Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC52049Myricetin 3-galactosideCAS: 15648-86-9纯度: >98.00%
A flavonoid with diverse biological activities
- GC52094L-Carnitine-d9 (chloride)CAS: 2687961-04-0纯度: >99.00%
An internal standard for the quantification of L-carnitine
- GC52132N-desmethyl Diltiazem (hydrochloride)CAS: 130606-60-9纯度: >90.00%
An active metabolite of diltiazem
- GC52214Nicotinamide riboside-d4 (triflate)纯度: >95.00%
An internal standard for the quantification of nicotinamide riboside
- GC522275-(3',4'-Dihydroxyphenyl)-γ-ValerolactoneCAS: 21618-92-8纯度: >95.00%
An active metabolite of various polyphenols
- GC52231Heptadecanoyl-L-carnitine-d3 (chloride)纯度: >95.00%
An internal standard for the quantification of heptadecanoyl-L-carnitine
- GC52236Nonadecanoyl-L-carnitine-d3 (chloride)纯度: >99.00%
An internal standard for the quantification of nonadecanoyl-L-carnitine
- GC523243-(3-Hydroxyphenyl)propionic Acid sulfateCAS: 86321-32-6纯度: >95.00%
A metabolite of certain phenols and glycosides
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC52049 | Myricetin 3-galactoside | 15648-86-9 | >98.00% | |
A flavonoid with diverse biological activities | ||||
| GC52052 | Dofetilide N-oxide | 144449-71-8 | >98.00% | |
A metabolite of dofetilide | ||||
| GC52054 | Ranitidine S-oxide | 73851-70-4 | >90.00% | |
A metabolite of ranitidine | ||||
| GC52059 | AMOZ | 43056-63-9 | >98.00% | |
A metabolite of furaltadone | ||||
| GC52060 | Trimipramine N-oxide | 14171-70-1 | >90.00% | |
An active metabolite of trimipramine | ||||
| GC52074 | Loratadine N-oxide | 165739-62-8 | >95.00% | |
A metabolite of loratadine | ||||
| GC52076 | Temozolomide Acid | 113942-30-6 | >98.00% | |
An active metabolite of temozolomide | ||||
| GC52094 | L-Carnitine-d9 (chloride) | 2687961-04-0 | >99.00% | |
An internal standard for the quantification of L-carnitine | ||||
| GC52105 | Montelukast | 158966-92-8 | >99.00% | |
A CysLT 1 receptor antagonist | ||||
| GC52132 | N-desmethyl Diltiazem (hydrochloride) | 130606-60-9 | >90.00% | |
An active metabolite of diltiazem | ||||
| GC52168 | Aripiprazole N,N-dioxide | 573691-13-1 | >90.00% | |
A metabolite of aripiprazole | ||||
| GC52173 | N-desmethyl-Doxylamine (succinate) | 2731375-61-2 | >90.00% | |
A metabolite of doxylamine | ||||
| GC52177 | Perphenazine Sulfoxide | 10078-25-8 | >98.00% | |
An active metabolite of perphenazine | ||||
| GC52214 | Nicotinamide riboside-d4 (triflate) | - | >95.00% | |
An internal standard for the quantification of nicotinamide riboside | ||||
| GC52219 | Heptadecanoyl-L-carnitine (chloride) | 173686-69-6 | >95.00% | |
A long-chain acylcarnitine | ||||
| GC52223 | Nonadecanoyl-L-carnitine (chloride) | - | >95.00% | |
A long-chain acylcarnitine | ||||
| GC52227 | 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone | 21618-92-8 | >95.00% | |
An active metabolite of various polyphenols | ||||
| GC52231 | Heptadecanoyl-L-carnitine-d3 (chloride) | - | >95.00% | |
An internal standard for the quantification of heptadecanoyl-L-carnitine | ||||
| GC52236 | Nonadecanoyl-L-carnitine-d3 (chloride) | - | >99.00% | |
An internal standard for the quantification of nonadecanoyl-L-carnitine | ||||
| GC52256 | CAY10794 | 1231243-91-6 | >98.00% | |
An inhibitor of DGAT-1 | ||||
| GC52290 | (R)-HTS-3 | 2771208-83-2 | >98.00% | |
An inhibitor of LPCAT3 | ||||
| GC52306 | Pentadecanoyl-L-carnitine (chloride) | 173686-57-2 | >98.00% | |
A CB receptor agonist | ||||
| GC52324 | 3-(3-Hydroxyphenyl)propionic Acid sulfate | 86321-32-6 | >95.00% | |
A metabolite of certain phenols and glycosides | ||||
| GC52355 | BimS BH3 (51-76) (human) (trifluoroacetate salt) | - | >95.00% | |
A Bim-derived peptide | ||||