1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (1,2-DSPE) is a phosphoethanolamine (PE) lipid that can be used in the synthesis of liposomes [1]. Since amphiphilic nature, 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine can interact hydrophobically through polyenic segments of Amphotericin B (AmB), which concomitantly prevents the aggregation[2]. Modification of the natural killer (NK) cell surface using 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine imparts great stability and prolonged maintenance and accelerates the cell joining to form spheroids [3]. 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine is widely used as a phospholipid probe for membrane insertion to develop bifunctional microfluidic platforms for efficient capture of extracellular vesicles (EVs)[4].
References:
[1] Juszkiewicz K, Sikorski A F, Czogalla A. Building blocks to design liposomal delivery systems[J]. International journal of molecular sciences, 2020, 21(24): 9559.
[2] Arias E R, Angarita-Villamizar V, Baena Y, et al. Phospholipid-conjugated peg-b-pcl copolymers as precursors of micellar vehicles for amphotericin b[J]. Polymers, 2021, 13(11): 1747.
[3] Park J, Kim S, Jangid A K, et al. Networked cluster formation via trigonal lipid modules for augmented ex vivo NK cell priming[J]. International Journal of Molecular Sciences, 2024, 25(3): 1556.
[4] Hou G, Dong Y, Zhang M, et al. DSPE-Ti-Chip: A Dual-Functionalized Microfluidic Device for High-Efficiency Isolation of Extracellular Vesicle from Microvolume Biofluids[J]. Analytical Chemistry, 2026.
1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (1,2-DSPE)是一种磷脂酰乙醇胺（PE）脂质，可用于制备脂质体[1]。由于具有两亲性，1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine可通过两性霉素B的多烯片段发生疏水相互作用，同时防止聚集[2]。使用1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine修饰自然杀伤（NK）细胞表面，可赋予细胞良好的稳定性和持久维持能力，并加速细胞连接形成球体[3]。1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine被广泛用作膜插入的磷脂探针，以开发用于高效捕获细胞外囊泡的双功能微流控平台[4]。