DPP-9 Inhibitor 42

DPP-9 inhibitor 42 is an inhibitor of dipeptidyl peptidase 9 (DDP-9; IC₅₀ = 0.0034 µM).^[1] It is selective for DDP-9 over DPP-8, DPP-4, DPP-2, fibroblast activation protein (FAP), and prolyl endopeptidase (IC₅₀s = 0.6, >10, >5, 10, and >10 µM, respectively). DPP-9 inhibitor 42 (10 µM) induces lactate dehydrogenase (LDH) release from THP-1 acute monocytic and HL-60 promyeloblast leukemia cells.

References:
[1].Benramdane, S., De Loose, J., Filippi, N., et al.Highly selective inhibitors of dipeptidyl peptidase 9 (DPP9) derived from the clinically used DPP4-inhibitor vildagliptinJ. Med. Chem.66(18)12717-12738(2023).