Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC42548 5-hydroxy Saxagliptin (hydrochloride) A major active metabolite of saxagliptin
GC42546 5-hydroxy Diclofenac
5-羟基双氯芬酸
An active metabolite of diclofenac
GC42484 5,6-dihydroxy Indole
5,6-二羟基吲哚
An intermediate in melanogenesis
GC42479 5(S)-HETrE A monohydroxy fatty acid synthesized by 5-LO from mead acid
GC42415 4-hydroxy Valsartan
4-羟基缬沙坦
A major metabolite of valsartan
GC42410 4-hydroxy Nonenal
4-羟基壬烯醛,4-HNE
4-羟基壬烯醛（4-hydroxy Nonenal，4-HNE）是一种脂质过氧化（LPO）产物，是一种α，β不饱和羟基烯醛，由ω-6多不饱和脂肪酸氧化形成，它是一种无色油。
GC42409 4-hydroxy Nebivolol (hydrochloride) A major metabolite of nebivolol
GC42407 4-hydroxy Diclofenac
4′-羟基双氯芬酸
A CYP2C9 metabolite of the NSAID diclofenac
GC42405 4-hydroxy Atorvastatin (calcium salt)
4-羟基阿托伐他汀（钙盐）
A metabolite of atorvastatin
GC42402 4-hydroxy (S)-Duloxetine β-D-Glucuronide (sodium salt)
LY550408
An inactive metabolite of (S)-duloxetine
GC42401 4-hydroperoxy Cyclophosphamide
培磷酰胺,4-OOH-CY
4-hydroperoxy Cyclophosphamide（4-羟基过氧化环磷酰胺），环磷酰胺的活性代谢产物，能够交联DNA并独立于caspase受体激活诱导T细胞凋亡，通过产生活性氧（ROS）激活线粒体死亡途径。
GC42370 4-desmethoxy Omeprazole
埃索美拉唑杂质B
A potential impurity found in commercial omeprazole and esomeprazole magnesium preparations
GC42351 4-carboxy TEMPO
4-羧基-2,2,6,6-四甲基氮杂环己烷-1-氧基自由基
A spin label
GC42307 3-O-methyl-L-DOPA (hydrate)
3-O-甲基-L-多巴一水合物
A metabolite of L-DOPA
GC42275 3-hydroxy Desloratidine
3-羟基去氯雷他定盐酸盐
A major metabolite of desloratadine
GC42274 3-hydroxy Darifenacin
UK 148993
A metabolite of darifenacin
GC42201 3,3'-Diiodo-L-thyronine
3,3'-二碘甲腺原氨酸,3,3'-T2
A metabolite of thyroid hormone
GC42198 3-(4-Chlorophenyl)-4-hydroxybutyric Acid (sodium salt)
γ-Hydroxybaclofen
An inactive metabolite of baclofen
GC42193 2-Thenoyltrifluoroacetone
2-噻吩甲酰三氟丙酮,HTTA; TTA; TTFA
An inhibitor of respiration
GC42189 2-oxo Clopidogrel
甲基(2-氯苯基)(2-氧代-2,6,7,7ALPHA-四氢噻吩并[3,2-C]吡啶-5(4H)-基)乙酸酯
An intermediary metabolite of clopidogrel
GC42150 2'-Deoxycytidine 5'-diphosphate (sodium salt hydrate)
2'-脱氧胞苷-5'-二磷酸三钠盐,dCDP trisodium
A nucleotide diphosphate
GC42082 20-carboxy Leukotriene B4
20-羧基白三烯B4
A LTB₄ metabolite
GC42042 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine, 15(S)-HpETE-SAPE, 15(S)-hydroperoxyeicostetraenoic acid-SAPE

An oxidized phospholipid
GC42041 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC
15(S)-HpETE-SAPC, 15(S)-Hydroperoxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Phosphatidylcholine

An oxidized phospholipid
GC42040 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE
15(S)-HETE-SAPE, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine

