Heptamethine cyanine dye-1 (ADS 815EI) is a near-infrared cyanine dye characterized by good water solubility, low toxicity，with an absorption/emission wavelength of approximately 780/800nm[1][2]. Heptamethine cyanine dye-1 (ADS 815EI) has a long triplet-state lifetime, a high singlet oxygen quantum yield, and low dark toxicity, has shown the targeting ability for mitochondria in intracellular subcellular localization and exhibits good tumor targeting and bioavailability by coupling some compounds，such as TPP[3][4]. These properties make Heptamethine cyanine dye-1 (ADS 815EI) suitable for tissue imaging, photodynamic therapy, and drug delivery systems[5-7].
References:
[1] Cheng, G., Fan, J., Sun, W., Cao, J., Hu, C., & Peng, X. (2014). A near-infrared fluorescent probe for selective detection of HClO based on Se-sensitized aggregation of heptamethine cyanine dye. Chemical communications (Cambridge, England), 50(8), 1018–1020.
[2] Pan, G. Y., Jia, H. R., Zhu, Y. X., Wang, R. H., Wu, F. G., & Chen, Z. (2017). Dual Channel Activatable Cyanine Dye for Mitochondrial Imaging and Mitochondria-Targeted Cancer Theranostics. ACS biomaterials science & engineering, 3(12), 3596–3606.
[3] Ning, J., Huang, B., Wei, Z., Li, W., Zheng, H., Ma, L., Xing, Z., Niu, H., & Huang, W. (2017). Mitochondria targeting and near-infrared fluorescence imaging of a novel heptamethine cyanine anticancer agent. Molecular medicine reports, 15(6), 3761–3766.
[4] Cooper, E., Choi, P. J., Denny, W. A., Jose, J., Dragunow, M., & Park, T. I. (2021). The Use of Heptamethine Cyanine Dyes as Drug-Conjugate Systems in the Treatment of Primary and Metastatic Brain Tumors. Frontiers in oncology, 11, 654921.
[5] Yang, X., Shi, C., Tong, R., Qian, W., Zhau, H. E., Wang, R., Zhu, G., Cheng, J., Yang, V. W., Cheng, T., Henary, M., Strekowski, L., & Chung, L. W. (2010). Near IR heptamethine cyanine dye-mediated cancer imaging. Clinical cancer research : an official journal of the American Association for Cancer Research, 16(10), 2833–2844.
[6] Jiao, L., , Song, F., , Cui, J., , & Peng, X., (2018). A near-infrared heptamethine aminocyanine dye with a long-lived excited triplet state for photodynamic therapy. Chemical communications (Cambridge, England), 54(66), 9198–9201.
[7] Choi, P. J., Park, T. I. H., Cooper, E., Dragunow, M., Denny, W. A., & Jose, J. (2020). Heptamethine Cyanine Dye Mediated Drug Delivery: Hype or Hope. Bioconjugate chemistry, 31(7), 1724–1739.
Heptamethine cyanine dye-1 (ADS 815EI) 是一种具有近红外吸收特性的花青染料，具有良好的水溶性和低毒性，吸收/发射波长约为 780/800 nm[1][2]。Heptamethine cyanine dye-1 (ADS 815EI) 具有较长的三重态寿命、较高的单线态氧量子产率和较低的暗毒性，并通过偶联一些化合物如TPP,靶向细胞内的线粒体, 具有良好的肿瘤靶向性和生物利用度[3][4]。这些特性使得 Heptamethine cyanine dye-1 (ADS 815EI) 适用于组织成像、光动力治疗和药物传递系统[5-7]。