Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC33648Taurocholic acid (N-Choloyltaurine)CAS: 81-24-3纯度: >99.00%
A quantitative analytical standard guaranteed to meet MaxSpec ? identity, purity, stability, and concentration specifications
- GC336533-Methoxybenzoic acid (3-Anisic acid)CAS: 586-38-9
3-Methoxybenzoic acid (m-Anisic acid, 3-Methoxybenzoate, 3-Anisic acid, m-Methylsalicylic acid) is a food additive that acts as a flavouring ingredient.
- GC336564-Hydroxy-3-methylbenzoic acidCAS: 499-76-3纯度: >98.00%
4-Hydroxy-3-methylbenzoic acid is a normal organic acid identified in urine specimens from a healthy population.
- GC33659Indolelactic acidCAS: 1821-52-9纯度: >99.50% / >98.00%
Indolelactic acid（Indole-3-lactic acid）是一种由色氨酸衍生的微生物代谢物，主要由肠道菌群产生。它作为信号分子参与调节宿主免疫反应和维持肠道稳态，具有抗炎特性，并在代谢通路和肠-脑轴通讯中发挥重要作用。
- GC33672Lurasidone Metabolite 14283 hydrochlorideCAS: 186204-32-0纯度: >99.00%
LurasidoneMetabolite14283hydrochloride是Lurasidone的主要的活性代谢物。
- GC33687Glycoursodeoxycholic acid (Ursodeoxycholylglycine)CAS: 64480-66-6纯度: >98.00%
A glycine-conjugated form of ursodeoxycholic acid
- GC337033,4,5-Trimethoxycinnamic acidCAS: 90-50-6 ; 20329-98-0纯度: >99.00%
3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.
- GC337383-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride)CAS: 1477-68-5纯度: >98.00%
A natural metabolite of dopamine
- GC337393-Methoxytyramine (3-O-methyl Dopamine)CAS: 554-52-9纯度: >98.00%
3-Methoxytyramine (3-O-methyl Dopamine) 是一种众所周知的 3-羟基酪胺/多巴胺的细胞外代谢物，是一种神经调节剂。
- GC337422-Hydroxyphenylacetic acidCAS: 614-75-5
2-Hydroxyphenylacetic acid (2-Hydroxybenzeneacetate, ortho-Hydroxyphenylacetic acid) is a substrate of the enzyme oxidoreductases in the pathway styrene degradation.
- GC33762Deoxycholic acid (Cholanoic Acid)CAS: 83-44-3纯度: >98.00%
Deoxycholic acid (Cholanoic Acid)是一种胆汁酸，肠道代谢副产物，可以激活G 蛋白偶联胆汁酸受体TGR5。
- GC33768Deoxycholic acid sodium salt (Sodium deoxycholate)CAS: 302-95-4纯度: >99.00%
Deoxycholic acid sodium salt (Sodium deoxycholate)是一种胆汁酸，是肠道代谢的副产物，可激活 G 蛋白偶联胆汁酸受体 TGR5。
- GC33769Gemigliptin (LC15-0444)CAS: 911637-19-9
Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC33648 | Taurocholic acid (N-Choloyltaurine) | 81-24-3 | >99.00% | |
A quantitative analytical standard guaranteed to meet MaxSpec ? identity, purity, stability, and concentration specifications | ||||
| GC33649 | 3,4-Dihydroxybenzeneacetic acid | 102-32-9 | >99.50% | |
A dopamine metabolite | ||||
| GC33650 | 5,6-Dihydrouracil | 504-07-4 | >98.00% | |
A catabolite of uracil | ||||
| GC33651 | Imidazoleacetic acid | 645-65-8 | - | |
Imidazoleaceticacid是刺激咪唑受体(imidazolereceptors)的内源性配体。 | ||||
| GC33653 | 3-Methoxybenzoic acid (3-Anisic acid) | 586-38-9 | - | |
