.00% / >94.50% / >99.50%

    Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid)是维生素B9（叶酸或蝶酰-L-谷氨酸）的衍生物，在甲基四氢叶酸介导的吲哚胺甲基化过程中形成，并对甲基四氢叶酸依赖性甲基转移酶具有抑制作用，Ki值为0.1mM。