Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GN10063ArctigeninCAS: 7770-78-7纯度: >99.50%
Arctigenin是一种天然木脂素化合物，已证实具有抗癌活性。Arctigenin具有强效的抗氧化、抗炎和抗病毒（甲型流感病毒）活性。
- GN10091SchaftosideCAS: 51938-32-0纯度: >99.50%
A flavonoid C-glycoside with diverse biological activities
- GN10184Oleanolic acidCAS: 508-02-1纯度: >98.00%
Oleanolic acid齐墩果酸是一种天然的五环三萜，长期以来一直被用作治疗肝炎的有效药物。齐墩果酸对多种癌症也有抗肿瘤作用。
- GN10211Salvianolic acid ACAS: 96574-01-5纯度: >99.50% / >98.00%
Salvianolic acid A是一种多靶点药理活性的多酚化合物，其通过靶向TGF-β受体I（TβRI）抑制TGF-β1信号通路的活性，还能下调MMP9蛋白的表达。它通常被用于心血管疾病和器官纤维化的研究。
- GN10227Sodium DemethylcantharidateCAS: 13114-29-9
Extracted from Mylabris phqlarata pallas;Store the product in sealed, cool and dry condition
- GN10285TheobromineCAS: 83-67-0纯度: >99.00%
A methylxanthine alkaloid with diverse biological activities
- GN10289TrigonellineCAS: 535-83-1纯度: >99.50%
Trigonelline是一种从 Trigonella foenum-graecum L 或 Leonurus artemisia 中分离出来的生物碱，是一种强效且特异性的Nrf2抑制剂。
- GN10342Chondroitin sulfate (from bovine)CAS: 9007-28-7纯度: >98.00% / >95.00%
Chondroitin sulfate (from bovine)是从牛软骨中提取的天然多糖。
- GN10347Nicotinamide (Vitamin B3)CAS: 98-92-0纯度: >99.50%
Nicotinamide (Vitamin B3)是维生素B3的酰胺衍生物，可以抑制SIRT1（IC 50 ：50-180μM）和SIRT2（IC 50 ：2μM）的活性。Nicotinamide还可增加细胞中NAD + 、ATP、ROS水平。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GN10063 | Arctigenin | 7770-78-7 | >99.50% | |
Arctigenin是一种天然木脂素化合物，已证实具有抗癌活性。Arctigenin具有强效的抗氧化、抗炎和抗病毒（甲型流感病毒）活性。 | ||||
| GN10072 | Daidzin | 552-66-9 | >99.50% | |
Natural isoflavone | ||||
| GN10073 | Arbutin | 497-76-7 | >99.50% | |
A glycosylated hydroquinone with diverse biological activities | ||||
| GN10091 | Schaftoside | 51938-32-0 | >99.50% | |
A flavonoid C-glycoside with diverse biological activities | ||||
| GN10146 | Butane diacid | 110-15-6 | >98.00% | |
丁烷二酸是一种有效且具有口服活性的抗焦虑剂。 | ||||
| GN10158 | Baicalein | 491-67-8 | >98.50% / >98.00% | |
Baicalein（黄芩素；5，6，7-三羟基黄酮）是具有多种生物活性的黄酮类化合物，是黄嘌呤氧化酶抑制剂，IC 50 值为3.12μM。 | ||||
| GN10184 | Oleanolic acid | 508-02-1 | >98.00% | |
Oleanolic acid齐墩果酸是一种天然的五环三萜，长期以来一直被用作治疗肝炎的有效药物。齐墩果酸对多种癌症也有抗肿瘤作用。 | ||||
| GN10190 | Cinnamic acid | 140-10-3 | >99.50% | |
肉桂酸是一种天然抗菌剂，对鱼类病原体 A 的最低抑菌浓度 (MIC) 为 250 μg/mL。 | ||||
| GN10211 | Salvianolic acid A | 96574-01-5 | >99.50% / >98.00% | |
Salvianolic acid A是一种多靶点药理活性的多酚化合物，其通过靶向TGF-β受体I（TβRI）抑制TGF-β1信号通路的活性，还能下调MMP9蛋白的表达。它通常被用于心血管疾病和器官纤维化的研究。 | ||||
| GN10227 | Sodium Demethylcantharidate | 13114-29-9 | - | |
Extracted from Mylabris phqlarata pallas;Store the product in sealed, cool and dry condition | ||||
| GN10267 | Loureirin B | 119425-90-0 | >99.00% | |
A flavonoid with diverse biological activities | ||||
| GN10269 | Wedelolactone | 524-12-9 | >99.50% | |
A natural NF-κB inhibitor | ||||
| GN10285 | Theobromine | 83-67-0 | >99.00% | |
A methylxanthine alkaloid with diverse biological activities | ||||
| GN10289 | Trigonelline | 535-83-1 | >99.50% | |
Trigonelline是一种从 Trigonella foenum-graecum L 或 Leonurus artemisia 中分离出来的生物碱，是一种强效且特异性的Nrf2抑制剂。 | ||||
| GN10290 | Norcantharidin | 29745-04-8 | - | |
An inhibitor of PP1 and PP2A | ||||
| GN10304 | Taxifolin | 480-18-2 | >99.50% / >98.00% | |
Taxifolin是一种酪氨酸酶抑制剂，并具有显著的胶原酶抑制活性，其IC 50 值为193.3μM。 | ||||
| GN10306 | Folic acid | 59-30-3 | >99.50% / >98.00% | |
An essential B vitamin | ||||
| GN10342 | Chondroitin sulfate (from bovine) | 9007-28-7 | >98.00% / >95.00% | |
Chondroitin sulfate (from bovine)是从牛软骨中提取的天然多糖。 | ||||
| GN10347 | Nicotinamide (Vitamin B3) | 98-92-0 | >99.50% | |
Nicotinamide (Vitamin B3)是维生素B3的酰胺衍生物，可以抑制SIRT1（IC 50 ：50-180μM）和SIRT2（IC 50 ：2μM）的活性。Nicotinamide还可增加细胞中NAD + 、ATP、ROS水平。 | ||||
| GN10349 | Ergosterol | 57-87-4 | - | |
A fungal sterol | ||||
| GN10359 | Stigmasterol | 83-48-7 | >98.00% | |
Stigmasterol豆甾醇是一种天然的甾醇。Stigmasterol具有显著的抗关节炎和抗炎作用。 | ||||
| GN10360 | Morroniside | 25406-64-8 | >98.00% | |
A mixture of iridoid glucosides | ||||
| GN10382 | Xylitol | 87-99-0 | >98.00% | |
木糖醇是一种化学物质，归类为多元醇或糖醇。 | ||||
| GN10423 | Lipoic acid | 62-46-4 | >99.50% | |
硫辛酸 ((R)-(+)-α-硫辛酸) 是一种抗氧化剂，是线粒体酶复合物的重要辅助因子。 | ||||