Desethoxy quetiapine is an active metabolite of the atypical antipsychotic quetiapine .1 It is formed from quetiapine primarily by the cytochrome P450 (CYP) isoform CYP3A5 and binds to dopamine D2 receptors (IC50 = 1,330 nM).2,1 Desethoxy quetiapine (20 and 40 mg/kg) reduces climbing induced by the dopamine receptor agonist apomorphine in mice. It also improves apomorphine-induced swimming deficits in mice.1
1.Warawa, E.J., Migler, B.M., Ohnmacht, C.J., et al.Behavioral approach to nondyskinetic dopamine antagonists: Identification of seroquelJ. Med. Chem.44(3)372-389(2001) 2.Bakken, G.V., Rudberg, I., Christensen, H., et al.Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome B5Drug Metab. Dispos.37(2)254-258(2009)