3-Methoxybenzoic acid (m-Anisic acid, 3-Methoxybenzoate, 3-Anisic acid, m-Methylsalicylic acid) is a food additive that acts as a flavouring ingredient. | ||||
| GC33656 | 4-Hydroxy-3-methylbenzoic acid | 499-76-3 | >98.00% | |
4-Hydroxy-3-methylbenzoic acid is a normal organic acid identified in urine specimens from a healthy population. | ||||
| GC33659 | Indolelactic acid | 1821-52-9 | >99.50% / >98.00% | |
Indolelactic acid（Indole-3-lactic acid）是一种由色氨酸衍生的微生物代谢物，主要由肠道菌群产生。它作为信号分子参与调节宿主免疫反应和维持肠道稳态，具有抗炎特性，并在代谢通路和肠-脑轴通讯中发挥重要作用。 | ||||
| GC33660 | Dulcite (Dulcitol) | 608-66-2 | >99.00% | |
A reduced form of galactose | ||||
| GC33661 | Pseudouridine | 1445-07-4 | >99.50% / >97.00% | |
The C-5 glycoside isomer of uridine | ||||
| GC33663 | Teprenone (Geranylgeranylacetone) | 6809-52-5 | >99.50% | |
An inducer of Hsp expression | ||||
| GC33672 | Lurasidone Metabolite 14283 hydrochloride | 186204-32-0 | >99.00% | |
LurasidoneMetabolite14283hydrochloride是Lurasidone的主要的活性代谢物。 | ||||
| GC33687 | Glycoursodeoxycholic acid (Ursodeoxycholylglycine) | 64480-66-6 | >98.00% | |
A glycine-conjugated form of ursodeoxycholic acid | ||||
| GC33698 | 5-Hydroxyindole-3-acetic acid | 54-16-0 | >98.00% / >99.00% | |
A metabolite of serotonin | ||||
| GC33703 | 3,4,5-Trimethoxycinnamic acid | 90-50-6 ; 20329-98-0 | >99.00% | |
3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex. | ||||
| GC33704 | 6-Hydroxymelatonin | 2208-41-5 | >98.00% | |
An active metabolite of melatonin | ||||
| GC33738 | 3-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride) | 1477-68-5 | >98.00% | |
A natural metabolite of dopamine | ||||
| GC33739 | 3-Methoxytyramine (3-O-methyl Dopamine) | 554-52-9 | >98.00% | |
3-Methoxytyramine (3-O-methyl Dopamine) 是一种众所周知的 3-羟基酪胺/多巴胺的细胞外代谢物，是一种神经调节剂。 | ||||
| GC33742 | 2-Hydroxyphenylacetic acid | 614-75-5 | - | |
2-Hydroxyphenylacetic acid (2-Hydroxybenzeneacetate, ortho-Hydroxyphenylacetic acid) is a substrate of the enzyme oxidoreductases in the pathway styrene degradation. | ||||
| GC33746 | Dehydroascorbic acid | 490-83-5 | - | |
An oxidized form of ascorbic acid | ||||
| GC33748 | Ethylmalonic acid | 601-75-2 | >98.00% | |
Ethylmalonicacid是一种非致癌性的潜在有毒物质，与神经性厌食和甲氧基脱羧酶缺乏症有关。 | ||||
| GC33762 | Deoxycholic acid (Cholanoic Acid) | 83-44-3 | >98.00% | |
Deoxycholic acid (Cholanoic Acid)是一种胆汁酸，肠道代谢副产物，可以激活G 蛋白偶联胆汁酸受体TGR5。 | ||||
| GC33768 | Deoxycholic acid sodium salt (Sodium deoxycholate) | 302-95-4 | >99.00% | |
Deoxycholic acid sodium salt (Sodium deoxycholate)是一种胆汁酸，是肠道代谢的副产物，可激活 G 蛋白偶联胆汁酸受体 TGR5。 | ||||
| GC33769 | Gemigliptin (LC15-0444) | 911637-19-9 | - | |
Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α. | ||||
| GC33773 | Elaidic acid | 112-79-8 | >98.00% | |
A trans fatty acid | ||||