Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC49806C18 Ganglioside GD3-d3 (ammonium salt)CAS: 2692624-24-9纯度: >99.00%
An internal standard for the quantification of ganglioside G D3
- GC49817Desethoxy Quetiapine (hydrochloride)CAS: 329218-14-6纯度: >95.00%
An active metabolite of quetiapine
- GC4982010,11-dihydro-10,11-dihydroxy CarbamazepineCAS: 35079-97-1纯度: >95.00%
A metabolite of carbamazepine and oxcarbazepine
- GC498232′-C-β-MethylguanosineCAS: 374750-30-8纯度: >95.00%
An active nucleoside metabolite of BMS-986094
- GC49843AposcopolamineCAS: 535-26-2纯度: >95.00%
A tropane alkaloid and an active metabolite of scopolamine
- GC49855Harmalol (hydrochloride hydrate)CAS: 6028-00-8纯度: >98.00%
A β-carboline alkaloid and an active metabolite of harmaline
- GC49858Desipramine-d4 (hydrochloride)CAS: 61361-34-0纯度: >98.50%
An internal standard for the quantification of desipramine
- GC49875(±)-N-desmethyl Venlafaxine (hydrochloride)CAS: 93413-90-2纯度: >95.00%
A minor active metabolite of venlafaxine
- GC4989415(S)-HETE-d8 ethyl ester纯度: >99.00%
An internal standard for the quantification of 15(S)-HETE ethyl ester
- GC50113Noradrenaline bitartrateCAS: 51-40-1纯度: >99.00%
Noradrenaline bitartrate是一种β1选择性肾上腺素受体激动剂，EC 50 值为5.37μM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC49778 | Etheroleic Acid | 169217-38-3 | >98.00% | |
A divinyl ether oxylipin | ||||
| GC49780 | Omeprazole N-oxide | 176219-04-8 | >98.00% | |
A metabolite of omeprazole | ||||
| GC49794 | N-desmethyl Trimipramine | 2293-21-2 | >95.00% | |
An active metabolite of trimipramine | ||||
| GC49806 | C18 Ganglioside GD3-d3 (ammonium salt) | 2692624-24-9 | >99.00% | |
An internal standard for the quantification of ganglioside G D3 | ||||
| GC49817 | Desethoxy Quetiapine (hydrochloride) | 329218-14-6 | >95.00% | |
An active metabolite of quetiapine | ||||
| GC49820 | 10,11-dihydro-10,11-dihydroxy Carbamazepine | 35079-97-1 | >95.00% | |
A metabolite of carbamazepine and oxcarbazepine | ||||
| GC49823 | 2′-C-β-Methylguanosine | 374750-30-8 | >95.00% | |
An active nucleoside metabolite of BMS-986094 | ||||
| GC49832 | Hydroxymetronidazole | 4812-40-2 | >95.00% | |
An active metabolite of metronidazole | ||||
| GC49842 | Digoxigenin Bisdigitoxoside | 5297-05-2 | >98.00% | |
A Na + /K + -ATPase inhibitor | ||||
| GC49843 | Aposcopolamine | 535-26-2 | >95.00% | |
A tropane alkaloid and an active metabolite of scopolamine | ||||
| GC49845 | Piribedil N-oxide | 53954-71-5 | >90.00% | |
A metabolite of piribedil | ||||
| GC49849 | 3-Aminosalicylic Acid | 570-23-0 | >98.00% | |
A salicylic acid derivative | ||||
| GC49851 | Norquetiapine | 5747-48-8 | >98.00% | |
An active metabolite of quetiapine | ||||
| GC49855 | Harmalol (hydrochloride hydrate) | 6028-00-8 | >98.00% | |
A β-carboline alkaloid and an active metabolite of harmaline | ||||
| GC49858 | Desipramine-d4 (hydrochloride) | 61361-34-0 | >98.50% | |
An internal standard for the quantification of desipramine | ||||
| GC49863 | Cytarabine 5′-monophosphate | 7075-11-8 | >95.00% | |
An active metabolite of cytarabine | ||||
| GC49866 | Desmethyl Carvedilol | 72956-44-6 | >90.00% | |
An active metabolite of carvedilol | ||||
| GC49869 | 3-Methoxytyrosine | 7636-26-2 | >95.00% | |
An active metabolite of L-DOPA | ||||
| GC49875 | (±)-N-desmethyl Venlafaxine (hydrochloride) | 93413-90-2 | >95.00% | |
A minor active metabolite of venlafaxine | ||||
| GC49894 | 15(S)-HETE-d8 ethyl ester | - | >99.00% | |
An internal standard for the quantification of 15(S)-HETE ethyl ester | ||||
| GC49901 | BAY-179 | 2764880-87-5 | >98.00% | |
A mitochondrial complex I inhibitor | ||||
| GC50060 | Cerestat | 137160-11-3 | - | |
An NMDA receptor antagonist | ||||
| GC50089 | PEAQX tetrasodium salt | - | >98.00% | |
Potent and GluN2A-selective NMDA antagonist | ||||
| GC50113 | Noradrenaline bitartrate | 51-40-1 | >99.00% | |
Noradrenaline bitartrate是一种β1选择性肾上腺素受体激动剂，EC 50 值为5.37μM。 | ||||