GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC91157 structure
    GC91157C18
    CAS: 2922824-09-5
    纯度: >98.00%

    一种共价的GPX4抑制剂

  • GC91278 structure
    GC91278Doxepin N-oxide (hydrate)
    纯度: >95.00%

    多西平的代谢产物。

  • GC91296 structure
    GC91296p-Carboxyphenyl Sulfate
    CAS: 3233-38-3
    纯度: >95.00%

    一种硫酸化的酚酸。

  • GC91375 structure
    GC91375Promethazine Sulfoxide
    CAS: 7640-51-9
    纯度: >95.00%

    盐酸普罗米嗪是组胺H1受体拮抗剂普罗米嗪的代谢产物。它由细胞色素P450（CYP）同工酶CYP2D6将普罗米嗪转化而成。

  • GC91380 structure
    GC91380N6F11
    CAS: 851398-76-0
    纯度: >99.50%

    N6F11 is a novel, selective and potent inducer of iron death with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.

  • GC91397 structure
    GC91397N-desmethyl Levofloxacin (hydrochloride)
    纯度: >98.00%

    N-去甲基左氧氟沙星是氟喹诺酮类抗生素左氧氟沙星的活性代谢产物。它对金黄色葡萄球菌、表皮葡萄球菌、枯草杆菌、大肠杆菌、铜绿假单胞菌和肺炎克雷伯杆菌具有活性（最小抑制浓度分别为4，1，1，0.012，> 4和0.25μg/ml）。

  • GC91406 structure
    GC91406UK 122 (trifluoroacetate salt)
    CAS: 1186653-73-5
    纯度: >95.00%

    UK 122是一种尿激酶型纤溶酶原激活剂（uPA）抑制剂（IC50 = 0.2 uM）。它选择性地作用于uPA，而不影响组织型纤溶酶原激活剂（tPA）、胰蛋白酶、纤溶酶和凝血酶（所有的IC50均大于100uM）。

  • GC91418 structure
    GC91418(E)-KPT-330
    CAS: 1421923-86-5
    纯度: >95.00%

    (E)-KPT-330是selinexor的代谢产物，它是exportin 1 (XPO1/CRM1)抑制剂的一种。它由细胞色素P450（CYP）亚型CYP3A4从selinexor中形成。

  • GC91480 structure
    GC91480Exendin-4 (3-39) amide (trifluoroacetate salt)
    纯度: >90.00%

    Exendin-4 (3-39)酰胺是一种糖肽样肽1受体（GLP-1R）激动剂，也是exendin-4 (48-86)酰胺的活性代谢物。

  • GC91492 structure
    GC91492Propiverine N-oxide
    CAS: 111071-96-6
    纯度: >95.00%

    Propiverine N-oxide is an active metabolite of the muscarinic acetylcholine receptor antagonist propiverine .

  • GC91594 structure
    GC91594LYS-006 (hydrochloride)
    CAS: 2619563-79-8
    纯度: >98.00%

    LYS-006 is an inhibitor of leukotriene A4 (LTA4) hydrolase.

  • GC91595 structure
    GC91595PDIC-NC
    CAS: 2633013-75-7
    纯度: >95.00%

    PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent.

  • GC91598 structure
    GC91598GPX4 16
    CAS: 2644044-43-7
    纯度: >98.00%

    GPX4 16 is an inhibitor of glutathione peroxidase 4 (GPX4).

  • GC91613 structure
    GC91613FerroLOXIN-1
    CAS: 2773428-48-9
    纯度: >90.00%

    FerroLOXIN-1 is an inhibitor of the 15-lipoxygenase-2 (15-LO-2) and phosphatidylethanolamine-binding protein 1 (PEBP1) catalytic complex.

  • GC91623 structure
    GC91623Ferroptosis Inducer 24
    CAS: 28657-88-7
    纯度: >95.00%

    Ferroptosis inducer 24 is an inducer of ferroptosis.

  • GC91688 structure
    GC91688PDIC-NN
    CAS: 932740-48-2
    纯度: >95.00%

    PDIC-NN is an intermediate in the synthesis of PDIC-NS , an activator of stimulator of interferon genes (STING) with anticancer activity.

  • GC91782 structure
    GC91782DPP-9 Inhibitor 42
    纯度: >95.00%

    DPP-9 inhibitor 42 is an inhibitor of dipeptidyl peptidase 9 (DDP-9; IC50 = 0.0034 µM).

  • GC91800 structure
    GC91800CPPA-TPP
    纯度: >75.00%

    CPPA-TPP is a chain transfer agent conjugated to the mitochondria-targeting moiety triphenylphosphonium (TPP).

  • GC91820 structure
    GC91820PDIC-NS
    纯度: >95.00%

    PDIC-NS is an activator of stimulator of interferon genes (STING).

  • GC92031 structure
    GC92031GPX4 Inhibitor 17
    纯度: >98.00%

    GPX4 Inhibitor 17是一种含二茂铁的谷胱甘肽过氧化物酶4 （GPX4）抑制剂和铁下垂诱导剂。

  • GC92061 structure
    GC920611-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC
    CAS: 161923-56-4
    纯度: >95.00%

    1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC是分别在sn-1和sn-2位置含有棕榈酸和13S-HODE的氧化磷脂。

  • GN10040 structure
    GN10040Dehydrocorydaline
    CAS: 30045-16-0
    纯度: >99.00%

    Dehydrocorydaline是从延胡索中分离得到的一种季铵生物碱。

  • GN10055 structure
    GN10055Mulberroside A
    CAS: 102841-42-9
    纯度: >98.00%

    A phenol with diverse biological activities

  • GN10062 structure
    GN100625-HTP
    CAS: 56-69-9
    纯度: >99.50%

    5-HTP 是一种色氨酸代谢物，是一种直接的 5-羟色胺 (5-HT) 前体和 L-芳香族氨基酸脱羧酶底物。