Cortisone is a glucocorticoid receptor-inert precursor and metabolite of the glucocorticoid cortisol .1,2 Cortisone is converted to glucocorticoid receptor-active cortisol by 11β-hydroxysteroid dehydrogenase (11β-HSD1) and is regenerated by metabolism of cortisol by 11β-HSD2 in vivo.
1.Dammann, C., Stapelfeld, C., and Maser, E.Expression and activity of the cortisol-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 is tissue and species-specificChem. Biol. Interact.30357-61(2019) 2.Viglietti, A.I.P., Giambartolomei, G.H., and Delpino, M.V.Endocrine modulation of Brucella abortus-infected osteocytes function and osteoclastogenesis via modulation of RANKL/OPGMicrobes Infect.21(7)287-295(2019)