An oxidized phospholipid
GC42039 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC
15(S)-HETE-SAPC, 15(S)-Hydroxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylcholine
An oxidized phospholipid
GC42000 TRIA-662 (1-Methylnicotinamide chloride)
3-氨基甲酰-1-甲基氯化吡啶,1-Methylnicotinamide chloride; N-methylnicotinamide chloride
TRIA-662 (1-Methylnicotinamide chloride)是烟酰胺经烟酰胺N-甲基转移酶（NNMT）催化生成的主要代谢产物。
GC41999 1-Methylhistamine (hydrochloride)
1-甲基组胺二对甲苯磺酸盐
1-Methylhistamine (hydrochloride)是一种由组胺经组胺-N-甲基转移酶（HNMT）催化产生的主要代谢产物，用于评估体内组胺的代谢水平。
GC41980 18-carboxy dinor Leukotriene B4
18carboxy dinor LTB4
β-oxidation metabolite of LTB₄
GC41955 17-DMAG
阿螺旋霉素; 17-DMAG; NSC 707545
Water-soluble inhibitor of Hsp90
GC41952 17(R)-Resolvin D4
4(S),5(R),17(R)-trihydroxy-DHA, 17(R)-RvD4
An aspirin-triggered epimer of RvD4
GC41951 17(R)-Resolvin D1
Aspirin-triggered Resolvin D1
An aspirin-triggered epimer of RvD1
GC41940 15-OxoEDE
15KEDE
A PUFA produced by oxidation of 15-HEDE
GC41938 15-Lipoxygenase Inhibitor 1
15LO Inhibitor 1
An inhibitor of 15-LO
GC41937 15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide
15-KETO-比马前列素
A potential metabolite of Bimatoprost
GC41927 15(S)-HETrE A 5-LO inhibitor
GC41926 15(S)-HETE-biotin
15(S)-Hydroxyeicosatetraenoic Acid-biotin
Used to detect 15(S)-HETE binding proteins and/or receptors
GC41925 15(S)-HETE Ethanolamide
15(S)-HAEA, 15(S)-Hydroxyeicosatetraenoic Acid Ethanolamide
A CB₁ receptor ligand and FAAH inhibitor
GC41911 13-epi-12-oxo Phytodienoic Acid
13-EPI-12-氧代植物二烯酸
A lipoxygenase metabolite of α-linolenic acid
GC41900 13(S)-HpOTrE(γ) Produced by the action of soybean LO-1 on γ-linolenic acid
GC41899 13(S)-HpOTrE
A product of soybean LO-2 metabolism of α-linolenic acid
GC41898 13(S)-HOTrE(γ) A 15-LO product derived from GLA
GC41897 13(S)-HOTrE A 15-LO product derived from GLA
GC41896 13(S)-HODE-biotin A biotinylated PUFA
GC41882 12(S)-HETrE An inhibitor of platelet activation
GC41837 1,3,7-Trimethyluric Acid
1,3,7-三甲基尿酸,8-oxo Caffeine, NSC 11259
A metabolite of caffeine
GC41825 1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt)
1,2-Dipalmitoyl-sn-glycero-3-phosphatidic Acid, 1,2-Dipalmyitoyl-sn-glycero-3-phophate, 1,2-DPPA, 16:0/16:0-PA
1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt)（16:0/16:0-PA）是一种磷脂，含有插入到sn-1和sn-2位置的长链（16:0）棕榈酸，能够用于制备脂质体、胶束和人工膜。
GC41804 1,2-Dimyristoyl-sn-glycero-3-PE
1,2-十四酰基磷脂酰乙醇胺
A phospholipid
GC41778 1,2,3-Tripalmitoyl-rac-glycerol
(三)棕榈酸甘油酯
A triacylglycerol
GC41776 Triolein (1,2,3-Trioleoyl-rac-glycerol)
三油酸甘油酯
Triolein (1,2,3-Trioleoyl-rac-glycerol)是一种甘油三酯，被用于研究脂质代谢相关过程。Triolein可作为模型底物来探究脂肪在体内的消化、吸收以及转运等情况。