10,11-dihydro-10,11-dihydroxy Carbamazepine is a metabolite of the anticonvulsant carbamazepine and the antiepileptic prodrug oxcarbazepine .1 It is formed from carbamazepine via a carbamazepine 10,11-epoxide intermediate by epoxide hydrolase and from oxcarbazepine via a 10,11-dihydro-10-hydroxy carbamazepine intermediate.2,1 10,11-dihydro-10,11-dihydroxy Carbamazepine has been found in wastewater effluent.3
1.Franceschi, L., and Furlanut, M.A simple method to monitor plasma concentrations of oxcarbazepine, carbamazepine, their main metabolites and lamotrigine in epileptic patientsPharmacol. Res.51(4)297-302(2005) 2.Tybring, G., van Bahr, C., Bertilsson, L., et al.Metabolism of carbamazepine and its epoxide metabolite in human and rat liver in vitroDrug. Metab. Dispos.9(6)561-564(1981) 3.Miao, X.-S., Yang, J.-J., and Metcalfe, C.D.Carbamazepine and its metabolites in wastewater and in biosolids in a municipal wastewater treatment plantEnviron. Sci. Technol.39(19)7469-7475(2005)