GlpBio

BimS BH3 (51-76) (human) (trifluoroacetate salt)

目录号: GC52355纯度: >95.00%同义词: DMRPEIWIAQELRRIGDEFNAYYARR-OH, Bims (51-76)
A Bim-derived peptide
BimS BH3 (51-76) (human) (trifluoroacetate salt)
规格价格库存数量操作
5 mg¥1,008.00现货
1
10 mg¥1,918.00现货
1
25 mg¥4,522.00现货
1
50 mg¥8,008.00现货
1
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文献被引

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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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产品描述 Description

BimS BH3 (51-76) is a peptide that corresponds to amino acids 51-76 of the short splice variant of the pro-apoptotic protein Bim (BimS), which contains the Bcl-2 homology 3 (BH3) motif.1 It binds to myeloid cell leukemia-1 (Mcl-1), Bcl-xL, Bcl-2, and Bcl-W (IC50s = 18, 10, 7, and 18 nM, respectively). BimS BH3 (51-76) induces cytochrome c release from mitochondria derived from bcl-x-/- mouse embryonic fibroblasts (MEFs).

1.Lee, E.F., Fedorova, A., Zobel, K., et al.Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteinsJ. Biol. Chem.284(45)31315-31326(2009)

产品文档 Product Documents

Purity:>95.00%Appearance:A solid

化学性质Chemical Properties

同义词
DMRPEIWIAQELRRIGDEFNAYYARR-OH, Bims (51-76)
SMILES
OC(C(F)(F)F)=O.O=C(O)C[C@H](N[H])C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N[C@@H](CCC(O)=O)C(N[C@@](C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@@](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@](C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](CC5=CC=C(O)C=C5)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)C)=O)=O)=O)C)=O)=O)CC6=CC=CC=C6)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)CC(C)C)=O)=O)=O)C)=O)([H])[C@@H](C)CC)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O
分子式
C145H222N44O41S ? XCF3COOH
分子量
3269.7 g/mol
溶解性
DMF: 3 mg/ml,DMSO: 2 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): insol
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol