20-HETE

20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature.¹ In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction.² 20-HETE is excreted mainly as the glucuronide conjugate. The concentration of free 20-HETE (20-40 pg/ml in human urine) is about 10-fold lower than the corresponding concentration of the 20-glucuronide.³ 20-HETE can be further metabolized by cyclooxygenase to 20-hydroxy PGG₂ and 20-hydroxy PGH₂.⁴

20-HETE是一种被认为在肾脏和脑血管中发挥自分泌作用的细胞色素P450（CYP450）代谢产物。在大鼠脑微血管中，20-HETE是一种血管收缩剂，介导压力诱导的自主调节血管收缩。20-HETE主要以葡萄糖醛酸结合物的形式排泄。游离20-HETE的浓度（人尿液中20-40 pg/ml）约为20-葡萄糖醛酸酯的浓度的10倍。20-HETE可以被环氧合酶进一步代谢为20-羟基PGG₂和20-羟基PGH₂。

1.McGiff, J.C., and Quilley, J.20-HETE and the kidney: Resolution of old problems and new beginningsAm. J. Physiol.277(3)R607-R623(1999) 2.Gebremedhin, D., Lange, A.R., Lowry, T.F., et al.Production of 20-HETE and its role in autoregulation of cerebral blood flowCirc. Res.87(1)60-65(2000) 3.Prakash, C., Zhang, J.Y., Falck, J.R., et al.20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urineBiochem. Biophys. Res. Commun.185(2)728-733(1992) 4.Schwartzman, M.L., Falck, J.R., Yadagiri, P., et al.Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase. Formation and identification of novel endothelium-dependent vasoconstrictor metabolitesJ. Biol. Chem.264(20)11658-11662(1989)