3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.
TMCA decreased the locomotor activity in mice, prolonged total sleep time, and reduced sleep latency induced by pentobarbital. TMCA also increased the total sleep time and non-rapid eye movement (NREM) sleep. It alters sleep architecture through GABAAergic systyems[1]. TMCA exhibits anti-stress actions by the suppression of norepinephrine (NE) content in locus coeruleus (LC) induced by corticotrophin-releasing hormone (CRH)[2].
[1] Lee CI, et al. Arch Pharm Res. 2013, 36(10):1244-51. [2] Kawashima K, et al. Biol Pharm Bull. 2004, 27(8):1317-9.
















