Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC50251PF 3084014 hydrobromideCAS: 1962925-29-6纯度: >98.00% / >95.00%
PF 3084014 hydrobromide是一种高效且高选择性的γ-分泌酶抑制剂，属于氮杂环类化合物，其IC₅₀为1.2nM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC50129 | TC-E 5008 | 50405-58-8 | - | |
Selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor; phenotypically lethal | ||||
| GC50134 | Bengamide B | 104947-69-5 | - | |
Potent inhibitor of NF-κB activation | ||||
| GC50151 | NHI 2 | 1269802-97-2 | - | |
An inhibitor of LDHA | ||||
| GC50153 | BIX | 101714-41-4 | >99.50% | |
An inducer of GRP78 | ||||
| GC50189 | TAPI 0 | 163958-73-4 | - | |
TAPI 0 是一种 TACE（TNF-α 转化酶；ADAM17）抑制剂，IC50 为 100 nM。 | ||||
| GC50225 | ONO 6818 | 208848-19-5 | - | |
ONO 6818 (ONO-6818) 是一种有效且具有口服活性的中性粒细胞弹性蛋白酶抑制剂，Ki 为 12.2 nM。 | ||||
| GC50251 | PF 3084014 hydrobromide | 1962925-29-6 | >98.00% / >95.00% | |
PF 3084014 hydrobromide是一种高效且高选择性的γ-分泌酶抑制剂，属于氮杂环类化合物，其IC₅₀为1.2nM。 | ||||
| GC50283 | HM 50316 | 1310361-52-4 | - | |
High affinity FABP4 inhibitor | ||||
| GC50353 | T 26c disodium salt | 869298-22-6 | >98.00% | |
A selective inhibitor of MMP-13 | ||||
| GC50368 | INF 4E | 88039-46-7 | - | |
INF 4E 是一种有效的 NLRP3 炎性体抑制剂。 | ||||
| GC50373 | Retrobradykinin | 5991-13-9 | - | |
逆缓激肽具有与缓激肽相反的序列。 | ||||
| GC50447 | Pep 2-8 | 1541011-97-5 | >99.00% | |
Pep 2-8是一种由13个氨基酸组成的线性肽，可抑制PCSK9活性（K D =0.7μM），并抑制LDL受体及EGF(A)结构域与PCSK9的结合，IC 50 值分别为0.8μM和0.4μM。 | ||||
| GC50570 | ST 045849 | 442665-87-4 | >98.50% | |
ST 045849是一种O-GlcNAc转移酶(OGT)抑制剂，IC 50 值为53μM。 | ||||
| GC50613 | 673 A | 109437-62-9 | - | |
ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC) | ||||
| GC50650 | SBP1 | 2451986-45-9 | >95.00% | |
Human ACE2 receptor-derived 23-amino acid peptide | ||||
| GC50653 | SBP1-FITC | - | >95.00% | |
Fluorescently labelled peptide derived from human ACE2 (SBP1) | ||||
| GC52005 | Triazolomethylindole-3-acetic Acid | 177270-91-6 | >95.00% | |
A metabolite of rizatriptan | ||||
| GC52007 | N-hydroxylamine Dapsone | 32695-27-5 | >98.00% | |
An active metabolite of dapsone | ||||
| GC52019 | Norpropranolol (hydrochloride) | 62618-09-1 | >98.00% | |
An active metabolite of propranolol | ||||
| GC52024 | Aripiprazole N-oxide | 573691-09-5 | >90.00% | |
A metabolite of aripiprazole | ||||
| GC52029 | 2-Aminoflubendazole | 82050-13-3 | >95.00% | |
A metabolite of flubendazole | ||||
| GC52033 | S-Methyl-D-penicillamine | 29913-84-6 | >95.00% | |
A metabolite of D-penicillamine | ||||
| GC52035 | Esmolol Acid (hydrochloride) | 83356-60-9 | >98.00% | |
An active metabolite of esmolol | ||||
| GC52045 | N-desmethyl Azelastine | 47491-38-3 | >98.00% | |
An active metabolite of azelastine | ||||