Hydroxyphenyllactic acid is a tyrosine metabolite [1]. Hydroxyphenyllactic acid inhibits the production of reactive oxygen species (ROS) in mitochondria and neutrophils, thereby exerting a natural antioxidant effect [2]. Hydroxyphenyllactic acid is primarily used to treat fungi [3-4].
In AML-12 cells, Hydroxyphenyllactic acid (0.1μg/mL, 0.5μg/mL; 24h) treatment protects against ethanol-induced damage [5].
In C57BL/6 mice, Hydroxyphenyllactic acid (42mg; sc; 30d) has embryogenic activity [6].
References:
[1]. Mu W, Yu S, Zhu L, et al. Production of 3-phenyllactic acid and 4-hydroxyphenyllactic acid by Pediococcus acidilactici DSM 20284 fermentation[J]. European Food Research and Technology, 2012, 235(3): 581-585.
[2]. Beloborodova N, Bairamov I, Olenin A, et al. Effect of phenolic acids of microbial origin on production of reactive oxygen species in mitochondria and neutrophils[J]. Journal of biomedical science, 2012, 19(1): 89.
[3]. Lunavath R, Mohammad S H, Bhukya K K, et al. Antimycotic effect of 3-phenyllactic acid produced by probiotic bacterial isolates against Covid-19 associated mucormycosis causing fungi[J]. PLoS One, 2023, 18(3): e0279118.
[4]. Li C, Deng Y, Wang J, et al. Effects of p-hydroxyphenylacetic acid and p-hydroxybenzoic acid on soil bacterial and fungal communities[J]. Sustainability, 2023, 15(12): 9285.
[5]. Zhang C, Chen Y, Huang S, et al. 3, 4-hydroxyphenyl lactic acid from Lactiplantibacillus plantarum prevents alcoholic liver injury in mice[J]. bioRxiv, 2025: 2025.03. 12.642873.
[6]. Rauschenbach M O, Zharova E I, Sergeeva T I, et al. Blastomogenic activity of p-hydroxyphenyllactic acid in mice[J]. Cancer research, 1975, 35(3): 577-585.
Hydroxyphenyllactic acid是一种酪氨酸代谢物 [1]。Hydroxyphenyllactic acid能抑制线粒体和中性粒细胞中活性氧（ROS）的产生，从而发挥天然抗氧化作用 [2]。羟苯乳酸主要用于治疗真菌 [3-4]。
在AML-12细胞中，Hydroxyphenyllactic acid（0.1μg/mL，0.5μg/mL；24h）治疗可防止乙醇引起的损伤 [5]。
在C57BL/6小鼠中，Hydroxyphenyllactic acid （42mg；sc：30d）具有胚胎致胚活性 [6]。